Abstract:Objectives: To explore factors from the acute phase, and after three and 12 months, associated with level of self-reported physical activity 12 months after a minor ischemic stroke with National Institutes of Health Stroke Scale (NIHSS) score 3 in persons 70 years or younger. Materials and method: In this longitudinal cohort study patients were recruited consecutively from two stroke units. Activity level were measured with three sets of questions addressing the average number of frequency (times exercising ea… Show more
“…Overall, the study population had low physical activity levels, with approximately half of the participants being inactive. Among those who increased their physical activity, only a small number ( Figure 1 ) engaged in moderate- to vigorous-intensity exercise, which was a lower percentage than what has been reported in previous studies (approximately 40% active), 9 , 29 , 30 despite most participants experiencing a mild stroke. The decreaser group had a maximum decrease rate between 1 and 3 months and was followed by a plateau, which was consistent with results from previous studies.…”
ImportanceThe optimum level and timing of poststroke physical activity interventions to enhance functional recovery remain unclear.ObjectiveTo assess the level of physical activity in the first 6 months after stroke among individuals with similar physical activity patterns over time and to investigate the association between physical activity trajectories and functional recovery at 6 months after stroke.Design, Setting, and ParticipantsThis cohort study obtained data from the Efficacy of Fluoxetine–a Randomized Controlled Trial in Stroke, which was conducted in 35 stroke and rehabilitation centers across Sweden from October 2014 to June 2019. Adult participants (aged >18 years) were recruited between 2 and 15 days after stroke onset and followed up for 6 months. Participants who withdrew or were lost to follow-up were excluded from the longitudinal analysis. Data analyses were performed between August 15 and October 28, 2022.ExposuresPhysical activity was assessed at 1 week, 1 month, 3 months, and 6 months. Multiple factors associated with physical activity trajectories were investigated. Association of the distinct trajectories with functional recovery was assessed in multivariable logistic regression.Main Outcomes and MeasuresThe primary outcomes were the distinct physical activity trajectories over time, which were identified using group-based trajectory modeling. The secondary outcome was the functional recovery at 6 months after stroke, which was assessed using the modified Rankin Scale.ResultsOf the 1367 included participants (median [IQR] age, 72 years [65-79] years; 844 males [62%]), 2 distinct trajectory groups were identified: increaser (n = 720 [53%]) and decreaser (647 [47%]). The increaser group demonstrated a significant increase in physical activity level (mean difference, 0.27; linear slope β1 = 0.46; P < .001) and sustained it at light intensity from 1 week to 6 months, whereas the decreaser group showed a decline in physical activity and eventually became inactive (mean difference, −0.26; linear slope β1 = 1.81; P < .001). Male participants and those with normal cognition had higher odds of being in the increaser group, regardless of stroke severity. Increasing physical activity and sustaining it at light intensity were associated with a good functional outcome at 6 months (adjusted odds ratio, 2.54; 99% CI, 1.72-3.75; P < .001).Conclusions ad RelevanceResults of this study suggest that increased physical activity was associated with functional recovery 6 months after stroke. Interventions targeting individuals with decreasing physical activity in the subacute phase of stroke may play a role in improved functional outcomes.
“…Overall, the study population had low physical activity levels, with approximately half of the participants being inactive. Among those who increased their physical activity, only a small number ( Figure 1 ) engaged in moderate- to vigorous-intensity exercise, which was a lower percentage than what has been reported in previous studies (approximately 40% active), 9 , 29 , 30 despite most participants experiencing a mild stroke. The decreaser group had a maximum decrease rate between 1 and 3 months and was followed by a plateau, which was consistent with results from previous studies.…”
ImportanceThe optimum level and timing of poststroke physical activity interventions to enhance functional recovery remain unclear.ObjectiveTo assess the level of physical activity in the first 6 months after stroke among individuals with similar physical activity patterns over time and to investigate the association between physical activity trajectories and functional recovery at 6 months after stroke.Design, Setting, and ParticipantsThis cohort study obtained data from the Efficacy of Fluoxetine–a Randomized Controlled Trial in Stroke, which was conducted in 35 stroke and rehabilitation centers across Sweden from October 2014 to June 2019. Adult participants (aged >18 years) were recruited between 2 and 15 days after stroke onset and followed up for 6 months. Participants who withdrew or were lost to follow-up were excluded from the longitudinal analysis. Data analyses were performed between August 15 and October 28, 2022.ExposuresPhysical activity was assessed at 1 week, 1 month, 3 months, and 6 months. Multiple factors associated with physical activity trajectories were investigated. Association of the distinct trajectories with functional recovery was assessed in multivariable logistic regression.Main Outcomes and MeasuresThe primary outcomes were the distinct physical activity trajectories over time, which were identified using group-based trajectory modeling. The secondary outcome was the functional recovery at 6 months after stroke, which was assessed using the modified Rankin Scale.ResultsOf the 1367 included participants (median [IQR] age, 72 years [65-79] years; 844 males [62%]), 2 distinct trajectory groups were identified: increaser (n = 720 [53%]) and decreaser (647 [47%]). The increaser group demonstrated a significant increase in physical activity level (mean difference, 0.27; linear slope β1 = 0.46; P < .001) and sustained it at light intensity from 1 week to 6 months, whereas the decreaser group showed a decline in physical activity and eventually became inactive (mean difference, −0.26; linear slope β1 = 1.81; P < .001). Male participants and those with normal cognition had higher odds of being in the increaser group, regardless of stroke severity. Increasing physical activity and sustaining it at light intensity were associated with a good functional outcome at 6 months (adjusted odds ratio, 2.54; 99% CI, 1.72-3.75; P < .001).Conclusions ad RelevanceResults of this study suggest that increased physical activity was associated with functional recovery 6 months after stroke. Interventions targeting individuals with decreasing physical activity in the subacute phase of stroke may play a role in improved functional outcomes.
“…Previous studies (Fens et al., 2013; McHutchison et al., 2019) found that about 50% of patients with MIS showed a decline in their ability in daily work and to return to society, and about 40% of patients with MIS had cognitive dysfunction and communication difficulties. MIS is a type of stroke characterized by mild symptoms and short duration that rarely causes neurological deficits (Hamre et al., 2021), which are more likely to be overlooked. However, the higher incidence of PSCI in MIS patients would also bring serious harm to our society (Fens et al., 2013; McHutchison et al., 2019).…”
Background: Mild ischemic stroke (MIS) has been proved to be closely related to poststroke cognitive impairment (PSCI). However, there are relatively few studies on the risk factors of MIS. We aimed to evaluate the relationship between serum cystatin C (CysC) level and cognitive function in patients with acute MIS.
Methods: Four hundred consecutive patients with acute MIS were screened and 281 patients were eligible for this study. The serum CysC levels were detected within 24 h after admission. Cognitive function was assessed by Montreal Cognitive Assessment (MoCA) at 3 months after acute MIS. Logistic regression was used to identify the predictors of PSCI, and the receiver operating characteristic (ROC) curve was applied to explore the optimal cut-off value.Results: One hundred sixty-four (58.4%) patients were diagnosed with PSCI at 3 months follow-up. The serum CysC levels in patients with PSCI were significantly higher than patients without PSCI (p < .001). The binary logistic regression analysis showed that higher serum CysC level was an independent predictor for PSCI at 3 months (odds ratio [OR], 5.745; 95% confidence interval, [CI], 1.089-30.311; p = 0.039). The ROC curve showed that area under the curve (AUC) was 0.723, and at a 0.945 mg/l CysC cut-off point, the sensitivity and specificity for PSCI at 3 months were 79.9% and 58.1%, respectively.
Conclusion:Our findings suggested that the serum CysC levels were increased after acute MIS, and higher serum CysC levels at baseline might be an independent risk factor for PSCI in patients with acute MIS, but further research are warranted.
“…Due to the heavy burden of stroke mortality around the world, actions to prevent this neurological disorder are fundamental to the quality of life of the population. Among actions for stroke prevention, physical activity stands out in a preventive and therapeutic way in stroke survivors 4 . A systematic review with meta-analysis found 26 articles that analyzed the dose-response relationship between physical activity and stroke 5 .…”
Introduction: This study aimed to estimate the burden of stroke mortality due to low levels of physical activity (PA) in Brazil from 1990 to 2019. Methods: Data from the 2019 Global Burden of Disease (GBD) study for Brazil and Brazilian states were used. We used the number of deaths, age-standardized mortality rates, summary exposure value, and fraction of population risk attributable to low levels of PA. To standardize all estimates, data from the population aged 25 years or older were considered. Results: The risk of exposure to low PA, SEV values, for the Brazilian male population was 11.
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