Log odds of positive lymph nodes is a better prognostic factor for oesophageal signet ring cell carcinoma than N stage

Wang, Feng; Gao, Shugeng; Xue, Qi; Tan, Fengwei; Gao, Yushun; Mao, Yousheng; Wang, Dali; Zhao, Jun; Li, Yin; Yu, Xiangyang; Cheng, Hong; Zhao, Chenguang; Mu, Jianjun

doi:10.12998/wjcc.v9.i1.24

Cited by 1 publication

(2 citation statements)

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Section: Discussionmentioning

confidence: 99%

“…Several studies have shown the strong prognostic ability of LODDS in SRCC ( 12 , 20 ). In a cohort study, Wang et al found that, compared with the pN stage, LODDS was a highly reliable index with a good predictive performance for the OS and CSS of patients with esophageal SRCC ( 20 ). Xu et al enrolled 1,365 patients with gastric SRCC and developed a prognostic nomogram based on LODDS, which provided a more satisfying predictive capacity both in the OS and CSS than AJCC TNM stage alone ( 12 ).…”

Section: Discussionmentioning

confidence: 99%

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Prognostic value of log odds of positive lymph nodes, lymph node ratio, and N stage in patients with colorectal signet ring cell carcinoma: A retrospective cohort study

Hu¹,

Jiang²,

Wu³

et al. 2023

Front. Surg.

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AimLittle attention has been paid in the prognosis of colorectal signet ring cell carcinoma (SRCC). This study aims to explore the predictive capacity of log odds of positive lymph nodes (LODDS), lymph node ratio (LNR), and pN stage in the prognosis of patients with colorectal SRCC.MethodsA retrospective cohort study was designed, and data were extracted from the Surveillance, Epidemiology and End Results (SEER) database. Data on demographic characteristics, clinicopathological features, and treatment were extracted. Outcomes were overall survival (OS) and cancer-specific survival (CSS). Association of LODDS, LNR, and pN stage with OS and CSS were explored using Cox proportional hazard model and Cox competing risk model, respectively, with results showing as hazard ratio and 95% confidence interval (CI). Predictive performance of LODDS, LNR, and pN stage in OS and CSS was assessed by calculating C-index.ResultsA total of 2,198 patients were included in this study. LODDS, LNR, and pN stage were associated with the OS and CSS of colorectal SRCC patients (all P < 0.05). LODDS showed a good performance in the OS (C-index: 0.704, 95% CI: 0.690–0.718), which was superior to LNR (C-index: 0.657, 95% CI: 0.643–0.671) and pN stage (C-index: 0.643, 95% CI: 0.629–0.657). The C-index of LODDS, LNR, and pN stage for CSS was 0.733 (95% CI: 0.719–0.747), 0.713 (95% CI: 0.697–0.729), and 0.667 (95% CI: 0.651–0.683), respectively.ConclusionsLODDS displayed a better predictive capacity in the OS and CSS than LNR and pN stage, indicating that LODDS may be effective to predict the prognosis of colorectal SRCC in the clinic.

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Section: Discussionmentioning

confidence: 99%