Sweetener influences plasma concentration of flavonoids in humans after an acute intake of a new (poly)phenol-rich beverage

Agulló, Vicente; Domínguez‐Perles, Raúl; García‐Viguera, Cristina

doi:10.1016/j.numecd.2020.11.016

Cited by 14 publications

(13 citation statements)

References 23 publications

(36 reference statements)

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“…We cannot discard that these effects might be associated with pharmacodynamic mechanisms, but also with a pharmacokinetic influence since sucralose provided the greatest absorption value in humans for most of the maqui berry metabolites, followed by stevia and with a minor influence of sucrose after the ingestion of a new maqui-citrus-based beverage supplemented with these sweeteners. These results suggest that non-caloric sweeteners are better alternatives than a high caloric sweetener to avoid the augmented risk of several metabolic disorders [7,34] (Reference [35] is cited in the Supplementary Materials), but also as an alternative to painful effects as was observed in this preclinical study.…”

Section: Discussionsupporting

confidence: 56%

“…In order to contribute to responding to such demand, we studied a new previously own-developed maqui–citrus beverage [ 3 ], rich in bioavailable bioactive compounds, with anti-inflammatory and antioxidant activity [ 4 , 5 , 6 , 7 ], which we look to propose as a natural treatment to relieve pain.…”

Section: Introductionmentioning

confidence: 99%

“…Because of this, a combination of citrus with maqui berry might be the base of new bioactive beverages with potential activity to face different diseases, such as pain and neurological system disorders. This statement is based on previous studies [ 4 , 5 , 6 , 7 ], focused on the intake of a recently developed maqui–citrus beverage, with different added sweeteners, in which the bioaccessibility and bioavailability of the bioactive compounds, as well as their effects on glycemic response in overweight subjects, have been demonstrated. However, the activity against different diseases has not yet been described.…”

Section: Introductionmentioning

confidence: 99%

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Synergistic Interaction in the Analgesic-Like Effects of Maqui Berry and Citrus Is Antagonized by Sweeteners

et al. 2021

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Although physiologically pain has a protective function, in many diseases, it is one of the most prominent symptoms. Today, new trends are focused on finding more natural alternatives to conventional treatments to alleviate it. Thereby, the purpose of this investigation was to obtain preclinical data of the antinociceptive properties of a lyophilized obtained from a newly designed maqui–citrus beverage alone and added with different sweeteners. To achieve this objective, maqui berry and citrus pharmacological activity were studied separately, as well as the interaction of both ingredients. In addition, due to the controversy generated regarding the intake of sugars, related to different metabolic diseases, the influence of different sweeteners (stevia, sucralose, or sucrose) was studied to determine their possible influence on the bioactive compounds of this product. For the attainment of our goals, a pharmacological evaluation, using the 1% formalin test, a nociceptive pain model in mice, was performed by using a sub-efficacious dosage of Maqui (25 mg/kg, i.p.) alone and combined with citrus, and then compared with the effects obtained in the presence of the different sweeteners. As a result, the antinociceptive response of the maqui was synergized in the presence of citrus in the neurogenic and inflammatory phases of the formalin test. However, this response was partially or totally reduced in the presence of the sweeteners. Our study gives preclinical evidence that a combination of maqui and citrus might exert beneficial actions to relieve pain, whereas the presence of sweeteners could reduce or avoid it.

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Section: Discussionsupporting

confidence: 56%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Synergistic Interaction in the Analgesic-Like Effects of Maqui Berry and Citrus Is Antagonized by Sweeteners

et al. 2021

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“…Maqui-berry is a source of several anthocyanidin constituents, many of them derived from delphinidin compound (%83% of total anthocyanins À 13.71 mg/ g). Moreover, previous studies have demonstrated that these anthocyanins are bioavailable for humans (Agull o, Dom ınguez-Perles, et al 2021;Agull o, Dom ınguez-Perles, Moreno, et al 2020;Agull o, Villaño, et al 2020), and they could be detected intact in brain, among other tissues (Kalt et al 2008). It has also been reported that a stabilisation of delphinidin, in a formulation for system administration, reversed mechanical and thermal hyperalgesia, as well as local inflammation, in part, because of its capacity to scavenge superoxide anion radicals with and inhibitory concentration of 70 ± 5 mM (Sauer et al 2020).…”

Section: Discussionmentioning

confidence: 97%

“…and 250, 500 and 1000 mg/kg, p.o.). These doses were considered taking into account our preliminary acute studies in healthy volunteers (Agull o, Dom ınguez-Perles, et al 2021;Agull o, Villaño, et al 2020), where the anthocyanin bioavailability was analysed after the intake of 330 mL of a juice containing 3.3 g of A. chilensis (54.75 mg of anthocyanins) (Salar et al 2020). In accordance with Nair and Jacob (2016), when extrapolated to average weigh human of 70 kg b.w., this amount would be similar to 500 mg/kg, p.o.…”

Section: Antinociceptive Activity Experimental Designmentioning

confidence: 99%

Antinociceptive effects of maqui-berry (Aristotelia chilensis (Mol.) Stuntz)

Agulló

González-Trujano

Hernandez-Leon

et al. 2021

International Journal of Food Sciences and Nutrition

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Maqui-berry is characterised by presenting a high concentration of (poly)phenols, accounting anthocyanins (cyanidin and delphinidin) for over 85% of the total. These coloured flavonoids have demonstrated potential neurological activity, but the evidence of their antinociceptive properties is scarce. In order to cover this gap, different doses (suitable for human administration) of a maqui-berry powder (1.6% anthocyanin), using enteral and parenteral routes of administration, were compared at central and peripheral levels using a nociceptive pain model (formalin test) in mice. Gastric damage analysis as possible adverse effects of analgesic and antiinflammatory drugs was also explored. Dose-antinociceptive response was confirmed using both routes of administration and in both neurogenic and inflammatory phases of the formalin test, without gastric damage. In conclusion, these preliminary data provide evidence of pharmacological properties of maqui-berry to alleviate nociceptive pain.

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Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols

et al. 2022

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The health benefits associated with (poly)phenols need to be supported by robust and insightful information on their biological effects. The use of in vitro, ex vivo, and in vivo models is crucial to demonstrate functionalities in specific targets. In this regard, bioaccessibility, bioavailability, and tissue/organ distribution need to be fully understood and established. In addition, the structure–function relationships, concerning both descriptive and mechanistic information, between specific compounds and therapeutic objectives, need to be supported by results obtained from in vivo studies. Nevertheless, these studies are not always possible or have some limitations, particularly concerning the mechanistic information explaining the health benefits provided that should be covered with complementary experimental models. Based on these premises, this review aims to overview the contribution of the separate experimental approaches to gain insights into the bioaccessibility, bioavailability, and bioactivity of (poly)phenols. To achieve this objective, recent evidence available on the linkage of healthy/functional foods with the incidence of non‐communicable pathologies is presented. The different experimental approaches provide complementary information that allows advances to be applied to the knowledge gained on the functional properties and mechanistic facts responsible for the health attributions of polyphenols. © 2022 The Authors. Journal of The Science of Food and Agriculture published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.

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Sweetener influences plasma concentration of flavonoids in humans after an acute intake of a new (poly)phenol-rich beverage

Abstract: Please cite this article as: Agulló V, Domínguez-Perles R, García-Viguera C, Sweetener influences plasma concentration of flavonoids in humans after an acute intake of a new (poly)phenol-rich beverage, Nutrition, Metabolism and Cardiovascular Diseases,

Cited by 14 publications

References 23 publications

Synergistic Interaction in the Analgesic-Like Effects of Maqui Berry and Citrus Is Antagonized by Sweeteners

Synergistic Interaction in the Analgesic-Like Effects of Maqui Berry and Citrus Is Antagonized by Sweeteners

Antinociceptive effects of maqui-berry (Aristotelia chilensis (Mol.) Stuntz)

Contribution of the diverse experimental models to unravelling the biological scope of dietary (poly)phenols

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