Synthesis of Layered Double Hydroxides Intercalated With Drugs for Controlled Release: Successful Intercalation of Ibuprofen and Failed Intercalation of Paracetamol

Carboxymethylcellulose/layered double hydroxide dispersions for topical ocular delivery of non-steroidal anti-inflammatory drugs

“…26 The intercalation of NSAIDs significantly decreased the 2 θ values of (0 0 l) peaks, resulting in the following interlayer distance values: 21.9 Å for LDH-IB, 22.7 Å for LDH-KP, and 23.7 Å for LDH-KL. These values were similar to those previously obtained for LDHs intercalated with ibuprofen 27–29 and ketoprofen. 16,30,31 The poor intensity and the width of the peaks indicated that the samples had lower crystallinity compared to LDH-Cl.…”

“…This absence indicates that the NSAIDs are incorporated almost exclusively in its basic, anionic form. Finally, the FT-IR spectra of the samples showed specific bands of each NSAID: LDH-IB at 1365 cm −1 ( ν C–C–H ), 1512 cm −1 ( ν C–C,ring ) and 1065 cm −1 ( ν C–C ); 29 LDH-KP, at 1656 cm −1 ( ν C=O, ketone ) and 1448 cm −1 ( δ CH 2 ) 30,36 and finally LDH-KL, at 1279 cm −1 ( δ CH 2 ) and 723 cm −1 ( δ C–C–C ). 37…”

Pharmaceutical compounds photolysis: pH influence

“…In the case of paracetamol, it was possible to observe a redshift in the absorption spectrum as the pH approaches the value of pKa = 9.4 [ 24 ], the redshift being much more pronounced for the case pH = 11 (pH > pKa), inserted in the graph for comparison purposes ( Fig. 6 c).…”

Biomaterials Based on Organic Polymers and Layered Double Hydroxides Nanocomposites: Drug Delivery and Tissue Engineering

“…For example, LDHs can intercalate bioactive species establishing arrangements and physical interactions that favor solubilization compared to those ones in the pristine drug crystal. Many drugs, such as the anti-inflammatories ibuprofen [ 202 ] and zaltoprofen [ 203 ], the diuretic piretanide [ 204 ], and the vitamin B3 (nicotinic acid) [ 205 ], among others, were manipulated by intercalation into LDH to overcome the low solubility challenge. The solubility test of zaltoprofen in water and phosphate buffer (pH equal to 6.8) showed that its intercalation into Zn R Al-LDH improved three times its solubility compared to the non-intercalated drug [ 203 ] and presented better performance than the physical mixture of zaltoprofen and LDH, demonstrating the benefits of the DDS approach.…”