Comparison of 68Ga-FAPI imaging and cardiac magnetic resonance in detection of myocardial fibrosis in a patient with chronic thromboembolic pulmonary hypertension

Xing, Haiqun; Gong, Juanni; Chen, Bi-Xi; Guo, Xiaojuan; Yang, Yuanhua; Huo, Li; Yang, Min-Fu

doi:10.1007/s12350-020-02517-2

Cited by 11 publications

(4 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nevertheless, myocardial fibrosis cannot be detected by MRI at the early stage of heart failure, and endomyocardial biopsy is invasive. Several case reports revealed that the right heart uptake of 68 Ga-FAPI was observed in patients with idiopathic PAH and chronic thromboembolic pulmonary hypertension (CTEPH) [ 11 , 32 ]. However, it remains unknown whether FAPI-PET/CT can be used to estimate the severity of RV fibrosis or detect RV fibrosis as early as tissue biopsy.…”

Section: Discussionmentioning

confidence: 99%

[18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload

Zeng,

Zhao,

et al. 2023

Respir Res

View full text Add to dashboard Cite

Background Right heart failure (RHF) is a complication of pulmonary hypertension (PH) and increases the mortality independently of the underlying disease. However, the process of RHF development and progression is not fully understood. We aimed to develop effective approaches for early diagnosis and precise evaluation of RHF. Methods Right ventricle (RV) pressure overload was performed via pulmonary artery banding (PAB) surgery in Sprague–Dawley (SD) rats to induce RHF. Echocardiography, right heart catheterization, histological staining, fibroblast activation protein (FAP) immunofluorescence and 18 F-labelled FAP inhibitor-42 ([18 F] -FAPI-42) positron emission tomography/computed tomography (PET/CT) were performed at day 3, week 1, 2, 4 and 8 after PAB. RNA sequencing was performed to explore molecular alterations between PAB and sham group at week 2 and week 4 after PAB respectively. Results RV hemodynamic disorders were aggravated, and RV function was declined based on right heart catheterization and echocardiography at week 2, 4 and 8 after PAB. Progressive cardiac hypertrophy, fibrosis and capillary rarefaction could be observed in RV from 2 to 8 weeks after PAB. RNA sequencing indicated 80 upregulated genes and 43 downregulated genes in the RV at both week 2 and week 4 after PAB; Gene Ontology (GO) analysis revealed that fibrosis as the most significant biological process in the RV under pressure overload. Immunofluorescence indicated that FAP was upregulated in the RV from week 2 to week 8 after PAB; and [18 F] -FAPI-42 PET/CT revealed FAPI uptake was significantly higher in RV at week 2 and further increased at week 4 and 8 after PAB. Conclusion RV function is progressively declined with fibrosis as the most prominent molecular change after pressure overload, and [18 F] -FAPI-42 PET/CT is as sensitive and accurate as histopathology in RV fibrosis evaluation.

show abstract

Section: Discussionmentioning

confidence: 99%

[18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload

Zeng,

Zhao,

et al. 2023

Respir Res

View full text Add to dashboard Cite

show abstract

“…Zhou et al 61 observed that the SUV max of 68Ga‐FAPI PET/CT gradually increased with renal fibrosis grade in patients with mild, moderate, and severe renal fibrosis (3.92 ± 1.50, 5.98 ± 1.6, and 7.67 ± 2.23, respectively; p = 0.039). In addition, FAPI exhibits high uptake in pulmonary fibrosis, idiopathic retroperitoneal fibrosis, IgG4‐related fibrosis, and other diseases 62–64 . However, no information is currently available regarding FAPI imaging characteristics in post‐LT graft fibrosis.…”

Section: Progress In Diagnostic Methods Of Post‐lt Graft Fibrosismentioning

confidence: 99%

“…In addition, FAPI exhibits high uptake in pulmonary fibrosis, idiopathic retroperitoneal fibrosis, IgG4-related fibrosis, and other diseases. [62][63][64] However, no information is currently available regarding FAPI imaging characteristics in post-LT graft fibrosis. Only one study reported patchy or diffusely abnormal concentrations of FAPI in six patients with pathologically confirmed S2-S4 liver fibrosis.…”

Section: Nuclear Medicine Technologymentioning

confidence: 99%

Progress in the diagnosis and treatment of graft fibrosis after liver transplantation

Zhao,

Wang,

Xie

et al. 2024

Portal Hypertension & Cirrhosis

View full text Add to dashboard Cite

Liver transplantation (LT) is considered one of the best treatments for patients with end‐stage liver diseases. However, some patients with no significant clinical manifestations or abnormal laboratory tests still experience graft fibrosis during postoperative follow‐up, which is often recognized by graft histopathology. Graft fibrosis can lead to graft dysfunction, thereby reducing the survival time of the recipient and even requiring re‐transplantation. Currently, noninvasive methods are widely applied in the assessment of hepatic and allograft fibrosis. Although both noninvasive diagnostic models based on laboratory examination indicators and elastography technology that can quantify liver stiffness have some value in the evaluation of fibrosis, the diagnostic accuracy and characteristics of these various methods vary and cannot replace liver biopsy completely. In recent years, some liver‐protective drugs and proprietary Chinese traditional medicines have been proven to delay or reverse chronic liver fibrosis. Nevertheless, their efficacy and safety for LT recipients need to be further verified. This article reviews the diagnosis and treatment of graft fibrosis after LT to provide a reference for improving the overall survival rate of LT recipients.

show abstract

“…Previous researches have revealed positive findings of 68 Ga-FAPI in degenerative osteophytes 6,7 and arthritis 8 . Studies have also shown that 68 Ga-FAPI is a promising method for evaluating cardiac injury/remodeling 9 and myocardial fibrosis 10–12 . However, the description of FAPI uptake in active coronary atherosclerotic plaque is limited 13 .…”

mentioning

confidence: 99%

Increased 68Ga-FAPI Uptake in Active Atherosclerotic Plaque

et al. 2022

View full text Add to dashboard Cite

show abstract

Comparison of 68Ga-FAPI imaging and cardiac magnetic resonance in detection of myocardial fibrosis in a patient with chronic thromboembolic pulmonary hypertension

Cited by 11 publications

References 6 publications

[18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload

[18 F] -FAPI-42 PET/CT assessment of Progressive right ventricle fibrosis under pressure overload

Progress in the diagnosis and treatment of graft fibrosis after liver transplantation

Increased 68Ga-FAPI Uptake in Active Atherosclerotic Plaque

Contact Info

Product

Resources

About