Sudden sensorineural hearing loss in patients with vestibular schwannoma

Wasano, Koichiro; Oishi, Naoki; Noguchi, M.; Hentona, Ko; Shinden, Seiichi; Kitama, Tsubasa; Tsuzuki, Nobuyoshi; Kawasaki, Taiji; Hiraga, Yoshihiko; Takei, Yasuhiko; Ogawa, Kaoru

doi:10.1038/s41598-020-80366-2

Cited by 24 publications

(14 citation statements)

References 25 publications

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“…Glucocorticoid shows anti-inflammation, vasospasm relief, local edema alleviation, and other effects. It can remarkably improve inner ear circulation microenvironment and is the first choice for SHL treatment [ 28 ]. Administration methods include systemic administration and local administration.…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Liu

Wang

Xing

2022

BioMed Research International

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The efficacy of tympanum injection and posterior auricular injection in diabetes with sudden hearing loss (SHL) was analyzed. A mobile terminal-based portable pure tone audiometry system and its processing method were established. Based on mobile terminals, a portable pure tone audiometry system including an Android system, pure sound signal generation, pure tone hearing threshold, and client module was established. A masking model and self-adaptive algorithm were used to detect and reduce noise. Besides, the performance of the portable pure tone audiometry system was detected. A total of 46 diabetes patients with SHL diagnosed at the otolaryngology department in BeiChen Hospital between August 2019 and November 2021 were selected as the research objects and randomly divided into the retroauricular group (posterior auricular injection) and the tympanic group (tympanum injection). Each group included 23 cases. All patients received pure tone audiometry (PTA) before and after the treatment. The changes in fasting blood glucose (FPG), 2h postprandial blood glucose (2hPG), and glycosylated hemoglobin (HbA1c) of the patients were monitored before and after the treatment. Besides, tinnitus loudness visual analog scale (VAS), pain VAS, efficacy, and the incidence of adverse reactions of the patients in two groups were compared. The results indicated that the hear threshold error detected by the medical audiometer and a portable pure tone audiometry system was within 2dB. Before the optimization, there was an error of about 10dB between the hear thresholds detected by the self-adaptive algorithm and a medical audiometer. After the treatment, the hear threshold and average PTA of the patients in the retroauricular and the tympanic groups under different frequencies were both reduced compared with those before the treatment ( P < 0.05 ). The tinnitus VAS score in the retroauricular group was decreased more notably than that in tympanic group ( P < 0.01 ), and the pain VAS score was much lower than that in the tympanic group ( P < 0.001 ). The comparison of FPG, 2hPG, HbA1c, the proportions of cured, significantly effective, effective, ineffective patients, and the total effective rate in the patients in the retroauricular and the tympanic groups before and after the treatment all showed no statistical differences ( P > 0.05 ). The incidence of adverse reactions in tympanic group after the treatment was dramatically higher than that in retroauricular group ( P < 0.001 ). The above results demonstrated that posterior auricular injection showed potential application values in the treatment of SHL with diabetes and established a portable pure tone audiometry system as well as its noise processing method.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Liu

Wang

Xing

2022

BioMed Research International

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“…We also analyzed the patterns of hearing loss and the configuration of audiogram was categorized into 7 forms: low-frequency ascending form, U-shaped form, high-frequency descending form, flat form, profound form, dip form, and other forms ( 16 ) (as shown in Supplementary Table 1 ).…”

Section: Methodsmentioning

confidence: 99%

Sudden sensorineural hearing loss as the initial symptom in patients with acoustic neuroma

Song

Wang

et al. 2022

Front. Neurol.

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BackgroundPrevious studies have shown that patients with acoustic neuroma (AN) sometimes present with sudden sensorineural hearing loss (SSNHL) as an initial symptom. The purpose of this research was to investigate the clinical characteristics, diagnosis, and treatment of AN in patients initially diagnosed with SSNHL.Materials and methodsWe reviewed retrospectively the medical records of all patients who were treated as SSNHL initially and were later diagnosed with AN after undergoing magnetic resonance imaging (MRI) at our hospital between 2008 and 2021. Patient demographics, associated complaints (mostly tinnitus and vertigo), the severity of hearing loss, audiogram configurations, auditory brainstem response (ABR), and MRI examination were reviewed and analyzed. In addition, treatment outcomes and management protocols were also included in this study.ResultsA total of 10 (0.7%, 10/1,383) patients presented with SSNHL as the initial symptom and were diagnosed as AN by MRI finally. Of the 10 patients enrolled in this study, four were men and six were women. The average age at the time of diagnosis of SSNHL was 46.2 ± 13.16 years. These patients exhibited varying severity of hearing loss and a variety of audiogram configurations. All patients showed an abnormal ABR. According to the Koos grading standard, there were 5 grade I (intracanalicular [IAC]) tumors, 3 grade II tumors, and 2 grade III tumors. The treatment outcome revealed that 2 patients exhibited recovery of the average hearing of impaired frequency by more than 15 dB, and 6 patients showed no recovery. Furthermore, four patients were referred to undergo surgical treatment after being diagnosed with AN, 1 patient accepted stereotactic radiation therapy, and the remaining 5 patients were on a “wait and scan” strategy.ConclusionThe hearing loss of patients with AN presented with SSNHL may improve with drug treatment. Hearing recovery for SSNHL does not exclude the presence of AN, and all patients initially diagnosed with SSNHL should undergo MRI and ABR to prevent misdiagnosis and delays in potential treatment.

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“…VS, viral infection (e.g. mumps virus), intralabyrinthine hemorrhage and rupture of the labyrinthine window have been reported as causes of SSNHL 7 , 18 – 20 . Previous studies have suggested that risk factors for cerebrovascular and cardiovascular disease can also be considered risk factors for idiopathic SSNHL 21 , 22 .…”

Section: Discussionmentioning

confidence: 99%

“…We conducted a retrospective chart review of patients treated at six tertiary hospitals in Japan as part of the Keio Academical Otolaryngology Research Unit (KAORU) Project 7 . Patients diagnosed with SSNHL and who had undergone a head MRI in the departments of otolaryngology and head and neck surgery were eligible.…”

Section: Methodsmentioning

confidence: 99%

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Severe sudden sensorineural hearing loss related to risk of stroke and atherosclerosis

Tsuzuki

Wasano

Oishi

et al. 2021

Sci Rep

Self Cite

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The cause of idiopathic sudden sensorineural hearing loss (idiopathic SSNHL)—diagnosed after excluding other causes of hearing loss, such as SSNHL associated with vestibular schwannoma (VS)—is unknown. The presumed pathogenesis of idiopathic SSNHL includes circulatory disorders (e.g., cochlear infarction). We tested the hypothesis that patients with SSNHL who are at high stroke risk will have a lower rate of VS compared to those with low stroke risk. The rationale is that the primary cause of SSNHL in patients with high stroke risk might be a circulatory disturbance. We conducted a retrospective study in six hospitals. Our sampling of SSNHL patients included those diagnosed with idiopathic SSNHL and VS-associated SSNHL. SSNHL patients who had a head MRI were stratified by severity of hearing loss and evaluated for differences in the detection rate of VS between the high-scoring CHADS2 (CHADS2-H-), an index of stroke risk, and low-scoring CHADS2 (CHADS2-L-) groups. We identified 916 patients who met the inclusion criteria. For severe hearing loss, the CHADS2-H group had a significantly lower rate of VS than the CHADS2-L group (OR 0 [95% CI 0.00–0.612]; P = 0.007). These results indirectly support the hypothesis that a primary cause of severe idiopathic SSNHL in those at high risk of stroke might be a circulatory disorder.

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Sudden sensorineural hearing loss in patients with vestibular schwannoma

Cited by 24 publications

References 25 publications

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Efficacy of Mesotympanum Injection and Posterior Auricular Injection in Sudden Hearing Loss of Diabetes Patients

Sudden sensorineural hearing loss as the initial symptom in patients with acoustic neuroma

Severe sudden sensorineural hearing loss related to risk of stroke and atherosclerosis

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