Optimization of sulfobutyl-ether-β-cyclodextrin levels in oral formulations to enhance progesterone bioavailability

Enhanced oral bioavailability of koumine by complexation with hydroxypropyl-β-cyclodextrin: preparation, optimization, ex vivo and in vivo characterization

“… 2013 ; Shankar et al. 2021 ). Hence, the present work has not only studied the enhanced water solubility of KME but also its permeability characteristics in everted gut sacs and Caco-2 cell models.…”

Enhancement of the oral bioavailability of isopropoxy benzene guanidine though complexation with hydroxypropyl-β-cyclodextrin

“…In particular, the AUC 0-t of IBG from IBG/HP-β-CD complex (0.75 ± .07 μg/mL·h) increased by 1.56-fold compared with that of the IBG suspension (0.48 ± .06 μg/mL·h) ( p < .01), indicating that the oral bioavailability of IBG was increased by 1.56-fold due to its complexation with HP-β-CD. The incremental bioavailability of IBG may be attributed to the increased solubility of IBG when incorporated in the inclusion complexes, allowing the drug to maintain its soluble form in the gastrointestinal tract (Wang et al, 2007 ; Shankar et al, 2021 ).…”

Dissolution Improvement of Progesterone and Testosterone via Impregnation on Mesoporous Silica Using Supercritical Carbon Dioxide

“…Both TST and PRG are classified as class II according to the Biopharmaceutics Classification System (BCS) and class IIb as per the Developability Classification System (DCS) [70]. Until now, there have been several studies to improve the dissolution of PRG and TST, including the formation of cocrystals [71], cyclodextrin complexation [72][73][74][75][76], polymeric nanoparticles [77,78], micro-/mesoporous materials [79][80][81], and micronisation via rapid expansion of supercritical solution [82]. The supercritical impregnation process is a simple technique with several advantages over conventional methods, including (i) homogenous distribution of active substance within the solid matrix, (ii) environmentally friendly technique for the reduction of waste and the use of toxic organic solvents, (iii) shorter processing times as there is no requirement for an additional drying step, and (iv) any excess drug active can be recycled by avoiding cross-contamination [83].…”