Synthetic Routes Towards the Synthesis of Geminal α‐Difunctionalized Ketones

Abstract

The importance of gem‐difunctionalized ketones is represented by their broad applications across chemical boundaries over recent years. The interesting reactivities that this class of compounds possess have made them ideal building blocks to access high‐value organic molecules. Furthermore, the gem‐difunctionalized ketone moiety has featured in numerous bioactive molecules. For these reasons, a plethora of routes to access such significant molecules have been developed by research groups worldwide – this account looks at delineating the synthesis of gem‐difunctionalized ketones from carbonyl substrates, diazo compounds, sulfur ylides and alkynyl reactants.

An Improved Protocol for the Synthesis of Carbonyl Sulfoxonium Ylides

“…5,6 Among this class of compounds, carbonyl sulfoxonium ylides have been the subject of extensive study in recent methodologies and have also found utility in the chemical and pharmaceutical industries. [7][8][9] Their versatility has also been demonstrated in the synthesis of several classes of biologically active organic compounds, including indoles, 10,11 geminal -difunctionalized ketones, 12,13 and pyrroles, 14 among others.…”

Direct Synthesis of α-Fluoro-α-Triazol-1-yl Ketones from Sulfoxonium Ylides: A One-Pot Approach

“…As highlighted with these selected examples, synthetic chemists worldwide have exerted efforts to develop new routes to access α-functionalized ketones . Two distinct subsections of this particular area of chemistry are that of α-azido ketones, and their subsequent applications and transformations, along with α-fluoroketones .…”