Chondroprotectives used for the treatment of knee osteoarthritis: A comment

Jargin, Sergei V.

doi:10.1111/1756-185x.14071

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…OA is considered a chronic, low-grade inflammatory disease with a high cytokine content, involving the entire joint rather than the cartilage surface. [15][16][17][18] OA etiopathogenic pathways can include epigenetic modifications, cellular senescence, and an age-related rise in a resulting continuous pro-inflammatory state, defined as "inflammaging". 1,18,19 Synovial fluid contains a variety of pro-inflammatory cytokines, at low concentrations (IL-1β, TNF) or at high concentrations (IL-6).…”

Section: Rheumati C D Is E a S E S And Il-6mentioning

confidence: 99%

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A bond between rheumatic diseases and cancer in the elderly: The interleukin‐6 pathway

et al. 2021

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Interleukin (IL)-6 is a soluble factor secreted by T lymphocytes, involved in antibody generation by B lymphocytes. The IL-6 pathway has risen as a pivotal pathway implicated in immune regulation and dysregulation in various rheumatic diseases.Nonetheless, elevated IL-6 levels can also play a role in cancer. Targeting the IL-6 pathway has led to innovative therapeutic approaches for rheumatic diseases and for COVID-19, particularly in the elderly. Indeed, tocilizumab, an agent targeting IL-6, has recently amassed significant attention as a promising univocal agent for different conditions. In this viewpoint, we sought to recall and describe the common pathway among osteoarthritis, rheumatoid arthritis, and cancer, suggesting that anti-IL-6 may be considered a jack-of-all-trades against inflammaging in the elderly.

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Section: Rheumati C D Is E a S E S And Il-6mentioning

confidence: 99%

“…OA is considered a chronic, low‐grade inflammatory disease with a high cytokine content, involving the entire joint rather than the cartilage surface 15‐18 …”

Section: Rheumatic Diseases and Il‐6mentioning

confidence: 99%

A bond between rheumatic diseases and cancer in the elderly: The interleukin‐6 pathway

et al. 2021

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Bone Marrow Mesenchymal Stem Cells Exert Anti-Inflammatory and Chondrocyte Activity in Rats with Knee Arthritis

Zhang

Qiu

Han

et al. 2022

j biomater tissue eng

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This study investigates whether bone marrow mesenchymal stem cells (BMSCS) exert antiinflammatory and chondrocyte activity in rats with knee arthritis. 36 SD rats were randomly divided into Health group (H group), knee arthritis group (K group), methotrexate group (M group), BMSCs group (B Group), with 9 rats in each group followed by analysis of the levels of TNF-α, IL-6 and IL-1, morphology of knee cartilage by H&E staining, chondrocyte activity by MTT assay, and the expression of NO, ERα and cGMP by Western Blot. H&E staining showed that the surface of knee cartilage in group H was smooth and the morphology of chondrocytes was normal. In group K, bone fissure was formed on articular cartilage surface, and the hyperplasia of deep cells was disorder. The surface of articular cartilage in group B and GROUP M gradually became smooth. Compared with group H, the levels of TNF-α, IL-6 and IL-1 were increased and chondrocytes activity was decreased in group K (P < 0.05) with decreased TNF-α, IL-6 and IL-1 levels and increased chondrocytes activity in group M and B (P < 0.05). The levels of NO, ERα and cGMP in knee cartilage of group K were decreased (P < 0.05) and increased in group M and group B (P < 0.05). Bone marrow mesenchymal cells can down-regulate the levels of IL-6, IL-1 and TNF-α, enhance the activity of chondrocytes, and up-regulate the levels of NO, ERα and cGMP, thus providing a new idea for the treatment of knee arthritis.

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Bone Marrow Mesenchymal Stem Cells Inhibits Inflammation and Promotes Chondrocyte Activity in Knee Arthritis Rats

Huang

Zhu

2023

j biomater tissue eng

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This study intends to assess whether BMSCs inhibits inflammation and promotes chondrocyte activity in knee arthritis. 36 SD rats were randomly assigned into group H, group K, group M and group B. The rat models of knee arthritis were established in Group K, group M and group B. After modeling, BMSCs were infused into rats in group B and methotrexate to rats in group M for 6 weeks followed by analysis of TNF-α, IL-6 and IL-1 levels, morphology of knee cartilage, chondrocyte activity and the expression of NO, ERα and cGMP protein. H&E staining found that the surface of knee cartilage in group H was smooth and the morphology of chondrocytes was normal. In group K, bone fissure was formed on articular cartilage surface, and the hyperplasia of deep cells was disorder. The surface of articular cartilage in group B and M gradually became smooth. Compared to group H, TNF-α, IL-6 and IL-1 levels in group K were increased (P < 0.05); their levels in group M and group B were decreased relative to K group (P < 0.05). Compared to group K, chondrocytes activity in groups H, M and B was increased (P < 0.05). NO, ERα and cGMP levels were decreased in knee cartilage of group K relative to H group (P < 0.05) and increased in group M and group B (P < 0.05). In conclusion, BMSCs can down-regulate IL-6, IL-1 and TNF-α, enhance chondrocytes activity, and up-regulate the levels of NO, ERα and cGMP, thus providing a new idea for treating knee arthritis.

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Chondroprotectives used for the treatment of knee osteoarthritis: A comment

Cited by 3 publications

References 32 publications

A bond between rheumatic diseases and cancer in the elderly: The interleukin‐6 pathway

A bond between rheumatic diseases and cancer in the elderly: The interleukin‐6 pathway

Bone Marrow Mesenchymal Stem Cells Exert Anti-Inflammatory and Chondrocyte Activity in Rats with Knee Arthritis

Bone Marrow Mesenchymal Stem Cells Inhibits Inflammation and Promotes Chondrocyte Activity in Knee Arthritis Rats

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