Elevated Serum Concentrations of Remnant Cholesterol Associate with Increased Carotid Intima-Media Thickness in Children and Adolescents

Costanzo, Alessia Di; Perla, Francesco Massimo; D’Erasmo, Laura; Arca, Marcello; Chiesa, Claudio; Pacifico, Lucia

doi:10.1016/j.jpeds.2021.01.019

Cited by 8 publications

(5 citation statements)

References 37 publications

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“…In addition, FMD impairment was found to correlate with Framingham risk score in NAFLD patients [103], enforcing the hypothesis of the role of endothelial dysfunction in the increased cardiovascular risk in NAFLD. Also, the average of IMT, used as a non-invasively marker of endothelial dysfunction and arteriopathy, was significantly increased in NAFLD cases as compared with non NAFLD [104,105]. In a recent meta-analysis, NAFLD patients had more carotid atherosclerosis than controls, with enlarged mean IMT and higher plaque prevalence [106].…”

Section: Endothelial Cell Dysfunctionmentioning

confidence: 99%

Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification

et al. 2022

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Section: Endothelial Cell Dysfunctionmentioning

confidence: 99%

Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification

et al. 2022

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“…Cross-sectional studies showed that elevated fasting RC concentrations were positively associated with mean cIMT and maximum cIMT in 1496 patients with ischemic stroke 13 , and a high RC level indicated a higher risk of intra- and extra-cranial atherosclerosis in 3665 community residents 16 . Even among 767 youth, elevated serum RC levels were associated with increased cIMT 27 . Consistently, coronary artery disease patients with high RC are more likely to have atherosclerotic plaque and plaque rupture 15 , 28 .…”

Section: Discussionmentioning

confidence: 96%

Remnant cholesterol and the risk of carotid plaque in hypertension: results from a community-based screening among old adults in Hangzhou, China

Yu,

Yang,

Shou

et al. 2024

Sci Rep

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Elevated remnant cholesterol (RC) is considered a risk factor for atherosclerotic cardiovascular disease, but the evidence on this association applies to the Chinese population with hypertension is limited. We aimed to explore the association between RC levels and carotid plaque in old adults with hypertension. 8523 hypertensive patients aged ≥ 60 years with serum lipids and carotid ultrasonography data were included in this community-based screening. Fasting RC was calculated as total cholesterol minus high-density lipoprotein cholesterol minus low-density lipoprotein cholesterol (LDLC). The associations of RC levels with carotid plaque risk were evaluated using Logistic regression and restricted cubic spline models. Carotid plaque was screened in 4821 (56.56%) subjects. After multivariable-adjusted, RC was significantly related to carotid plaque [Odd ratio (OR)] = 1.043 per 0.1 mmol/L increase, 95% confidence interval (CI): 1.030–1.056). The highest versus the lowest quartile of RC was 1.928 (1.673–2.223) for carotid plaque. A nonlinear association was found between serum RC levels and the risk of carotid plaque (P for nonlinearity < 0.001). Moreover, an RC > 0.78 mmol/L differentiated patients at a higher risk of carotid plaque compared to those at lower concentrations, regardless of whether LDLC was on target at 2.59 mmol/L. In old adults with hypertension, elevated RC was positively associated with carotid plaque, independent of LDLC and other conventional risk factors.

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“…Fasting RC was not only a risk factor for cardiovascular diseases such as atherosclerosis and myocardial infarction but was also associated with diabetes, kidney disease, and carotid artery intima-media thickness in adolescents ( 22 , 23 , 35 – 37 ). Moreover, it was a useful predictor of postprandial hyperlipidemia ( 38 , 39 ).…”

Section: Discussionmentioning

confidence: 99%

“…This may be due to the differences in lipid levels between adults and children, and RC concentrations in this study were both calculated and measured ( 22 ). In addition, evidence from Di Costanzo et al proved that the prevalence of overweight/obesity and BMI were gradually increased by the RC tertiles, and the RC level was significantly and positively correlated with BMI and waist circumference ( 23 ); besides, Varbo et al found that BMI also increased with nonfasting RC tertile range increase ( 24 ). Moreover, our study and previous studies confirmed that the obese group had higher levels of RC than the normal weight group, both in adults and children ( 13 , 25 , 26 ).…”

Section: Discussionmentioning

confidence: 99%

The relationship of remnant cholesterol and abdominal obesity in children: A cross-sectional study

Tong

Li²,

Liang

et al. 2022

Front. Cardiovasc. Med.

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BackgroundPrevious studies found that remnant cholesterol (RC) is a risk factor for cardiovascular diseases and childhood obesity is associated with cardiometabolic diseases. This study aimed to explore the relationship between RC and abdominal obesity in children.MethodsA total of 5,959 children, aged 6−12 years old, were selected from a cross-sectional study in urban-rural areas of Chongqing, China. RC was calculated by total cholesterol (TC)—high-density lipoprotein (HDL-C) cholesterol—low-density lipoprotein (LDL-C) cholesterol and was divided into four groups by quartiles (Q1–Q4).ResultsCompared to children with the lowest RC (Q1), children with higher RC had significantly higher odds of abdominal obesity (Q2: OR = 1.450, 95% CI: 1.131−1.859, p < 0.05; Q3: OR = 2.127, 95% CI: 1.632−2.772, p < 0.001; Q4: OR = 2.386, 95% CI: 1.819−3.130, p < 0.001). In the stratified analyses by urban-rural areas, the odds ratios were greater in rural areas (Q2: OR = 2.228, 95% CI: 1.572−3.160, p < 0.001; Q3: OR = 3.668, 95% CI: 2.191−6.140, p < 0.001; Q4: OR = 6.490, 95% CI: 2.271−18.551, p < 0.001) than in urban areas (Q2: OR = 1.644, 95% CI: 1.192−2.266, p < 0.05; Q3: OR = 2.266, 95% CI: 1.667−3.082, p < 0.001; Q4: OR = 2.711, 95% CI: 2.005−3.665, p < 0.001).ConclusionsOur study found that RC was positively correlated with abdominal obesity in children, and this association was higher for children living in rural areas.

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Elevated Serum Concentrations of Remnant Cholesterol Associate with Increased Carotid Intima-Media Thickness in Children and Adolescents

Cited by 8 publications

References 37 publications

Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification

Heterogeneity of non-alcoholic fatty liver disease (NAFLD): Implication for cardiovascular risk stratification

Remnant cholesterol and the risk of carotid plaque in hypertension: results from a community-based screening among old adults in Hangzhou, China

The relationship of remnant cholesterol and abdominal obesity in children: A cross-sectional study

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