Corrigendum: Low Lymphocyte Count Is Associated With Radiotherapy Parameters and Affects the Outcomes of Esophageal Squamous Cell Carcinoma Patients

Wang, Xin; Zhao, Zhenwei; Geng, Xiaotao; Zhu, Lu; Li, Minghuan

doi:10.3389/fonc.2020.630877

Cited by 1 publication

(1 citation statement)

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“…Lymphocytes are particularly sensitive to radiation. For example, RT leads to a decrease in the number of innate immune response lymphocytes in esophageal squamous cell carcinoma (ESCC) [146]. RT causes oxidative damage, and employing antioxidants such as superoxide dismutase, glutathione peroxidase, and catalase can protect innate immune cells from radiation-induced oxidative damage [147].…”

Section: Enhancing Radiation Efficiency and Maintaining Innate Immune...mentioning

confidence: 99%

Innate Immune System in the Context of Radiation Therapy for Cancer

Boopathi

Den

Thangavel

2023

Cancers

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Radiation therapy (RT) remains an integral component of modern oncology care, with most cancer patients receiving radiation as a part of their treatment plan. The main goal of ionizing RT is to control the local tumor burden by inducing DNA damage and apoptosis within the tumor cells. The advancement in RT, including intensity-modulated RT (IMRT), stereotactic body RT (SBRT), image-guided RT, and proton therapy, have increased the efficacy of RT, equipping clinicians with techniques to ensure precise and safe administration of radiation doses to tumor cells. In this review, we present the technological advancement in various types of RT methods and highlight their clinical utility and associated limitations. This review provides insights into how RT modulates innate immune signaling and the key players involved in modulating innate immune responses, which have not been well documented earlier. Apoptosis of cancer cells following RT triggers immune systems that contribute to the eradication of tumors through innate and adoptive immunity. The innate immune system consists of various cell types, including macrophages, dendritic cells, and natural killer cells, which serve as key mediators of innate immunity in response to RT. This review will concentrate on the significance of the innate myeloid and lymphoid lineages in anti-tumorigenic processes triggered by RT. Furthermore, we will explore essential strategies to enhance RT efficacy. This review can serve as a platform for researchers to comprehend the clinical application and limitations of various RT methods and provides insights into how RT modulates innate immune signaling.

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Section: Enhancing Radiation Efficiency and Maintaining Innate Immune...mentioning

confidence: 99%