Pluronic F127-tailored lecithin organogel of acyclovir: preclinical evidence of antiviral activity using BALB/c murine model of cutaneous HSV-1 infection

Sharma, Gajanand; Kaur, Bhavneet; Thakur, Kanika; Mahajan, Akanksha; Amarji, Basant; Singh, Mini P.; Katare, Om Prakash

doi:10.1007/s13346-021-00899-5

Cited by 5 publications

(4 citation statements)

References 48 publications

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“…Moreover, their preparation can be easily scaled-up for industrial production. In a recent study, the potential of acyclovir loaded in PLO was investigated on an HSV-1 infection model, demonstrating a major efficacy with respect to a marketed formulation [ 29 ].…”

Section: Introductionmentioning

confidence: 99%

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

et al. 2021

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Infections due to HSV-1 affect many people all over the world. To counteract this pathology, usually characterized by perioral sores or by less frequent serious symptoms including keratitis, synthetic antiviral drugs are employed, such as acyclovir, often resulting in resistant viral strains under long-term use. Many plant-derived compounds, such as mangiferin and quercetin, have demonstrated antiviral potentials. In this study, smart semisolid forms based on phosphatidylcholine and Pluronic were investigated as delivery systems to administer mangiferin on skin and mucosae affected by HSV-1 infection. Particularly, lecithin organogels, Pluronic gel, and Pluronic lecithin organogels were formulated and characterized. After the selection of gel compositions, physical aspects, such as rheological behavior, spreadability, leakage, and adhesion were evaluated, suggesting a scarce suitability of the lecithin organogel for topical administration. Mangiferin was efficiently included in all type of gels. An in vitro study based on the Franz cell enabled us to find evidence of the gel capability to control drug diffusion, especially in the case of Pluronic organogel, while an in vivo study conducted on human volunteers demonstrated the safeness of all of the gels after cutaneous administration. Furthermore, a plaque reduction assay demonstrated the virucidal effect of mangiferin loaded in a Pluronic gel and a Pluronic lecithin organogel against the HSV-1 KOS strain.

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Section: Introductionmentioning

confidence: 99%

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

et al. 2021

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“…The optical microscopy of the microemulsion gel was also performed as a routine characterisation study. The microemulsion gel was diluted to 100 times with distilled water assisted with bath sonication and analysed for particle size as disclosed in the micromeritics and zetapotential section [ 37 ].…”

Section: Methodsmentioning

confidence: 99%

β-Caryophyllene-Loaded Microemulsion-Based Topical Hydrogel: A Promising Carrier to Enhance the Analgesic and Anti-Inflammatory Outcomes

Alharthi,

Ziora,

Mustafa

et al. 2023

Gels

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Musculoskeletal pain and inflammation can vary from localised pain like pain in the shoulders and neck to widespread pain like fibromyalgia, and as per estimates, around 90% of humans have experienced such pain. Oral non-steroidal anti-inflammatory drugs (NSAIDs) are frequently prescribed for such conditions but are associated with concerns like gastric irritation and bleeding. In the present study, a microemulsion-based gel comprising β-caryophyllene, isopropyl myristate, Tween 80, and normal saline was prepared as a topical option for managing topical pain and inflammation. The globules of the microemulsion were below 100 nm with a zetapotential of around −10 mV. The drug entrapment was >87% with a drug loading of >23%. The permeation studies established better skin permeation (20.11 ± 0.96 μg cm−2 h−1) and retention of the drug (4.96 ± 0.02%) from the developed system vis-à-vis the conventional product (9.73 ± 0.35 μg cm−2 h−1; 1.03 ± 0.01%). The dermatokinetic studies established the better pharmacokinetic profile of the bioactive in the epidermis and dermis layers of the skin. The anti-inflammatory potential in carrageenan-induced rat paw oedema was more pronounced than the conventional product (~91% vis-à-vis ~77%), indicating a better pharmacodynamic outcome from the developed system. The nanotechnology-based natural bioactive product with improved efficacy and drug loading can provide a better alternative for the management of musculoskeletal pain.

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“…These topical therapies are available as ointments, creams, powders and aerosols, which are well tolerated without any skin irritation or inflammation. Clotrimazole, econazole, efficonazole, ketoconazole, sertaconazole, and luliconazole, among others, are the drugs of choice to treat cutaneous infections. , Also, oral treatments including griseofulvin, terbinafine, itraconazole, and fluconazole as suspensions or tablets have shown its effectiveness against extensive or severe infections. , However, in the reported work on the pluronic lecithin organogel of acyclovir, the results showed enhanced delivery of acyclovir (ACY) to the deeper targeted site of the skin to treat herpes caused by cutaneous HSV-1 infection. The higher bioavailability and safety observed in the overall performance were attributed due to the synergistic interaction between the properties of excipients and the qualities of the formulation.…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

“… 177 , 178 Also, oral treatments including griseofulvin, terbinafine, itraconazole, and fluconazole as suspensions or tablets have shown its effectiveness against extensive or severe infections. 179 , 180 However, in the reported work on the pluronic lecithin organogel of acyclovir, 157 the results showed enhanced delivery of acyclovir (ACY) to the deeper targeted site of the skin to treat herpes caused by cutaneous HSV-1 infection. The higher bioavailability and safety observed in the overall performance were attributed due to the synergistic interaction between the properties of excipients and the qualities of the formulation.…”

Section: Los: a Sword To Mitigate Skin Diseasesmentioning

confidence: 99%

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

Raut,

Azheruddin,

Kumar

et al. 2024

ACS Omega

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Skin is the largest organ of the human body, as it protects the body from the external environment. Nowadays, skin diseases and skin problems are more common, and millions of people are affected daily. Skin diseases are due to numerous infectious pathogens or inflammatory conditions. The increasing demand for theoretical research and practical applications has led to the rising prominence of gel as a semisolid material. To this end, organogels has been widely explored due to their unique composition, which includes organic solvents and mineral or vegetable oils, among others. Organogels can be described as semisolid systems wherein an organic liquid phase is confined within a three-dimensional framework consisting of self-assembled, cross-linked, or entangled gelator fibers. These gels have the ability to undergo significant expansion and retain substantial amounts of the liquid phase, reaching up to 99% swelling capacity. Furthermore, they respond to a range of physical and chemical stimuli, including temperature, light, pH, and mechanical deformation. Notably, due to their distinctive properties, they have aroused significant interest in a variety of practical applications. Organogels favor the significant encapsulation and enhanced permeation of hydrophobic molecules when compared with hydrogels. Accordingly, organogels are characterized into lecithin organogels, pluronic lecithin organogels, sorbitan monostearate-based organogels, and eudragit organogels, among others, based on the nature of their network and the solvent system. Lecithin organogels contain lecithin (natural and safe as a living cell component) as an organogelator. It acts as a good penetration enhancer. In this review, first we have summarized the fundamental concepts related to the elemental structure of organogels, including their various forms, distinctive features, methods of manufacture, and diverse applications. Nonetheless, this review also sheds light on the delivery of therapeutic molecules entrapped in the lecithin organogel system into deep tissue for the management of skin diseases and provides a synopsis of their clinical applications.

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Pluronic F127-tailored lecithin organogel of acyclovir: preclinical evidence of antiviral activity using BALB/c murine model of cutaneous HSV-1 infection

Cited by 5 publications

References 48 publications

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

Mangiferin-Loaded Smart Gels for HSV-1 Treatment

β-Caryophyllene-Loaded Microemulsion-Based Topical Hydrogel: A Promising Carrier to Enhance the Analgesic and Anti-Inflammatory Outcomes

Lecithin Organogel: A Promising Carrier for the Treatment of Skin Diseases

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