Dynamic diagnosis of early gastric cancer with microvascular blood flow rate using magnifying endoscopy (with video): A pilot study

Ueyama, Hiroya; Yatagai, Noboru; Ikeda, Atsushi; Akazawa, Yoichi; Kohno, Hiroyuki; Takeda, Tsutomu; Matsumoto, Keīichi; Matsumoto, Kenshi; Asaoka, Daisuke; Hojo, Mariko; Yao, Takashi; Nagahara, Akihito

doi:10.1111/jgh.15425

Cited by 5 publications

(3 citation statements)

References 23 publications

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“…As described in the Table In a recent study investigating microvascular red blood cell flow speed by using image-enhanced magnifying endoscopy, the data of speed in gastric cancer lesions were significantly slower than in the patchy red non-cancerous lesions (similar finding to cancer). 89 Noboru Yatagai won the Young Investigator Award for this presentation at the 100th symposium of JGES. This "dynamic diagnosis" could…”

Section: Advances In Image-enhanced Endoscopic Diagnosismentioning

confidence: 99%

The role of advanced endoscopy in the management of inflammatory digestive diseases (upper gastrointestinal tract)

Nagahara

Shiotani

Iijima

et al. 2021

Digestive Endoscopy

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The Japan Gastroenterological Endoscopy Society held four serial symposia between 2019 and 2020 on the state-of-the-art of issues related to upper GI inflammatory diseases. This review discusses some of the topics addressed in these symposia. The papers regarding nonerosive reflux disease, recent improvements in intraesophageal pH-impedance monitoring and endoscopic diagnosis using image-enhanced endoscopy have been published. Many publications have addressed its usefulness in endoscopic treatment of gastroesophageal reflux disease such as anti-reflux mucosectomy. In the management of eosinophilic esophagitis, since the symptoms are subjective, objective indicators have been sought, and ultrasonography and highresolution manometry may be useful tools for evaluation. The natural course of this condition, especially of asymptomatic cases, is not well clarified. Some newly developed anti-acid or anti-inflammatory medicines are now under investigation. With regard to autoimmune gastritis, because of widespread medical examinations, diagnosis of asymptomatic cases has been increasing. Recently, its endoscopic characteristics have become clear and the natural history of these conditions is being elucidated. The Kyoto Classification of Gastritis has been reported to be useful not only for Helicobacter pylori diagnosis but also for identification of risks of gastric cancer. Its usefulness is now recognized in Asia and Europe.

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Section: Advances In Image-enhanced Endoscopic Diagnosismentioning

confidence: 99%

The role of advanced endoscopy in the management of inflammatory digestive diseases (upper gastrointestinal tract)

Nagahara

Shiotani

Iijima

et al. 2021

Digestive Endoscopy

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“…Furthermore, magnifying BLI not only enables clear visualization of microvascular structures of the colorectum but also allows real-time visualization of red blood cell (RBC) flow within subepithelial microvessels ( Video 1 ). Mean microvascular blood flow velocity was reported as significantly lower in an early gastric neoplasm than in the surrounding non-neoplastic mucosa 6 . However, microvascular blood flow velocity in the colorectum has not been investigated.…”

Section: Introductionmentioning

confidence: 99%

Novel physiological analysis using blood flow velocity for colonic polyps: Pilot study

Kamba,

Murakami,

Tsugawa

et al. 2024

Endosc Int Open

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Real-time visualization of red blood cell flow inside subepithelial microvessels is performed with magnifying endoscopy. However, microvascular blood flow velocity in the colorectum has not been investigated. Here, we aimed to evaluate the blood flow velocity of microvessels of colonic polyps and to compare it with that of surrounding mucosa. We examined 50 lesions, including 30 adenomas (ADs) and 20 hyperplastic polyps (HPs). Blood flow velocities of lesions and their surrounding mucosa were evaluated using magnifying blue laser imaging (BLI) prior to endoscopic resection. Calculation of mean blood flow velocities was based on mean movement distance of one tagged red blood cell using split video images of magnifying BLI. Mean microvascular blood flow velocity was significantly lower in ADs (1.65 ± 0.66 mm/sec; range 0.46–2.90) than in HPs (2.83 ± 1.10 mm/sec; 1.07-4.50) or the surrounding mucosa (3.73 ± 1.11 mm/sec; 1.80-6.20; P < 0.001). The blood flow velocity rate compared with the surrounding mucosa was significantly lower in ADs (0.41 ± 0.16; 0.10-0.82) than in HPs (0.89 ± 0.25; 0.46-1.51; <i>P</i> < 0.001). We found that mean microvascular blood flow velocity was significantly lower in ADs than in HPs and the surrounding non-neoplastic mucosa. These findings indicate that a novel dynamic approach with microvascular blood flow velocity using magnifying endoscopy may be useful in assessing physiological differences between ADs and HPs.

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“…In recent years, with the development of endoscopic techniques, blue laser endoscopy (BLE) has quickly become one of the most effective methods for the early diagnosis of gastric cancer. [ 4 , 5 , 6 ] Compared with computed tomography (CT), magnetic resonance imaging (MRI) and gastrointestinal radiography, which are traditional methods, BLE with an excitation wavelength range from 410 to 450 nm, is more sensitive to detect EGC by the morphological changes of glandular tubes and blood vessels on the gastric mucosal surface. [ 4 , 7 , 8 , 9 , 10 ] Nevertheless, due to the lack of an image probe for vessels or angiogenesis of tumor under endoscopy, there is still an approximate 25% clinical omission diagnostic rate of EGC by BLE, leading to the loss of the best treatment opportunity for gastric cancer patients.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Anchoring Bis‐Pyrene Probe for Molecular Imaging of Early Gastric Cancer by Endoscopic Techniques

et al. 2022

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With the development of blue laser endoscopy (BLE) technique, it's often used to diagnose early gastric cancer (EGC) by the morphological changes of blood vessels through BLE. However, EGC is still not obvious to identify, resulting in a high rate of missed diagnosis. Molecular imaging can show the changes in early tumors at molecular level, which provides a possibility for diagnosing EGC. Therefore, developing a probe that visually monitors blood vessels of EGC under BLE is particularly necessary. Herein, a bis-pyrene (BP) based nanoprobe (BP-FFVLK-(PEG)-RGD, M 1 ) is designed, which can target angiogenesis and self-assemble into fibers in situ, resulting in stable and long-term retention in tumor. Moreover, M 1 probe can emit yellow-green fluorescence for imaging under BLE. M 1 probe is confirmed to steadily remain in tumor for up to 96 hours in mice transplanted subcutaneously. In addition, the M 1 probe is able to target angiogenesis for molecular imaging of isolated human gastric cancer tissue under BLE. Finally, M 1 probe i.v. injected into primary gastric cancer model rabbits successfully highlighted the tumor site under BLE, which is confirmed by pathological analysis. It's the first time to develop a probe for diagnosing EGC by visualizing angiogenesis under BLE, showing great clinical significance.

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Dynamic diagnosis of early gastric cancer with microvascular blood flow rate using magnifying endoscopy (with video): A pilot study

Cited by 5 publications

References 23 publications

The role of advanced endoscopy in the management of inflammatory digestive diseases (upper gastrointestinal tract)

The role of advanced endoscopy in the management of inflammatory digestive diseases (upper gastrointestinal tract)

Novel physiological analysis using blood flow velocity for colonic polyps: Pilot study

In Vivo Anchoring Bis‐Pyrene Probe for Molecular Imaging of Early Gastric Cancer by Endoscopic Techniques

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