Inhibition of PARP activity improves therapeutic effect of ARPE-19 transplantation in RCS rats through decreasing photoreceptor death

Gao, Furong; Li, Zongyi; Kang, Ziwei; Liu, Dandan; Ou, Qingjian; Xu, Jingying; Li, Weiye; Tian, Haibin; Jin, Can; Wang, Juan; Zhang, Jieping; Zhang, Jingfa; Lü, Lixia; Xu, Guo‐Tong

doi:10.1016/j.exer.2021.108448

Cited by 1 publication

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“…The laser-induced CNV mice model was generated as described previously [14]. Traumatic CNV in rats was accidentally found when performing subretinal injections [15] in which the needle destroys the integrity of RBCC and then induces the ingrowth of neovessels into subretinal space.…”

Section: Histology Of Cnv In Animal Modelsmentioning

confidence: 99%

Nonhomogenous Hyperreflectivity in the Choriocapillaris Layer on Optical Coherence Tomography Angiography Implies Early Treatment with Anti-VEGF for Central Serous Chorioretinopathy

Zhao

Zhang

2022

Ophthalmic Res

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Introduction: Optical coherence tomography angiography (OCTA) facilitates the detection of the choroidal neovascularization (CNV). This study explored the role of non-homogenous hyperreflectivity implying putative CNV in choriocapillaris layer on OCTA in central serous chorioretinopathy (CSCR). Methods: Thirteen eyes out of 12 patients with CSCR were examined with OCTA. The non-homogenous hyperreflectivity was compared with the histological morphology of experimental CNV. The effect of intravitreal anti-vascular endothelial growth factor (VEGF) was evaluated by analyzing the changes of central macular thickness (CMT) and the height of subretinal fluid (SRF). Results: Comparison of the non-homogenous hyperreflectivity on OCTA with the established CNV in two animal models strongly indicated these signals are putative CNV. During following-up, these non-homogenous hyperreflectivity in CSCR developed into visible CNV on OCTA. Moreover, anti-VEGF treatment was effective to reduce both the SRF and CMT in CSCR with non-homogeneous hyperreflectivity or secondary CNV within 2 months. Conclusion: This study suggested that the non-homogenous hyperreflectivity on OCTA could be served as a diagnostic biomarker for putative CNV in CSCR, implying early treatment with anti-VEGF.

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Section: Histology Of Cnv In Animal Modelsmentioning

confidence: 99%