Conservative management of primary malignant melanoma of the bladder: a case report

Abstract

Background Primary malignant melanoma (PMM) of the bladder represents a very rare clinic-pathologic entity. Given the rarity of the disease, the best treatment option is not well recognized. Case presentation We describe a case of neoplasm of the bladder in a 74 years-old Caucasian man presenting with massive hematuria. Based on clinical, instrumental and histological findings a diagnosis of PMM was made. The patient underwent trans urethral resection of bladder tumor plus intravesical Bacillus Calmette–Guérin. Conclusions To make a correct diagnosis, clinical history, endoscopic evaluation, histopathological examination and immunohistochemistry, are necessary. Multidisciplinary evaluation is required to discriminate primary from metastatic malignant melanoma.

Demographics, Clinical Characteristics and Survival Outcomes of Primary Urinary Tract Malignant Melanoma Patients: A Population-Based Analysis

“…In consequence, contemporary data are clearly needed. Moreover, other previous case series addressing primary urinary tract malignant melanomas were single-institution or multi-institutional reports that relied on very limited sample sizes [ 5 , 14 , 15 , 17 , 19 , 20 , 22 , 23 , 24 , 25 , 26 , 27 , 28 ]. For example, the largest case series addressing primary urinary tract malignant melanoma regardless of tumor location was reported by Acikalin et al, who relied on eight cases [ 22 ].…”

“…The remainder of the available studies consisted of either smaller scale or even more historical single-institutional or multi-institutional series that addressed primary urinary tract malignant melanoma cases in their entirety, regardless of tumor location [ 22 ], or focused on single tumor location [ 11 , 14 , 15 , 17 , 19 , 23 , 24 , 25 , 26 , 27 , 28 , 29 ]. For example, Acikalin et al focused on primary malignant melanoma of the entire urinary tract [ 22 ].…”

“…Conversely, Oliva et al only focused on primary malignant melanoma of the urethra [ 23 ]. Similarly, for the exceedingly rare nature of primary malignant melanoma within the bladder, only reports with, at best, two cases exist [ 5 , 14 , 24 , 25 , 26 , 27 , 28 ].…”

Urological Melanoma: A Comprehensive Review of a Rare Subclass of Mucosal Melanoma with Emphasis on Differential Diagnosis and Therapeutic Approaches

“…During the subsequent 2-year follow-up, the patient was disease-free and showed no signs of major toxicity. Recently, in 2021, Rapisarda et al [55] described the clinical history of a 74-year-old man with primary melanoma of the bladder. He was treated with TURBT plus intravesical chemotherapy with Bacillus Calmette-Guérin (BCG), that offers a further treatment option for this neoplasia, but only in selected cases.…”