Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate

Patra, Srimanta; Mahapatra, Kewal Kumar; Praharaj, Prakash Priyadarshi; Panigrahi, Debasna Pritimanjari; Bhol, Chandra Sekhar; Mishra, Soumya Ranjan; Behera, Bishnu Prasad; Singh, Amruta; Jena, Mrutyunjay; Bhutia, Sujit K.

doi:10.1016/j.mito.2021.01.002

Cited by 11 publications

(3 citation statements)

References 120 publications

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“…Mitochondria are indeed the intracellular site for aerobic respiration and the subsequent synthesis of ATP. Extensive research over the past half a century has revealed numerous biochemical processes involving mitochondria such as protein synthesis, cell metabolism, cell death, calcium signaling, and gene expression in the nucleus that are critically important in the survival of eukaryotes ( Mposhi et al, 2017 ; Vakifahmetoglu-Norberg et al, 2017 ; Patra et al, 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial dynamics involves molecular and mechanical events in motility, fusion and fission

Green

Hossain²,

Eckmann³

2022

Front. Cell Dev. Biol.

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Mitochondria are cell organelles that play pivotal roles in maintaining cell survival, cellular metabolic homeostasis, and cell death. Mitochondria are highly dynamic entities which undergo fusion and fission, and have been shown to be very motile in vivo in neurons and in vitro in multiple cell lines. Fusion and fission are essential for maintaining mitochondrial homeostasis through control of morphology, content exchange, inheritance of mitochondria, maintenance of mitochondrial DNA, and removal of damaged mitochondria by autophagy. Mitochondrial motility occurs through mechanical and molecular mechanisms which translocate mitochondria to sites of high energy demand. Motility also plays an important role in intracellular signaling. Here, we review key features that mediate mitochondrial dynamics and explore methods to advance the study of mitochondrial motility as well as mitochondrial dynamics-related diseases and mitochondrial-targeted therapeutics.

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Section: Introductionmentioning

confidence: 99%

Mitochondrial dynamics involves molecular and mechanical events in motility, fusion and fission

Green

Hossain²,

Eckmann³

2022

Front. Cell Dev. Biol.

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“…This remodeling can impact proliferation, metastasis, or the evasion of apoptotic cell death [21]. Remodeled mitochondrial proteins, in particular, play a role in cancer cell proliferation and the evasion of cell death [22][23][24][25][26][27]. Ca 2+ signalling has been shown to play critical roles in the biology of both normal and malignant oesophageal cells [21].…”

Section: Introductionmentioning

confidence: 99%

“…In the current study, we examined the transcript levels of various components of the Ca 2+ toolkit in OAC samples and in normal oesophageal samples, using data from both The Cancer Genome Atlas (TCGA) and the Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS) consortium [79,80]. We focused on a gene list of Ca 2+ -toolkit components, updated from an original review of these [13], with the addition of known components involved in acid-sensing [10] and those related to mitochondrial function [19,20,[22][23][24][25][26][27].…”

Section: Introductionmentioning

confidence: 99%

Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma

Cutliffe

McKenna

Chandrashekar

et al. 2021

Exploration of Targeted Anti-Tumor Therapy

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Aim: To investigate alterations in transcription of genes, encoding Ca2+ toolkit proteins, in oesophageal adenocarcinoma (OAC) and to assess associations between gene expression, tumor grade, nodal-metastatic stage, and patient survival. Methods: The expression of 275 transcripts, encoding components of the Ca2+ toolkit, was analyzed in two OAC datasets: the Cancer Genome Atlas [via the University of Alabama Cancer (UALCAN) portal] and the oesophageal-cancer, clinical, and molecular stratification [Oesophageal Cancer Clinical and Molecular Stratification (OCCAMS)] dataset. Effects of differential expression of these genes on patient survival were determined using Kaplan-Meier log-rank tests. OAC grade- and metastatic-stage status was investigated for a subset of genes. Adjustment for the multiplicity of testing was made throughout. Results: Of the 275 Ca2+-toolkit genes analyzed, 75 displayed consistent changes in expression between OAC and normal tissue in both datasets. The channel-encoding genes, N-methyl-D-aspartate receptor 2D (GRIN2D), transient receptor potential (TRP) ion channel classical or canonical 4 (TRPC4), and TRP ion channel melastatin 2 (TRPM2) demonstrated the greatest increase in expression in OAC in both datasets. Nine genes were consistently upregulated in both datasets and were also associated with improved survival outcomes. The 6 top-ranking genes for the weighted significance of altered expression and survival outcomes were selected for further analysis: voltage-gated Ca2+ channel subunit α 1D (CACNA1D), voltage-gated Ca2+ channel auxiliary subunit α2 δ4 (CACNA2D4), junctophilin 1 (JPH1), acid-sensing ion channel 4 (ACCN4), TRPM5, and secretory pathway Ca2+ ATPase 2 (ATP2C2). CACNA1D, JPH1, and ATP2C2 were also upregulated in advanced OAC tumor grades and nodal-metastatic stages in both datasets. Conclusions: This study has unveiled alterations of the Ca2+ toolkit in OAC, compared to normal tissue. Such Ca2+ signalling findings are consistent with those from studies on other cancers. Genes that were consistently upregulated in both datasets might represent useful markers for patient diagnosis. Genes that were consistently upregulated, and which were associated with improved survival, might be useful markers for patient outcome. These survival-associated genes may also represent targets for the development of novel chemotherapeutic agents.

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Calreticulin (CALR) promotes ionophore-induced microneme secretion in Toxoplasma gondii

Shan,

Song,

Yang

et al. 2024

Parasitol Res

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Intricate role of mitochondrial calcium signalling in mitochondrial quality control for regulation of cancer cell fate

Cited by 11 publications

References 120 publications

Mitochondrial dynamics involves molecular and mechanical events in motility, fusion and fission

Mitochondrial dynamics involves molecular and mechanical events in motility, fusion and fission

Alterations in the Ca2+ toolkit in oesophageal adenocarcinoma

Calreticulin (CALR) promotes ionophore-induced microneme secretion in Toxoplasma gondii

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