MYC and NOTCH1‐positive postradiation cutaneous angiosarcoma of the breast

Sheu, Tiffany G.; Hunt, Kelly K.; Middleton, Lavinia P.

doi:10.1111/tbj.14171

Cited by 4 publications

(1 citation statement)

References 8 publications

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“…H3K27me3 is an epigenomic chemical marker that is added to proteins called histones. Histones form chromatin, which plays an important role in the regulation of gene expression [ 8 ]. H3K27me3 is a histone in which a methyl group is added to the specific amino acid lysine 27 of histone H3.…”

Section: Discussionmentioning

confidence: 99%

Radiation-Associated Breast Angiosarcoma

Yoshino,

Yoshida,

Ujiie

et al. 2023

Cureus

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Radiation-associated breast angiosarcomas are rare following breast-conserving surgery. These angiosarcomas are considered adverse events associated with radiation therapy and are characterized by a high risk of both local and distant recurrence, even after complete resection. Despite this, there is currently no established standard treatment for them. The patient was a 70-year-old woman who had breast-conserving surgery for right breast cancer 10 years before presentation. She was followed up for 10 years after receiving 50 Gy of residual breast irradiation and an aromatase inhibitor for 5 years. During follow-up, a painless purplish area with induration, measuring 10 cm by 5.4 cm, was noted on the right nipple. A skin biopsy confirmed hemangiosarcoma. Treatment included surgery with a 2.0 cm margin from the area, followed by skin excision and total mastectomy. A final diagnosis of radiation-associated breast angiosarcoma was made. Radiation-associated breast angiosarcoma is a rare disease with a poor prognosis that lacks standard treatment. An aggressive skin biopsy should be considered when skin findings such as purpura are seen after breast cancer radiotherapy, as in this case.

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Section: Discussionmentioning

confidence: 99%