Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis

Pham, Le Minh; Kim, Eok-Cheon; Ou, Wenquan; Phung, Cao Dai; Nguyen, Hanh Thuy; Pham, Thanh Tung; Poudel, Kishwor; Gautam, Milan; Jeong, Jee–Heon; Yong, Chul Soon; Park, Soyoung; Kim, Jae‐Ryong; Kim, Jong Oh

doi:10.1016/j.biomaterials.2021.120677

Cited by 71 publications

(55 citation statements)

References 45 publications

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“…In human atherosclerotic lesions, most Mφs in plaques exhibited CD9 immunoreactivity (Nishida et al, 2000). In hyperlipidemic ApoE −/− mice, selective delivery of the anti-senescence drug rosuvastatin to the atherosclerotic plaques using nanoparticles alleviated the progression of AS (Kim et al, 2021). Recent studies indicate that certain immune cells, in particular iNKT cells, can function to remove senescent cells (Kale et al, 2020;Arora et al, 2021).…”

Section: Macrophage Senescence In Atherosclerosismentioning

confidence: 99%

Roles of Macrophages in Atherogenesis

Farahi¹,

Sinha

Lusis

2021

Front. Pharmacol.

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Atherosclerosis is a chronic inflammatory disease that may ultimately lead to local proteolysis, plaque rupture, and thrombotic vascular disease, resulting in myocardial infarction, stroke, and sudden cardiac death. Circulating monocytes are recruited to the arterial wall in response to inflammatory insults and differentiate into macrophages which make a critical contribution to tissue damage, wound healing, and also regression of atherosclerotic lesions. Within plaques, macrophages take up aggregated lipoproteins which have entered the vessel wall to give rise to cholesterol-engorged foam cells. Also, the macrophage phenotype is influenced by various stimuli which affect their polarization, efferocytosis, proliferation, and apoptosis. The heterogeneity of macrophages in lesions has recently been addressed by single-cell sequencing techniques. This article reviews recent advances regarding the roles of macrophages in different stages of disease pathogenesis from initiation to advanced atherosclerosis. Macrophage-based therapies for atherosclerosis management are also described.

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Section: Macrophage Senescence In Atherosclerosismentioning

confidence: 99%

Roles of Macrophages in Atherogenesis

Farahi¹,

Sinha

Lusis

2021

Front. Pharmacol.

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“…On the same note, another team of researchers used mesoporous silica-coated nanoparticles, coated with hyaluronic acid and functionalized with CD9 antibodies and rosuvastatin as a drug, in order to target senescent atherosclerotic plaques, which are mostly made up of endothelial cells and macrophages. The use of CD9 antibodies led to a high uptake of the nanocomplex and overall, promising therapeutic use [ 87 ].…”

Section: Nanoparticles and Extracellular Vesiclesmentioning

confidence: 99%

Tetraspanins: Physiology, Colorectal Cancer Development, and Nanomediated Applications

Ţîţu

Grapa

Mocan

et al. 2021

Cancers

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Tetraspanins are transmembrane proteins expressed in a multitude of cells throughout the organism. They contribute to many processes that surround cell–cell interactions and are associated with the progress of some diseases, including cancer. Their crucial role in cell physiology is often understated. Furthermore, recent studies have shown their great potential in being used as targeting molecules. Data have suggested the potential of tetraspanins as a targeting vector for nanomediated distribution and delivery for colorectal cancer applications. Our aim is to provide a review on the important part that tetraspanins play in the human organism and highlight their potential use for drug delivery systems using nanotechnology.

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“…Atherosclerotic cardiovascular disease (ASCVD) is a major cause of mortality in many industrialized societies ( Commodore-Mensah et al, 2021 ). Lipid accumulation, local inflammatory responses, and endothelial injury are important factors in the development of atherosclerosis ( Pham et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

Yang

Xing

et al. 2021

Front. Cell Dev. Biol.

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Cardiovascular disease (CVD) is the main cause of death worldwide. Atherosclerosis is the underlying pathological basis of CVD. Mitochondrial homeostasis is maintained through the dynamic processes of fusion and fission. Mitochondria are involved in many cellular processes, such as steroid biosynthesis, calcium homeostasis, immune cell activation, redox signaling, apoptosis, and inflammation, among others. Under stress conditions, mitochondrial dynamics, mitochondrial cristae remodeling, and mitochondrial ROS (mitoROS) production increase, mitochondrial membrane potential (MMP) decreases, calcium homeostasis is imbalanced, and mitochondrial permeability transition pore open (mPTP) and release of mitochondrial DNA (mtDNA) are activated. mtDNA recognized by TLR9 can lead to NF-κB pathway activation and pro-inflammatory factor expression. At the same time, TLR9 can also activate NLRP3 inflammasomes and release interleukin, an event that eventually leads to tissue damage and inflammatory responses. In addition, mitochondrial dysfunction may amplify the activation of NLRP3 through the production of mitochondrial ROS, which together aggravate accumulating mitochondrial damage. In addition, mtDNA defects or gene mutation can lead to mitochondrial oxidative stress. Finally, obesity, diabetes, hypertension and aging are risk factors for the progression of CVD, which are closely related to mitochondrial dynamics. Mitochondrial dynamics may represent a new target in the treatment of atherosclerosis. Antioxidants, mitochondrial inhibitors, and various new therapies to correct mitochondrial dysfunction represent a few directions for future research on therapeutic intervention and amelioration of atherosclerosis.

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Targeting and clearance of senescent foamy macrophages and senescent endothelial cells by antibody-functionalized mesoporous silica nanoparticles for alleviating aorta atherosclerosis

Cited by 71 publications

References 45 publications

Roles of Macrophages in Atherogenesis

Roles of Macrophages in Atherogenesis

Tetraspanins: Physiology, Colorectal Cancer Development, and Nanomediated Applications

Novel Insights and Current Evidence for Mechanisms of Atherosclerosis: Mitochondrial Dynamics as a Potential Therapeutic Target

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