Sting pathway – A futuristic therapeutic target for acute pancreatitis?

Sundar, Vaishnavi; Dutta, Anupam; Ramasamy, S.; Manickam, Venkatraman; Tamizhselvi, Ramasamy

doi:10.1016/j.gene.2021.145469

Cited by 7 publications

(1 citation statement)

References 70 publications

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“…Acute pancreatitis (AP) is characterized by an excessive and destructive inflammatory reaction, triggered by dysregulated activation of pancreatic zymogens and subsequent self-digestion of the pancreas, and usually associated with tissue injury, organ dysfunction, and local or systemic complications. 1,2 Disease severity, risk stratification, and clinical prognosis of AP depend on the presence and progression of organ dysfunction and local or systemic complications. [3][4][5] While most AP cases fall within the manageable range of mild to moderately severe, severe AP (SAP) is characterized by single or multiple organs involvement or even dysfunction, need for intensive care unit (ICU)-level care and organ support, and high mortality, thus posing a significant risk to human health.…”

Section: Introductionmentioning

confidence: 99%

Predictive and Prognostic Potentials of Lymphocyte-C-Reactive Protein Ratio Upon Hospitalization in Adult Patients with Acute Pancreatitis

Xu,

Gao,

Yue

et al. 2024

JIR

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Purpose In this study, our objective was to investigate the potential utility of lymphocyte-C-reactive protein ratio (LCR) as a predictor of disease progression and a screening tool for intensive care unit (ICU) admission in adult patients with acute pancreatitis (AP). Methods We included a total of 217 adult patients with AP who were admitted to the First Affiliated Hospital of Harbin Medical University between July 2019 and June 2022. These patients were categorized into three groups: mild AP (MAP), moderately severe AP (MSAP), and severe AP (SAP), based on the presence and duration of organ dysfunction. Various demographic and clinical data were collected and compared among different disease severity groups. Results Height, diabetes, lymphocyte count (LYMPH), lymphocyte percentage (LYM%), platelet count (PLT), D-Dimer, albumin (ALB), blood urea nitrogen (BUN), serum creatinine (SCr), glucose (GLU), calcium ion (Ca 2+ ), C-reactive protein (CRP), procalcitonin (PCT), hospitalization duration, ICU admission, need for BP, LCR, sequential organ failure assessment (SOFA) score, bedside index for severity in AP (BISAP) score, and modified Marshall score showed significant differences across different disease severity groups upon hospitalization. Notably, there were significant differences in LCR between the MAP group and the MSAP and SAP combined group, and the MAP and MSAP combined group and the SAP group, and adult AP patients with ICU admission and those without ICU admission upon hospitalization. Conclusion In summary, LCR upon hospitalization can be utilized as a simple and reliable predictor of disease progression and a screening tool for ICU admission in adult patients with AP.

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