“…The transcriptome profile data presented above revealed the significantly decreased expression of 43 genes associated with T3SS in the ∆ hemK mutant. These genes included 24 genes of the whole hrp / hrc gene cluster coding for the core structural component of T3SS apparatus ( hrpF , XAC0395 , hpaB , hrpE , hrpD6 , hrpD5 , hpaA , hrcS , hrcR , hrcQ , hpaP , hrcV , hrcU , hrpB1 , hrpB2 , hrcJ , hrpB4 , hrpB5 , hrcN , hrpB7 , hrcT , hrcC , hpa1 and hpa2 ), 18 genes encoding for putative T3SS-associated effectors ( hpaF , XAC0419 , avrBs2 , xopR , avrXacE1 , xopX , xopI , xopN / HopAU1 , hrpW , xopK , xopL , XAC3230 , XAC3666 , xopQ / HopQ1 , xopAU , xopAV , xopAP , and xopS ), and hrpX , encoding a transcriptional regulator of virulence ( Figure 6 A, Supplementary Table S1 ) [ 15 , 33 ].…”