Aluminum at environmental concentrations affects the sperm quality of the freshwater teleost Astyanax altiparanae: An in vitro study

Assis, Cecília Bertacini de; Branco, Giovana Souza; Moreira, Renata Guimarães; Pinheiro, João Paulo Silva

doi:10.1016/j.cbpc.2021.108983

Cited by 2 publications

(1 citation statement)

References 49 publications

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“…Moreover, spermatozoa are inexpensive to produce and easy to obtain and manipulate in laboratory environments. Displayed in Table 2 [157][158][159][160][161][162][163][164] are several examples of investigations (from 2006 to 2021) using spermatozoa from various phyla as toxicological in vitro models and assessing various reliable endpoints (sperm viability, kinematics and motility, and DNA fragmentation amongst others) for toxicity effects. Studies displayed in Table 2 [157][158][159][160][161][162][163][164] were selected on the basis of including in vitro sperm exposure to various CECs.…”

Section: Role Of Spermatozoa In Toxicology Applicationsmentioning

confidence: 99%

Contaminants of Emerging Concern (CECs) and Male Reproductive Health: Challenging the Future with a Double-Edged Sword

Marcu

Keyser

Petrik

et al. 2023

Toxics

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Approximately 9% of couples are infertile, with half of these cases relating to male factors. While many cases of male infertility are associated with genetic and lifestyle factors, approximately 30% of cases are still idiopathic. Contaminants of emerging concern (CECs) denote substances identified in the environment for the first time or detected at low concentrations during water quality analysis. Since CEC production and use have increased in recent decades, CECs are now ubiquitous in surface and groundwater. CECs are increasingly observed in human tissues, and parallel reports indicate that semen quality is continuously declining, supporting the notion that CECs may play a role in infertility. This narrative review focuses on several CECs (including pesticides and pharmaceuticals) detected in the nearshore marine environment of False Bay, Cape Town, South Africa, and deliberates their potential effects on male fertility and the offspring of exposed parents, as well as the use of spermatozoa in toxicological studies. Collective findings report that chronic in vivo exposure to pesticides, including atrazine, simazine, and chlorpyrifos, is likely to be detrimental to the reproduction of many organisms, as well as to sperm performance in vitro. Similarly, exposure to pharmaceuticals such as diclofenac and naproxen impairs sperm motility both in vivo and in vitro. These contaminants are also likely to play a key role in health and disease in offspring sired by parents exposed to CECs. On the other side of the double-edged sword, we propose that due to its sensitivity to environmental conditions, spermatozoa could be used as a bioindicator in eco- and repro-toxicology studies.

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