Predicting Long-term Survival After Liver Transplantation in Patients With NASH Cirrhosis

Predictors of patient survival following liver transplant in non-alcoholic steatohepatitis: A systematic review and meta-analysis

“…Interestingly, many of these predictors overlap with a tool developed by Karnam and colleagues, which used demographic data from SRTR to identify seven factors impacting 5-year survival in patients undergoing LT for NASH. 36 The factors included in the calculator that overlapped with our findings were: age at LT, functional status, hepatic encephalopathy, ventilatory support at LT, dialysis prior to LT. 14 , 16 , 17 , 15 , 18 , 19 , 20 , 26 , 28 The remaining two predictive variables in their study, serum creatinine and presence of transjugular intrahepatic portosystemic shunts, were not analyzed in our eligible studies. Our study also identified novel variables, likely because our review was not restricted to the SRTR database ( Table 1 ).…”

Predicting the outcome of liver transplantation in patients with non‐alcoholic steatohepatitis cirrhosis: The NASH LT risk‐benefit calculator

“…Recipient comorbidities such as hypertension, chronic obstructive pulmonary disease, diabetes, and history of coronary artery disease were also assessed. We classified functional status into three categories: no assistance (90%–100% of daily activities without significant disease‐related limitations), some assistance (60%–80%), and total assistance (50% or less) 15 . All analyses were conducted using R statistical software (version 4.3) and SAS 9.2 software (Cary, NC, USA).…”

“…These were used for the subsequent analysis and model building. The convergence of the multiple imputation procedure was assessed using graphical methods and relevant convergence diagnostics 15,21 …”

“…Any violation of the proportional hazard assumption was also assessed with appropriate tests, including plots based on Schoenfeld's residuals. Remediating measures were used for variables that violated these assumptions, such as using binary variables for stratifying and using interaction with time for the continuous variables 15 …”

Response to ‘Predictors of mid‐term survival after liver transplantation in patients with NAFLD cirrhosis’

“…Dr Jing and coll. mentioned a study based on the SRTR, an US LT registry, 3 with all the well-known limitations regarding the definition of NAFLD cirrhosis in a registry and a lack of important individual data which can affect prognosis: cardiovascular history, including recent angioplasty, as well as the donor age were not included in the analysis (these two criteria were the major determinants of outcome in our study 2 ). In addition, prognostic factors found in the SRTR study are not very specific to the NAFLD population and the authors do not discuss the link between these factors and the specificity of the population studied.…”