Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

Akhter, Tansim; Wikström, Gerhard; Larsson, Marita; Bondesson, Ulf; Hedeland, Mikael; Naessén, Tord

doi:10.1016/j.ejogrb.2021.01.016

Cited by 2 publications

(2 citation statements)

References 38 publications

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“…Similarly, asymmetric dimethylarginine (ADMA) also found to be increased in the first trimester at developing early-onset PE [ 39 ]. PTX3 and ADMA might possess mechanistic links between vascular effects in PE and later cardiovascular risk [ 40 ], and the abnormal elevations in both were able to segregate high risk PE patients at early stage [ 41 ].…”

Section: Novel Biochemical Markers With Pe Occurrencementioning

confidence: 99%

Diagnostic biomolecules and combination therapy for pre-eclampsia

Chen

et al. 2022

Reprod Biol Endocrinol

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Pre-eclampsia (PE), associated with placental malperfusion, is the primary reason for maternal and perinatal mortality and morbidity that can cause vascular endothelial injury and multi-organ injury. Despite considerable research efforts, no pharmaceutical has been shown to stop disease progression. If women precisely diagnosed with PE can achieve treatment at early gestation, the maternal and fetal outcomes can be maximally optimized by expectant management. Current diagnostic approaches applying maternal characteristics or biophysical markers, including blood test, urine analysis and biophysical profile, possess limitations in the precise diagnosis of PE. Biochemical factor research associated with PE development has generated ambitious diagnostic targets based on PE pathogenesis and dissecting molecular phenotypes. This review focuses on current developments in biochemical prediction of PE and the corresponding interventions to ameliorate disease progression, aiming to provide references for clinical diagnoses and treatments.

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Section: Novel Biochemical Markers With Pe Occurrencementioning

confidence: 99%

Diagnostic biomolecules and combination therapy for pre-eclampsia

Chen

et al. 2022

Reprod Biol Endocrinol

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“…8 Plasma levels of dimethylarginines are increased in patients with cardiovascular disease 9,10 and preeclampsia. [11][12][13] Holden et al…”

Section: Introductionmentioning

confidence: 99%

Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

Akhter,

Hedeland,

Bergquist

et al. 2023

American J Rep Immunol

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ProblemThe exact biochemical mechanisms that initiate labor are not yet fully understood. Nitric oxide is a potent relaxant of uterine smooth muscles until labor starts, and its precursor is L‐arginine. Asymmetric (ADMA) and symmetric (SDMA) dimethylarginines, are potent NO‐inhibitors. However, arginines (dimethylarginines and L‐arginine) are scarcely studied in relation to labor and childbirth. We aimed to investigate arginines in women with spontaneous (SLVB) and induced (ILVB) term labor with vaginal birth and in women undergoing elective caesarean section (ECS).Method of StudyWomen at gestational week 16–18 were recruited to the population‐based prospective cohort study BASIC at the Uppsala University Hospital, Sweden. Plasma samples taken at start of labor were analyzed for arginines, from SLVB (n = 45), ILVB (n = 45), and ECS (n = 45), using Ultra‐High Performance Liquid Chromatography. Between‐group differences were assessed using Kruskal–Wallis and Mann–Whitney U‐test.ResultsWomen with SLVB and ILVB had higher levels of ADMA (p < .0001), SDMA (p < .05) and lower L‐arginines (p < .01), L‐arginine/ADMA (p < .0001), and L‐arginine/SDMA (p < .01, respectively <.001) compared to ECS. However, ILVB had higher ADMA (p < .0001) and lower L‐arginine (p < .01), L‐arginine/ADMA (p < .0001), and L‐arginine/SDMA (p < .01) compared to SLVB. Results are adjusted for gestational length at birth and cervical dilatation at sampling.ConclusionOur novel findings of higher levels of dimethylarginines in term vaginal births compared to ECS give insights into the biochemical mechanisms of labor. These findings might also serve as a basis for further studies of arginines in complicated pregnancies and labor.

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Dimethylarginines correlate to common carotid artery wall layer dimensions and cardiovascular risk factors in pregnant women with/without preeclampsia: A group comparative study

Cited by 2 publications

References 38 publications

Diagnostic biomolecules and combination therapy for pre-eclampsia

Diagnostic biomolecules and combination therapy for pre-eclampsia

Plasma levels of arginines at term pregnancy in relation to mode of onset of labor and mode of childbirth

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