The potential of biomaterials for central nervous system cellular repair

Jarrin, Sarah; Cabré, Sílvia; Dowd, Eilís

doi:10.1016/j.neuint.2021.104971

Cited by 22 publications

(22 citation statements)

References 110 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, direct transplanted neural stem cells do not have physical support in the injured area to fill the lesion and the lack of microenvironment for cell growth and differentiation, making the survival rate of neural stem cells after transplantation extremely low. Hydrogels have adjustable physical and chemical properties to fill irregular pathological cavities in the brain and provide a favorable microenvironment for the growth and proliferation of nerve cells [ 96 ]. Self-healing hydrogels can achieve self-healing of nerves’ mechanical damage, maintain the integrated structure of nerve regeneration, and maintain long-term transplant structural integrity and persistence ( Table 5 ) ( Figure 7 ).…”

Section: Application Of Self-healing Hydrogels In Tissue Engineeringmentioning

confidence: 99%

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Liang

Yuan

et al. 2022

Polymers

View full text Add to dashboard Cite

Self-healing hydrogels and traditional hydrogels both have three-dimensional polymeric networks that are capable of absorbing and retaining a large amount of water. Self-healing hydrogels can heal and restore damage automatically, and they can avoid premature failure of hydrogels caused by mechanical damage after implantation. The formation mechanism of self-healing hydrogels and the factors that hydrogels can load are various. Researchers can design hydrogels to meet the needs of different tissues through the diversity of hydrogels Therefore, it is necessary to summarize different self-healing mechanisms and different factors to achieve different functions. Here, we briefly reviewed the hydrogels designed by researchers in recent years according to the self-healing mechanism of water coagulation. Then, the factors for different functions of self-healing hydrogels in different tissues were statistically analyzed. We hope our work can provide effective support for researchers in the design process of self-healing hydrogel.

show abstract

Section: Application Of Self-healing Hydrogels In Tissue Engineeringmentioning

confidence: 99%

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Liang

Yuan

et al. 2022

Polymers

View full text Add to dashboard Cite

show abstract

“…Theranostic based nanotechnology (use of radioactive drugs for diagnosis and therapy) further widens the window of possible applications in precision drug delivery systems. Nanomaterials are the only agent through which minimal doses of medicines can be effectively used for achieving best outcomes ( Zhong and Bellamkonda, 2008 ; Niemczyk et al, 2018 ; Jarrin et al, 2021 ). The advantages of the use of biomaterials in treatment of neurological disorders can be summarized in the following points.…”

Section: Advantages Of Nanomaterials For Central Nervous System Applicationsmentioning

confidence: 99%

Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders

Khan

Rudrapal²,

Bhat

et al. 2021

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

The significance of biomaterials is well appreciated in nanotechnology, and its use has resulted in major advances in biomedical sciences. Although, currently, very little data is available on the clinical trial studies for treatment of neurological conditions, numerous promising advancements have been reported in drug delivery and regenerative therapies which can be applied in clinical practice. Among the commonly reported biomaterials in literature, the self-assembling peptides and hydrogels have been recognized as the most potential candidate for treatment of common neurological conditions such as Alzheimer’s, Parkinson’s, spinal cord injury, stroke and tumors. The hydrogels, specifically, offer advantages like flexibility and porosity, and mimics the properties of the extracellular matrix of the central nervous system. These factors make them an ideal scaffold for drug delivery through the blood-brain barrier and tissue regeneration (using stem cells). Thus, the use of biomaterials as suitable matrix for therapeutic purposes has emerged as a promising area of neurosciences. In this review, we describe the application of biomaterials, and the current advances, in treatment of statistically common neurological disorders.

show abstract

“…Additionally, hydrogels exhibit highly adjustable physical characteristics, including degradability, mechanical strength, gelation duration, and gelation temperature [11,15]. Hydrogels have been extensively employed in biosensing, cell encapsulation, drug delivery, and tissue engineering scaffolds, among other applications, including but not limited to the area of neurodegenerative disease [16,17].…”

Section: Introductionmentioning

confidence: 99%

Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis

2022

View full text Add to dashboard Cite

Multiple sclerosis (MS) is a chronic demyelinating disease of the central nervous system. This disorder may cause progressive and permanent impairment, placing significant physical and psychological strain on sufferers. Each progress in MS therapy marks a significant advancement in neurological research. Hydrogels can serve as a scaffold with high water content, high expansibility, and biocompatibility to improve MS cell proliferation in vitro and therapeutic drug delivery to cells in vivo. Hydrogels may also be utilized as biosensors to detect MS-related proteins. Recent research has employed hydrogels as an adjuvant imaging agent in immunohistochemistry assays. Following an overview of the development and use of hydrogels in MS diagnostic and therapy, this review discussed hydrogel’s advantages and future opportunities in the diagnosis and treatment of MS. Graphical abstract

show abstract

The potential of biomaterials for central nervous system cellular repair

Cited by 22 publications

References 110 publications

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Mechanism of Self-Healing Hydrogels and Application in Tissue Engineering

Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders

Potential application of hydrogel to the diagnosis and treatment of multiple sclerosis

Contact Info

Product

Resources

About