Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention

Marti, Amelia; Martínez, Isabel; Ojeda‐Rodríguez, Ana; Azcona, Cristina

doi:10.3390/nu13020289

Cited by 13 publications

(4 citation statements)

References 35 publications

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“…( 25 ), including nearly one hundred obese children, confirmed that weight loss was associated with a decrease of chemerin levels and improvement of metabolic syndrome parameters such as insulin, HDL-C and TG. The associations between chemerin and weight loss were reported in several studies in obese pediatric and adult population ( 73 – 77 ). A study by Liu et al.…”

Section: Discussionmentioning

confidence: 83%

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

et al. 2023

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BackgroundVitamin D affects adipogenesis, oxidative stress, inflammation, secretion of adipocytokines, lipid metabolism and thermogenesis. Some researchers postulate that those effects could be exerted by the influence of vitamin D on chemerin levels.Aim of the studyWe aimed to investigate if there is a link between serum 25-hydroksyvitamin D [25(OH)D], chemerin and metabolic profile in overweight and obese children before and after vitamin D supplementation.Material and methodsThe prospective study included 65 overweight and obese children aged 9.08-17.5 years and 26 peers as a control. None of the patients in the study group had received vitamin D within the last twelve months before the study.ResultsThe study group had lower baseline 25(OH)D (p<0.001) and higher chemerin (p<0.001), triglycerides (TG, p<0.001), triglycerides/high density lipoprotein cholesterol (TG/HDL-C, p<0.001), C-reactive protein (CRP, p<0.05), fasting insulin (p<0.001), Homeostasis Model Assessment - Insulin Resistance (HOMA-IR, p<0.001), alanine aminotransferase (ALT, p<0.001) and uric acid (p<0.001) compared to the control group. Baseline vitamin D was related to fasting insulin (R=-0.29, p=0.021), HOMA-IR (R=-0.30, p=0.016), HDL-C (R=0.29, p=0.020) and uric acid (R=-0.28, p=0.037) in the study group. Baseline chemerin was related to insulin at 30’ (R=0.27, p=0.030), 60’ (R=0.27, p=0.033), 90’ (R=0.26, p=0.037) and 120’ (R=0.26, p=0.040) during the oral glucose tolerance test (OGTT) and ALT (R=0.25, p=0.041) in the study group. Correlation between vitamin D and chemerin (R=-0.39, p=0.046) was found only in the control group. After six months of vitamin D supplementation a decrease in CRP (p<0.01), total cholesterol (p<0.05), ALT (p<0.01), glucose at 150’ OGTT (p<0.05) was observed. Moreover, we noticed a tendency for negative association between 25(OH)D and chemerin levels (p=0.085). Multivariable backward linear regression models were build using baseline vitamin D, baseline chemerin and six months chemerin as the dependent variables.ConclusionsOur study confirmed that vitamin D has positive effect on metabolic profile in overweight and obese children. The relationship between vitamin D and chemerin is not clear, nevertheless we have observed a tendency to decrease chemerin concentrations after improving vitamin D status, even without a significant reduction in body fat mass.

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Section: Discussionmentioning

confidence: 83%

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

et al. 2023

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“…Our finding that behavioral weight loss reduces LBP is supported by several lines of evidence. Previous diet- or behavioral-induced weight loss interventions were also found to reduce LBP ( 8 , 14 , 20 ) or intestinal permeability assessed by lactulose:mannitol ratio. ( 13 ) In addition to behavioral weight loss, surgical weight loss has also been shown to reduce LBP, though LBP reduction may depend both on surgical method and timing of LBP measurement post-surgery.…”

Section: Discussionmentioning

confidence: 99%

“…However, weight lost through behavioral intervention or metformin treatment—current first-line treatments for obesity and diabetes, respectively—operate through different physiological mechanisms. ( 19 ) While a behavioral weight loss intervention has been shown to reduce LBP in adolescents with abdominal obesity,( 20 ) there have been no direct comparison between the effects of behavioral weight loss interventions and metformin on LBP in humans.…”

Section: Introductionmentioning

confidence: 99%

A behavioral weight-loss intervention, but not metformin, decreases a marker of gut barrier permeability: results from the SPIRIT randomized trial

et al. 2022

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Background/Objectives: Lipopolysaccharide-binding protein (LBP), a biomarker of gut barrier permeability to lipopolysaccharides, is higher in adults with obesity and type 2 diabetes. Behavioral weight loss and metformin have distinct effects on the gut microbiome, but their impact on gut permeability to lipopolysaccharides is unknown. This study’s objective was to determine the effects of a behavioral weight loss intervention or metformin treatment on plasma LBP. Subjects/Methods: SPIRIT was a randomized trial of adults with overweight or obesity. Participants were randomized to one of three arms: metformin treatment, coach-directed behavioral weight loss on a DASH diet, or self-directed care (control). Of 121 participants, a random subset (n=88) was selected to have LBP measured at baseline, 6-months, and 12-months post intervention. Intervention effects on LBP over time were assessed using generalized estimating equations (GEE). We also examined whether the intervention effects were modified by change in diet and weight. Results: Arms were balanced by sex (83% female), race (51% white), and age (mean 60 years), with no differences in baseline LBP (median 4.23 μg/mL). At 1 year, mean weight change was −3.00% in the metformin arm, −3.02% in the coach-directed behavioral weight-loss arm, and +0.33% in the self-directed (control) arm. The corresponding change in LBP was +1.03, −0.98, +1.03 μg/mL. The behavioral weight-loss reduced LBP compared to self-directed care (β=−0.17, 95% CI: −0.33 to −0.01); no other between-arm comparisons were significant. Participants who reduced dietary fat showed the greatest reductions in 6-month LBP (β=−2.84, 95% CI: −5.17 to −0.50). Conclusions: Despite similar weight loss in the behavioral weight loss and metformin arms, only the behavioral weight loss intervention reduced LBP compared to control. Lifestyle weight loss interventions that promote a DASH diet may be effective at reducing gut barrier permeability to lipopolysaccharides.

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“…Chemerin has been linked to adipogenesis, glucose homeostasis, food intake, and body weight in previous research including gain or loss of function. (Marti, et al, 2021), Female reproductive functions in mammals are influenced by their nutritional status and body composition. The aim of the study was to evaluate weather there is any relation of BMI on chemerin level in serum and follicular fluid with oocyte and Embryo quality in women with infertility candidate for fresh intracytoplasmic sperm injection…”

Section: Introductionmentioning

confidence: 99%

Effect of BMI on chemerin in serum on femals undergoing ICSI

Kadhim¹,

Abbood²

2022

ijhs

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Back ground: Serum chemerin levels are associated with both body fat percentage and BMI, and elevated chemerin levels are associated with metabolic problems and inflammatory shifts. Aim: The aim of this study was to evaluate the effect of BMI in serum and follicular fluid chemerin and Leptin level on patients undergoing ICSI. Patients and methods: This study was performed by participating 44 women undergo ICSI procedure devided in to two groups based on BMI in to non-obese group, theirBMI<30 and obese group there BMI>30 . Both groups are infertile women who attend high institute of infertility diagnosis and assisted reproductive technologies at Al-NAHRAIN university In AL-KADHIMIA city in BAGHDAD. From NOVEMBER 2021 to the end of MAY 2022. Blood sample was drown from each patient at day of oocyte pick up for serum chemerin measurements Also follicular fluid is collected for chemerin and Leptin level. Results: The result in non obese group showed a significant positive correlation was found between Serum chmrin levels, indicating a strong effect size (p< .001). This suggests that as Serum chemerin levels rise, so will FF chemerin.

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Higher Lipopolysaccharide Binding Protein and Chemerin Concentrations Were Associated with Metabolic Syndrome Features in Pediatric Subjects with Abdominal Obesity during a Lifestyle Intervention

Cited by 13 publications

References 35 publications

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

The link between vitamin D, chemerin and metabolic profile in overweight and obese children - preliminary results

A behavioral weight-loss intervention, but not metformin, decreases a marker of gut barrier permeability: results from the SPIRIT randomized trial

Effect of BMI on chemerin in serum on femals undergoing ICSI

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