Drug rash with eosinophilia and systemic symptoms complicated by haemophagocytic lymphohistiocytosis: is screening required?

Drug-Induced Hypersensitivity Syndrome (DIHS)/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis

“…J Eur Acad Dermatol Venereol 2021. J o u r n a l P r e -p r o o f Fulminant type 1 diabetes mellitus 71,72 Fulminant hepatic failure 73,74 Autoimmune hemolytic anemia 52 Renal failure 75 Disseminated intravascular coagulation 76 Myocarditis 68,77 Pneumonitis 78 79 80 Hemophagocytic lymphohistiocytosis (HLH) 81,82 Autoimmune thyroiditis 9 83 78 Long-term sequelae (persistent and/or months to years following acute DIHS/DRESS onset) Arthralgia (rheumatoid arthritis) 9,84 Autoimmune thyroiditis 9 83 78 Vitiligo, 9 83 Alopecia areata 78,83 Myocarditis 85 86 Pneumonitis 78 Systemic lupus erythematosus 87 J o u r n a l P r e -p r o o f 4 for reference of how to use scoring system Each variable parameter was determined at early (days 0-3 after the initial presentation) and later times (2-4 weeks after the initial presentation), and on an as-needed basis. ALT, Alanine aminotransferase; BSA, body surface area; HD, hemodialysis.…”

CME Exam: Drug-Induced Hypersensitivity Syndrome (DIHS)/Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS): Clinical Features and Pathogenesis

“…J Eur Acad Dermatol Venereol 2021. J o u r n a l P r e -p r o o f Fulminant type 1 diabetes mellitus 71,72 Fulminant hepatic failure 73,74 Autoimmune hemolytic anemia 52 Renal failure 75 Disseminated intravascular coagulation 76 Myocarditis 68,77 Pneumonitis 78 79 80 Hemophagocytic lymphohistiocytosis (HLH) 81,82 Autoimmune thyroiditis 9 83 78 Long-term sequelae (persistent and/or months to years following acute DIHS/DRESS onset) Arthralgia (rheumatoid arthritis) 9,84 Autoimmune thyroiditis 9 83 78 Vitiligo, 9 83 Alopecia areata 78,83 Myocarditis 85 86 Pneumonitis 78 Systemic lupus erythematosus 87 J o u r n a l P r e -p r o o f 4 for reference of how to use scoring system Each variable parameter was determined at early (days 0-3 after the initial presentation) and later times (2-4 weeks after the initial presentation), and on an as-needed basis. ALT, Alanine aminotransferase; BSA, body surface area; HD, hemodialysis.…”