Comparative efficacy and safety of traditional Chinese patent medicine for NAFLD in childhood or adolescence

Abstract

Background: Nonalcoholic fatty liver disease is a common reason for chronic liver disease in children and adults. The increasing incidence of the disease has become one of the most critical public health problems in the 21st century, closely related to genetic and environmental factors. So far, apart from changing lifestyle and diet, modern medicine still lacks effective treatment measures. Chinese patent medicine has the advantages of apparent curative effect, overall regulation and fewer side effects. However, there is a lack of research on the simultaneous comparison of various Chinese patent medicines. Therefore, we used a reticular meta-analysis to indirectly compare the efficacy and safety of different oral Chinese patent medicines through standard reference. Method: We will conduct a comprehensive and systematic search of Chinese and English databases from the beginning to December 2020. All randomized controlled trials (RCTs) of oral Chinese patent medicine for NAFLD in children will be searched. The 2 researchers then independently filter the retrieved literature, extract the data according to the data extraction table and assess the risk of bias. We will perform a pair of meta-analyses and a Bayesian network meta-analysis. STATA and Win BUGS software will be used for data analysis. Results: This study will thoroughly compare and analyze the differences in the efficacy of all kinds of TCPM in NAFLD treatment in childhood or adolescence. Conclusion: This study will provide reference and evidence support for clinical drug selection optimization. Ethics and dissemination: This study does not require ethical approval. INPLASY registration number: 2020120068.

Integrated strategy of RNA-sequencing and network pharmacology for exploring the protective mechanism of Shen-Shi-Jiang-Zhuo formula in rat with non-alcoholic fatty liver disease

“… 2020 ; Sun et al. 2021 ). In TCM, the treatment of NAFLD mainly focussed on the holism of hepatoprotection, which manifests as various forms and features in mechanism, including lipid metabolism modulation and anti-fibrosis, etc.…”

Dietary and Nutritional Interventions in Nonalcoholic Fatty Liver Disease in Pediatrics

“…Subsequently, a study by Li et al estimated that the prevalence of NAFLD in the pediatric age group is 7.4% and that in children with obesity, the prevalence reaches 52.5%, regardless of the diagnostic method, projecting a prevalence of 30.7% for the year 2040 [3]. Added to these studies, the prevalence of NAFLD in populations with obesity varies geographically with a higher prevalence being reported in Central America and the Middle East, with 42.5% in children aged 8-11 years determined by alanine aminotransferase (ALT) levels in blood serum [4,5].…”