Hemangioblastoma

Gohimont, Nicolas; Tchofo, P. Jissendi; Racu, Marie-Lucie; Entezari, Kim; Salmon, Isabelle; Tondeur, Marianne; Ene, Diana

doi:10.1097/rlu.0000000000003511

Cited by 2 publications

(2 citation statements)

References 8 publications

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“…Patro et al reported a patient with an intracranial hemangiopericytoma in the posterior fossa, which demonstrated intense 68 Ga-PSMA-11 (HBED-CC) uptake and mild 18 F-FDG enhancement [80]. Gohimont et al reported a patient with a history of prostate cancer, who demonstrated 68 Ga-PSMA-HBED-CC uptake in the cerebellum on PET/CT, which was confirmed histopathologically as a hemangioblastoma [81].…”

Section: Other Cns Tumorsmentioning

confidence: 99%

Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors

et al. 2022

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Introduction. Positron emission tomography (PET) imaging with prostate-specific membrane antigen- (PSMA-) binding tracers has been found incidentally to demonstrate uptake in CNS tumors. Following the encouraging findings of several such case reports, there is a growing interest in the potential application of PSMA-targeted PET imaging for diagnostics, theranostics, and monitoring of CNS tumors. This is a systematic literature review on PSMA-binding tracers in CNS tumors. Methods. A PubMed search was conducted, including preclinical and clinical reports. One hundred and twelve records were identified, and after screening, 56 were included in the final report. Results. Tissue studies demonstrated PSMA expression in tumor vascular endothelial cells, without expression in normal brain tissue, though the extent and intensity of staining varied by anti-PSMA antibody and methodology. Most included studies reported on gliomas, which showed strong PSMA ligand uptake and more favorable tumor to background ratios than other PET tracers. There are also case reports demonstrating PSMA ligand uptake in prostate cancer brain metastases, nonprostate cancer brain metastases, and meningiomas. We also review the properties of the various PSMA-binding radiotracers available. Therapeutic and theranostic applications of PSMA-binding tracers have been studied, including labeled alpha- and beta-ray emitting isotopes, as well as PSMA targeting in directing MRI-guided focused ultrasound. Conclusions. There is a potential application for PSMA-targeted PET in neuro-oncology as a combination of diagnostic and therapeutic use, as a theranostic modality for managing CNS tumors. Further research is needed regarding the mechanism(s) of PSMA expression in CNS tumors and its differential performance by tumor type.

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Section: Other Cns Tumorsmentioning

confidence: 99%

Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors

et al. 2022

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“…Hemangiopericytoma (HP) is rare cancer that occurs throughout the body, 1 with overexpression of PSMA, which can be a cause of pitfall in 68 Ga-PSMA-11 PET/CT. 2 The most common location of HP is in the pelvis and lower limbs, much less common in the head and neck region. 3 It is a mesenchymal neoplasm that derives from pericytes surrounding the capillaries.…”

mentioning

confidence: 99%

68Ga–Prostate-Specific Membrane Antigen PET/CT in Imaging of Hemangiopericytoma

Kunikowska

Chrapko

2023

Clin Nucl Med

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Hemangiopericytoma is a mesenchymal neoplasm that derives from pericytes surrounding the capillaries presenting overexpression of PSMA, which can be a source of pitfall in 68Ga-PSMA-11 PET/CT. We reported 2 cases with recurrent hemangiopericytoma grade III with high expression of 68Ga-PSMA-11 in PET/CT. Based on the performed examination, one of them received targeted α-therapy with the IV injection of 225Ac-PSMA-617.

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Hemangioblastoma

Cited by 2 publications

References 8 publications

Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors

Prostate-Specific Membrane Antigen as Target for Neuroimaging of Central Nervous System Tumors

68Ga–Prostate-Specific Membrane Antigen PET/CT in Imaging of Hemangiopericytoma

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