Pregnancy predictors in unexplained infertility after intrauterine insemination

Guan, Huijuan; Tang, Huaiyun; Pan, Linqing; Song, Hang; Tang, Luosheng

doi:10.1016/j.jogoh.2021.102071

Cited by 10 publications

(17 citation statements)

References 29 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Previous studies have indicated that factors such as female age, male age, the timing and frequency of IUI, OS protocol and the post-wash total motile sperm count of semen were related to the clinical pregnancy rate of IUI treatment. [ 1 2 3 4 5 6 ] We explore the effects on the pregnancy outcome of IUI for couples; the results revealed that AMH, duration days of stimulation, OS protocols, EMT and types had significant differences on pregnancy outcome. What's more, there were no significant differences of male factor, including male age and BMI and sperm parameters in each group.…”

Section: Discussionmentioning

confidence: 99%

“…CC, LE and gonadotropin (HMG) are applied for treating ovulatory dysfunction and infertility during IUI cycles. [ 1 6 ] In previous studies, some studies suggested that there was no difference in clinical pregnancy rates between natural cycles and OS cycles;[ 4 16 17 ] however, other studies suggested that OS can improve clinical pregnancy rates than natural cycle. [ 2 18 19 ] In addition, several studies have demonstrated that cycles with HMG are associated with better clinical outcomes than cycles with CC and LE.…”

Section: Discussionmentioning

confidence: 99%

“…The clinical pregnancy rate of IUI is lower than that of ICSI/IVF, many factors were reported associated with the pregnancy rate of IUI, such as female age, treatment protocol, the number of cycles and dominant pre-ovulatory follicles, endometrial thickness (EMT) and smoking. [ 2 3 4 5 ] However, no consistent reports of influencing factors on IUI pregnancy rates have been reported.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Factors influencing the pregnancy outcome of intrauterine insemination and follow-up treatment

et al. 2023

View full text Add to dashboard Cite

A BSTRACT Background: Many factors were reported associated with the pregnancy rate of intrauterine insemination (IUI), which played key role is still debated. Aims: The aim of this study was to explore related clinical pregnancy outcome factor in IUI cycles of non-male factor. Settings and Design: The clinical data of 1232 IUI cycles in 690 couples experiencing infertility who attended the Reproductive Center of Jinling Hospital between July 2015 and November 2021 were retrospectively analysed. Materials and Methods: Female and male age, body mass index (BMI), anti-Müllerian hormone (AMH), male semen parameters before and after wash, endometrial thickness (EMT), artificial insemination timing and ovarian stimulation (OS) protocols were compared between the pregnant group and the non-pregnant group in order to explore any correlation. Statistical Analysis Used: Continuous variables were analysed using independent-samples t -test, and Chi-square test was used for comparison of measurement data between the two groups. P <0.05 was considered statistical significance. Results: There were statistically significant differences in female AMH, EMT and duration of OS between the two groups. The AMH was higher in the pregnant group than in the non-pregnant group ( P < 0.01), the stimulated days was significantly longer ( P < 0.05) and EMT was significantly greater ( P < 0.01) in the pregnant group than in the non-pregnant group. Further analysis showed that when patients with IUI had the following conditions: AMH > 4.5 ng/ml, EMT between 8 and 12 mm and letrozole + human menopausal gonadotropin stimulation with higher clinical pregnancy. However, there were no differences between the pregnant group and the non-pregnant group amongst the female and male age, BMI, hormones on baseline and day of human chorionic gonadotrophin, number of ovulated oocytes, sperm parameters before and after wash, treatment protocols and the timing of IUI ( P > 0.05). Furthermore, there were 240 couples who not pregnant received one or more cycles of in vitro fertilisation/intracytoplasmic sperm injection/ pre-implantation genetic technology treatment, and another 182 couples forgo follow-up treatment. Conclusion: The results of the present study demonstrate that the clinical IUI pregnancy rate is correlated with the factors of female AMH, EMT and OS protocol; more studies and samples are necessary to evaluate whether other factors affect pregnancy rate.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Factors influencing the pregnancy outcome of intrauterine insemination and follow-up treatment

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Although the estimated frequency is between 10% and 15%, due to the social stigma associated with this diagnosis, the true prevalence is likely higher. Between 15% and 37% of couples experiencing infertility have infertility with no known etiology, according to studies [1]. Unexplained infertility is described as a couple's failure to conceive without a definitive explanation after 12 months of trying, or 6 months in females over 35 years old [2].…”

Section: Introductionmentioning

confidence: 99%

Laparoscopic Assessment of the Tubo Ovarian Relationship in Unexplained Infertility

Hadwa

Farahat

Dawood

et al. 2022

JAMMR

View full text Add to dashboard Cite

Background: Unexplained infertility is usually a diagnosis of exclusion. Thus, there must be an absence of an identifiable cause of infertility despite thorough testing and medical investigation demonstrating tubal patency, normal semen parameters, regular ovulation, normal ovarian reserve, and a normal endometrial cavity. Aim: This study aims to assess the prevalence of abnormal tubo-ovarian relationship in women with unexplained infertility by using laparoscopy. Methodology: This was a prospective study which was conducted on 30 couples with unexplained infertility. Evaluation of the tubo ovarian relation with laparoscopy for patient with unexplained infertility who desire spontaneous pregnancy. The main object of the corrective procedure is to get free mobile fallopian tube along with satisfactory tubo-ovaian relation. Results: There were 53.3% of cases had disturbed tubo-ovarian relation, many corrective measures done by laparoscopy, such as adhesiolysis for 30% of cases, excision of cysts for 6.7% of cases, MSH for 16.6% of cases and cauterization of endometriotic patches for 16.6% of cases. In the present study a pregnancy rate of 53,3% (9/16) was seen in cases that showed disturbed tubo ovarian relation and required operative intervention higher than other cases with no detected pathology (4/14) 47.7%. We were able to achieve a higher conception rate among cases owing to operative procedure. Conclusions: The ovum pick up by the fimbrial end of the tube is an essential determining factor for female infertility. The present study confirmed that laparoscopy provided a precise diagnosis of tubo ovarian factor and may switch the initial treatment of unexplained infertility.

show abstract

“…However, many factors affect the success rate of IUI. 3 The female partner's age is a factor that significantly influences the success of IUI. The results showed that the highest pregnancy ratio was in women under 30 years of age.…”

Section: Introductionmentioning

confidence: 99%

Relationship Between the Age of Female Partner and the Intrauterine Insemination Success in Rumah Sakit Ibu dan Anak Puri Bunda Denpasar

Madeleine

Kurniawan²,

Pramesemara³

2022

IABJ

View full text Add to dashboard Cite

Infertility is the inability of couples who have regular sexual intercourse without using protection to achieve pregnancy within one year. The prevalence of infertility was 21.3% in Indonesia. Intrauterine Insemination (IUI) is an assisted reproductive technology chosen by infertile couples to have children. Various factors influence the success of IUI. One factor that influences the success of IUI is the female partner’s age. To determine the relationship between the age of female partners and the success of IUI. This study is descriptive-analytical research with the Cross-Sectional method using secondary data obtained from medical records of patients who underwent IUI procedures from January to March 2020 at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar. Total research subjects are 31 patients with an average age of 32 years. Positive pregnancies in female partners aged 25-35 years are 8 patients (33,3%) and female partners aged 35-40 are 1 patient (14.3%). Most patients had secondary infertility with a duration of 1-3 years. There is no relation between the increasing age of female partners and the decreasing success of IUI at Rumah Sakit Ibu dan Anak Puri Bunda Denpasar (p=0,329). But female partners aged 25-35 years tended to have a positive pregnancy 2,333 times higher than female partners aged 35-40 years (RR=2,333; CI 95%: 0,349-15,612).

show abstract

Pregnancy predictors in unexplained infertility after intrauterine insemination

Cited by 10 publications

References 29 publications

Factors influencing the pregnancy outcome of intrauterine insemination and follow-up treatment

Factors influencing the pregnancy outcome of intrauterine insemination and follow-up treatment

Laparoscopic Assessment of the Tubo Ovarian Relationship in Unexplained Infertility

Relationship Between the Age of Female Partner and the Intrauterine Insemination Success in Rumah Sakit Ibu dan Anak Puri Bunda Denpasar

Contact Info

Product

Resources

About