Altered functional network connectivity and working memory dysfunction in adolescents with epilepsy

Vannest, Jennifer; Radhakrishnan, Rupa; Gutierrez‐Colina, Ana M.; Wade, Shari L.; Maloney, Thomas; Combs, Angela; Turnier, Luke; Merder, Shelby; Altaye, Mekibib; Tzipi-Horowitz-Kraus,; Modi, Avani C.

doi:10.1007/s11682-021-00452-5

Cited by 5 publications

(4 citation statements)

References 43 publications

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“…That indicates the surprising increase of overall routing efficiency of working memory network in aSAH patients with working memory deficit, which somehow fails to be in line with former studies (Chung et al, 2019). Previous studies demonstrated that working memory deficit was related with reduced connectivity within the network (Arciniega et al, 2021;Vannest et al, 2021)and other neuron loss or dysfunctionality (Fang et al, 2018;Cheng et al, 2019). Most reports focus on the direct hemodynamic response or adjacent connectivity of regions such as left dorsolateral prefrontal cortex (DLPFC) (Burgess et al, 2010) or parietal cortex (Olesen et al, 2004).…”

Section: Discussionmentioning

confidence: 85%

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Zheng

Zhang

Wan

et al. 2021

Front. Aging Neurosci.

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Aneurysmal subarachnoid hemorrhage (aSAH) is a common disease causing vascular dementia. Survivors often suffer from cognitive impairment especially working memory deficit. Currently, lack of theoretical support limits the improvement of cognitive intervention or rehabilitation. It is unclear how the large-scale network differs and to what extent is the brain network affected? Our study aims to provide novel information about the topological characteristics of brain organization, especially “small-world” property. A total of 62 aSAH patients are enrolled in this study. They are divided into two groups according to the syndrome of working memory deficit. Their working memory function is evaluated by TMT-B and AVLT (Chinese version). Functional MRI scan is also performed for detecting resting-state cortical plasticity. We utilized ICA to extract functional sub-networks including working memory network from imaging data. And then we establish binarized network and calculate the small-worldness property as well as local and global efficiency of networks. aSAH group with working memory deficit shows no significant difference of clustering coefficient with control group. Our study discovered significant decrease of characteristic path length indicating an increase of overall routing efficiency. We reason that patients with working memory deficit have to recruit more neuronal resources and thus develops higher overall routing efficiency of local network. This study provides novel information about the neural alterations of aSAH patients with working memory deficit. It might contribute to the understanding of neural mechanism and the improvement of current intervention for vascular dementia.

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Section: Discussionmentioning

confidence: 85%

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Zheng

Zhang

Wan

et al. 2021

Front. Aging Neurosci.

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“…In a functional magnitude resonance imaging (fMRI) study examining brain connectivity during a verbal working memory task, adolescents compared to children showed increasing functional connectivity as cognitive load increased [29]. Another study found that adolescents at risk for working memory deficits had decreased connectivity between the left frontal operculum and the anterior cingulate gyrus compared to the control group [30]. A more recent dynamic functional connectivity study found that brain states with high activity in the frontal-parietal network (FPN) during working memory were short-lived and recurring [31].…”

Section: Adolescent Memorymentioning

confidence: 99%

Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders

Etami,

Lildharrie,

Manza

et al. 2023

Genes

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Trauma in childhood and adolescence has long-term negative consequences in brain development and behavior and increases the risk for psychiatric disorders. Among them, post-traumatic stress disorder (PTSD) during adolescence illustrates the connection between trauma and substance misuse, as adolescents may utilize substances to cope with PTSD. Drug misuse may in turn lead to neuroadaptations in learning processes that facilitate the consolidation of traumatic memories that perpetuate PTSD. This reflects, apart from common genetic and epigenetic modifications, overlapping neurocircuitry engagement triggered by stress and drug misuse that includes structural and functional changes in limbic brain regions and the salience, default-mode, and frontoparietal networks. Effective strategies to prevent PTSD are needed to limit the negative consequences associated with the later development of a substance use disorder (SUD). In this review, we will examine the link between PTSD and SUDs, along with the resulting effects on memory, focusing on the connection between the development of an SUD in individuals who struggled with PTSD in adolescence. Neuroimaging has emerged as a powerful tool to provide insight into the brain mechanisms underlying the connection of PTSD in adolescence and the development of SUDs.

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“…In a functional magnitude resonance imaging (fMRI) study examining brain connectivity during a verbal working memory task, adolescents compared to children showed increasing functional connectivity as cognitive load increased (van den Bosch et al, 2014). Another study found that adolescents at risk for working memory deficits had decreased connectivity between the left frontal operculum and the anterior cingulate gyrus compared to the control group (Vannest et al, 2021). A more recent dynamic functional connectivity study found that brain states with high activity in the frontal-parietal network (FPN) during working memory were short-lived and recurring (He et al, 2023).…”

Section: Adolescent Memorymentioning

confidence: 99%

Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders

Etami,

Lildharrie,

Manza

et al. 2023

Preprint

View full text Add to dashboard Cite

Trauma in childhood and adolescence has long-term negative consequences in brain development and behavior and increases the risk for psychiatric disorders. Among them, post-traumatic stress disorder (PTSD) during adolescence illustrates the connection between trauma and substance misuse, as adolescents may utilize substances to cope with PTSD. Drug misuse may in turn lead to neuroadaptations in learning processes that facilitate the consolidation of traumatic memories that perpetuate PTSD. This reflects, apart from common genetic and epigenetic modifications, overlapping neurocircuitry engagement triggered by stress and drug misuse that includes structural and functional changes in limbic brain regions and the salience, default-mode, and frontoparietal networks. Effective strategies to prevent PTSD are needed to limit the negative consequences associated with the later development of a substance use disorder (SUD). In this review, we will examine the link between PTSD and SUDs, along with the resulting effects on memory, focusing on the connection between the development of a SUD in individuals who struggled with PTSD in adolescence. Neuroimaging has emerged as a powerful tool to provide insight into the brain mechanisms underlying the connection of PTSD in adolescence and the development of SUDs.

show abstract

Altered functional network connectivity and working memory dysfunction in adolescents with epilepsy

Cited by 5 publications

References 43 publications

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Topological Alterations of Working Memory Impairment in Aged Patients With Vascular Dementia

Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders

Neuroimaging in Adolescents: Post-Traumatic Stress Disorder and Risk for Substance Use Disorders

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