Abstract:The aim of this study was to investigate the effectiveness of SGLT2 inhibitors with regard to metabolic parameters and patient safety under routine ambulatory conditions. Retrospective longitudinal study of 95 patients with type 2 diabetes (diabetes duration 13.3 y; HbA1c 8.9%; eGFR 80.1 mL/min) receiving SGLT-2-inhibitors. Metabolic control and adverse event profile were evaluated. The mean follow-up time was 1.2 ± 0.8 years. The following changes were observed: HbA1c −1.0% ± 1.9 (p < 0.001), eGFR −7.0 mL/… Show more
“…( 19 , 20 ) The rates of DKA in major trials were 0.1–0.5% over 4–8 years ( 19 – 21 ), in concert with a large Australian observational study showing an incidence of 0.1% over 26 months ( 22 ). In comparison to non-SGLT2i antihyperglycemic medications, there was no statistically significant increase of risk in SGLT2i use for type 2 diabetic patients ( 23 ). The US Food and Drug Administration (FDA) and European Medicines Association (EMA) respectively issued drug safety reports on DKA risk in SGLT2i patients with DKA-like symptoms at health services ( 3 ).…”
Section: Diabetic Ketoacidosis (Dka) and Euglycemic Dkamentioning
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a relatively novel class of drug for treating type 2 diabetes mellitus (T2DM) that inhibits glucose reabsorption in the renal proximal tubule to promote glycosuria and reduce blood glucose levels. SGLT2i has been clinically indicated for treating T2DM, with numerous recent publications focussing on both primary and secondary prevention of cardiovascular and renal events in Type 2 diabetic patients. The most recent clinical trials showed that SGLT2i have moderately significant beneficial effects on atherosclerotic major adverse cardiovascular events (MACE) in patients with histories of atherosclerotic cardiovascular disease. In this review and analysis, SGLT2i have however demonstrated clinically significant benefits in reducing hospitalisation for heart failure and worsening of chronic kidney disease (CKD) irrespective of pre-existing atherosclerotic cardiovascular disease or previous heart failure history. A meta-analysis suggests that all SGLT2 inhibitors demonstrated the therapeutic benefit on all-cause and cardiovascular mortality, as shown in EMPAREG OUTCOME study with a significant decrease in myocardial infarction, without increased stroke risk. All the above clinical trial recruited type 2 diabetic patients. This article aims to postulate and review the possible primary prevention role of SGLT2i in healthy individuals by reviewing the current literature and provide a prospective overview. The emphasis will include primary prevention of Type 2 Diabetes, Heart Failure, CKD, Hypertension, Obesity and Dyslipidaemia in healthy individuals, whom are defined as healthy, low or intermediate risks patients.
“…( 19 , 20 ) The rates of DKA in major trials were 0.1–0.5% over 4–8 years ( 19 – 21 ), in concert with a large Australian observational study showing an incidence of 0.1% over 26 months ( 22 ). In comparison to non-SGLT2i antihyperglycemic medications, there was no statistically significant increase of risk in SGLT2i use for type 2 diabetic patients ( 23 ). The US Food and Drug Administration (FDA) and European Medicines Association (EMA) respectively issued drug safety reports on DKA risk in SGLT2i patients with DKA-like symptoms at health services ( 3 ).…”
Section: Diabetic Ketoacidosis (Dka) and Euglycemic Dkamentioning
Sodium-glucose cotransporter-2 inhibitors (SGLT2i) are a relatively novel class of drug for treating type 2 diabetes mellitus (T2DM) that inhibits glucose reabsorption in the renal proximal tubule to promote glycosuria and reduce blood glucose levels. SGLT2i has been clinically indicated for treating T2DM, with numerous recent publications focussing on both primary and secondary prevention of cardiovascular and renal events in Type 2 diabetic patients. The most recent clinical trials showed that SGLT2i have moderately significant beneficial effects on atherosclerotic major adverse cardiovascular events (MACE) in patients with histories of atherosclerotic cardiovascular disease. In this review and analysis, SGLT2i have however demonstrated clinically significant benefits in reducing hospitalisation for heart failure and worsening of chronic kidney disease (CKD) irrespective of pre-existing atherosclerotic cardiovascular disease or previous heart failure history. A meta-analysis suggests that all SGLT2 inhibitors demonstrated the therapeutic benefit on all-cause and cardiovascular mortality, as shown in EMPAREG OUTCOME study with a significant decrease in myocardial infarction, without increased stroke risk. All the above clinical trial recruited type 2 diabetic patients. This article aims to postulate and review the possible primary prevention role of SGLT2i in healthy individuals by reviewing the current literature and provide a prospective overview. The emphasis will include primary prevention of Type 2 Diabetes, Heart Failure, CKD, Hypertension, Obesity and Dyslipidaemia in healthy individuals, whom are defined as healthy, low or intermediate risks patients.
“…In einer Untersuchung von Routinedaten trat bei 21,1 % der Studienteilnehmer eine Genitalinfektion bzw. eine Harnwegsinfektion auf, die zum Therapieabbruch führte [38]. Aus diesem Grund ist eine adäquate Aufklärung der Patienten über die entsprechenden Hygienemaßnahmen zwingend notwendig.…”
ZUSAMMENFASSUNGDie chronische Nierenkrankheit (CKD: „chronic kidney disease“) stellt eine der häufigsten Folgekomplikationen bei Menschen mit Diabetes mellitus dar und erhöht exzessiv die Morbidität und Mortalität. Daher ist die Vorbeugung einer Nephropathie von klinischer Bedeutung. Im Mittelpunkt der Therapie stand in den letzten Jahren die antihypertensive und nephroprotektive Therapie mit ACE-Hemmern (ACE: „angiotensin converting enzyme“) oder ATII1-Rezeptor-Antagonisten (ATII1: Angiotensin-II-Rezeptor Subtyp-1; Blockade des Renin-Angiotensin-Systems (RAS)) in der Kombination mit einer antiglykämischen und lipidsenkenden Therapie im Rahmen eines multimodalen Therapiekonzepts. Inzwischen zeigen Antidiabetika signifikante und intrinsische nephroprotektive Effekte, die über die reine Glukosesenkung hinausgehen. Als besonders potent haben sich dabei Hemmer des Natrium-Glukose-Kotransporters 2 (SGLT-2: „sodium glucose linked transporter 2“) und GLP1-Rezeptor-Agonisten (GLP1: „glucagon-like peptide 1“) herausgestellt. GLP1-Rezeptor-Agonisten reduzieren vor allem die Albuminurie bei Menschen mit Typ-2-Diabetes. SGLT-2-Hemmer verlangsamen auch den Abfall der glomerulären Filtrationsrate (GFR) über die Zeit und konnten diesen nephroprotektiven Effekt sowohl bei Menschen mit Diabetes als auch bei jenen ohne Diabetes zeigen. Entsprechend wird in Leitlinien für Menschen mit Diabetes mellitus Typ 2 und CKD oder erhöhtem kardialen Risiko empfohlen, neben Metformin und der RAS-Blockade, die Therapie mit SGLT-2-Hemmern und – sofern zur Glykämiesenkung notwendig – additiv GLP1-Rezeptor-Agonisten anzuwenden.
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