The Association of Acute Cerebrospinal Fluid Pressure Reduction with Choroidal Thickness

Liu, Xiangxiang; Khodeiry, Mohamed M.; Lin, Danting; Sun, Yang; Chen, Lin; Feng, Wei; Li, Jing; Wang, Yaxing; Zhang, Qing; Cao, Kai; Wang, Jiawei; Wang, Ke

doi:10.1080/02713683.2021.1874024

Cited by 2 publications

(3 citation statements)

References 30 publications

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“…We collected the fundus photographs at day 1, day 4, and day 7 after CSFP reduction modeling in rats, and it was observed that the mean diameters of the retinal artery and vein gradually narrowed, and the vessel diameter changes were more apparent in the retinal artery than in the vein [37]. Apart from retinal blood vessels, a significant decrease in the subfoveal choroidal thickness has also been observed 15 min after diagnostic lumbar puncture in human subjects in another study [38]. Similarly, some clinical studies reported a narrower retinal diameter in glaucoma patients when compared with a healthy population, and the sites of retinal vascular stenosis are usually accompanied by a thinner RNFL.…”

Section: Basic Research Of “Dual‐pressure Theory”mentioning

confidence: 99%

“Dual‐pressure theory” in pathogenesis of glaucomatous optic neuropathy from the Beijing intracranial and intraocular pressure study

Cheng,

Yusufu,

Weinreb

et al. 2024

Eye & ENT Research

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The mechanical theory of glaucoma indicates that high intraocular pressure (IOP) leads to glaucomatous optic nerve damage. However, nearly half of primary open‐angle glaucoma patients with normal intraocular pressure also exhibit progression of what appears to be glaucomatous optic nerve damage. Our earlier prospective study identified for the first time that the relatively low intracranial pressure (ICP) is also an important risk factor for progressive glaucomatous injury of normal‐tension glaucoma. When considering the results of studies in nonhuman primates, clinical research, large‐scale natural‐population studies, and basic laboratory investigations, a new understanding of the pathophysiology of glaucoma, the “Dual‐Pressure Theory”, has been proposed. This theory states that “either high IOP or low ICP contributes to increasing the translaminar cribrosa pressure difference; it is the pressure difference rather than the IOP alone that results in the glaucomatous optic neuropathy”. Here, we provide a systematic introduction to Dual‐Pressure Theory relating to glaucoma, the form of a research map, an outline of basic laboratory investigations, the main methodology, and research updates.

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Section: Basic Research Of “Dual‐pressure Theory”mentioning

confidence: 99%

“Dual‐pressure theory” in pathogenesis of glaucomatous optic neuropathy from the Beijing intracranial and intraocular pressure study

Cheng,

Yusufu,

Weinreb

et al. 2024

Eye & ENT Research

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“…This enables an improved assessment of the choroid including the choriocapillaris and the choroidoscleral interface. 11 , 12 …”

Section: Introductionmentioning

confidence: 99%

“…This enables an improved assessment of the choroid including the choriocapillaris and the choroidoscleral interface. 11,12 Peripapillary atrophy (PPA) is typically a lighter colored, well-demarcated crescent-shaped area on the temporal side of the optic nerve head and can be clinically divided into a central beta zone and peripheral alpha zone. 13 These two zones are not always present together.…”

Section: Introductionmentioning

confidence: 99%

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

Khodeiry¹,

Liu²,

Sayed³

et al. 2021

OPTH

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Purpose Peripapillary halos (PPH) are peripapillary changes observed surrounding the optic nerve head in normal eyes and eyes with different disorders. Recognizing the microstructure and mechanism of development of these halos will help clinicians understand the different associated retinal and optic nerve head pathologies. We describe the in vivo histological characteristics of PPH in birdshot chorioretinopathy (BSCR). Patients and Methods This was a prospective observational case-series in a single tertiary referral center. Six eyes of three patients with PPH associated with BSCR were determined through clinical examination, fundus photography, and fundus autofluorescence (FAF). Patients underwent swept-source optical coherence tomography (SS-OCT) imaging of the optic nerve head and peripapillary region. Results In SS-OCT B-scans across the area of PPH, we observed thinning and interruption of retinal pigment epithelium (RPE)-Bruch’s membrane complex. These halos are a circumferential form of alpha zone RPE-associated crescentic peripapillary atrophy (PPA), unlike the PPH observed with myopia and normal aging. Conclusion PPH in BSCR patients may be a sign of prior inflammatory optic neuropathy.

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The Association of Acute Cerebrospinal Fluid Pressure Reduction with Choroidal Thickness

Cited by 2 publications

References 30 publications

“Dual‐pressure theory” in pathogenesis of glaucomatous optic neuropathy from the Beijing intracranial and intraocular pressure study

“Dual‐pressure theory” in pathogenesis of glaucomatous optic neuropathy from the Beijing intracranial and intraocular pressure study

Peripapillary Halo in Inflammatory Papillitis of Birdshot Chorioretinopathy

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