Retraction Note to: NPC-16, a novel naphthalimide–polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells

Xie, Songqiang; Li, Qian; Zhang, Yahong; Wang, Jianhong; Mei, Zi-hou; Zhao, Jin; Wang, Chaojie

doi:10.1007/s10495-021-01658-0

Cited by 1 publication

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“…However only a few reports revealed the roles of host PRRs in regulating virus-elicited ROS production and infection. Significantly, the current coronavirus COVID-19 or severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection was found to induce tissue damage, thrombosis, red blood cell dysfunction and disrupt spermatogenesis through the oxidative stress pathway [ 144 , 145 ]. Respiratory syncytial virus (RSV)-induced oxidative stress is also thought to play a pivotal role in the pathogenesis of RSV-associated lung inflammatory disease [ 146 ].…”

Section: Discussionmentioning

confidence: 99%

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Chang

2021

IJMS

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Oxidative stress is a major contributor to the pathogenesis of various inflammatory diseases. Accumulating evidence has shown that oxidative stress is characterized by the overproduction of reactive oxygen species (ROS). Previous reviews have highlighted inflammatory signaling pathways, biomarkers, molecular targets, and pathogenetic functions mediated by oxidative stress in various diseases. The inflammatory signaling cascades are initiated through the recognition of host cell-derived damage associated molecular patterns (DAMPs) and microorganism-derived pathogen associated molecular patterns (PAMPs) by pattern recognition receptors (PRRs). In this review, the effects of PRRs from the Toll-like (TLRs), the retinoic acid-induced gene I (RIG-I)-like receptors (RLRs) and the NOD-like (NLRs) families, and the activation of these signaling pathways in regulating the production of ROS and/or oxidative stress are summarized. Furthermore, important directions for future studies, especially for pathogen-induced signaling pathways through oxidative stress are also reviewed. The present review will highlight potential therapeutic strategies relevant to inflammatory diseases based on the correlations between ROS regulation and PRRs-mediated signaling pathways.

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Section: Discussionmentioning

confidence: 99%

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Chang

2021

IJMS

View full text Add to dashboard Cite

show abstract

Retraction Note to: NPC-16, a novel naphthalimide–polyamine conjugate, induced apoptosis and autophagy in human hepatoma HepG2 cells and Bel-7402 cells

Cited by 1 publication

References 3 publications

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

Roles of PRR-Mediated Signaling Pathways in the Regulation of Oxidative Stress and Inflammatory Diseases

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