Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors

Guse, Andreas H.; Montoya, Diana C. Gil; Diercks, Björn‐Philipp

doi:10.1016/j.pharmthera.2021.107804

Cited by 13 publications

(12 citation statements)

References 85 publications

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“…Localization in a specific organelle or subset of organelles defines the functional context for many molecules, especially ion and metabolite transporters. For example, there are ion channels and transporters that localize to the plasma membrane or endo/sarcoplasmic reticulum, and even though they might conduct the same ions, they clearly have different impact on cellular function (Butorac et al, 2020; Gandini and Zamponi, 2021; Guse et al, 2021; Lemos et al, 2021; Lopez et al, 2020). Similarly, a large cohort of zinc transporters, responsible for pumping ionic zinc into distinct organelles or in or out of cells, subserve distinct functions, including synaptic modulation (Krall et al, 2021) and co-secretion with milk, in the latter case providing an essential dietary supplement and shaping mammary gland development (McCormick et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter

Kowalczyk

Gbadamosi

Kolor

et al. 2021

Preprint

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Recent advances in genome sequencing have led to the identification of new ion and metabolite transporters, many of which have not been characterized. Due to the variety of subcellular localizations, cargo and transport mechanisms, such characterization is a daunting task, and predictive approaches focused on the functional context of transporters are very much needed. Here we present a case for identifying a transporter localization using evolutionary rate covariation (ERC), a computational approach based on pairwise correlations of amino acid sequence evolutionary rates across the mammalian phylogeny. As a case study, we find that poorly characterized transporter SLC30A9 (ZnT9) uniquely and prominently coevolves with several components of the mitochondrial oxidative phosphorylation chain, suggesting mitochondrial localization. We confirmed this computational finding experimentally using recombinant human SLC30A9. SLC30A9 loss caused zinc mishandling in the mitochondria, suggesting that under normal conditions it acts as a zinc exporter. We therefore propose that ERC can be used to predict the functional context of novel transporters and other poorly characterized proteins.

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Section: Introductionmentioning

confidence: 99%

Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter

Kowalczyk

Gbadamosi

Kolor

et al. 2021

Preprint

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“…Alternatively, the myoinositol can be used to isolate viable sperm cells for ICSI. It represents the most abundant stereoisomer of the inositol class modulating the intracellular concentration of Ca 2+ [ 103 ]. This is synthesized in two steps by two enzymes, myo-1-phosphate synthase and myo-monophosphatase-1, located in high concentration in the testicular mesenchymal tissue [ 104 , 105 ].…”

Section: Advanced Methodsmentioning

confidence: 99%

Sperm Selection for ICSI: Do We Have a Winner?

Baldini

Ferri

Baldini

et al. 2021

Cells

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In assisted reproductive technology (ART), the aim of sperm cells’ preparation is to select competent spermatozoa with the highest fertilization potential and in this context, the intracytoplasmic sperm injection (ICSI) represents the most applied technique for fertilization. This makes the process of identifying the perfect spermatozoa extremely important. A number of methods have now been developed to mimic some of the natural selection processes that exist in the female reproductive tract. Although many studies have been conducted to identify the election technique, many doubts and disagreements still remain. In this review, we will discuss all the sperm cell selection techniques currently available for ICSI, starting from the most basic methodologies and continuing with those techniques suitable for sperm cells with reduced motility. Furthermore, different techniques that exploit some sperm membrane characteristics and the most advanced strategy for sperm selection based on microfluidics, will be examined. Finally, a new sperm selection method based on a micro swim-up directly on the ICSI dish will be analyzed. Eventually, advantages and disadvantages of each technique will be debated, trying to draw reasonable conclusions on their efficacy in order to establish the gold standard method.

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“…The architectural interaction between the Orai-STIM channel complex and IP 3 Rs is a hot issue. 114,115) The positive feedback regulation of Ca 2+ influx via CRAC and/or TRP channels by Ca 2+ -gated K + channels has been reported in a wide range of non-excitable cells. In a chondrocyte-like cell line, histamine-induced Ca 2+ signaling was potentiated by the positive feedback mechanism mainly due to BK channels and SOCE and facilitated extracellular matrix formation and inflammatory prostaglandin production.…”

Section: -2 Physiological Impact Of Ca 2+ -Gated Ion Channels In the Regulation Of Ca 2+ Signaling In Non-excitable Cellsmentioning

confidence: 99%

Reciprocal Relationship between Ca<sup>2+</sup> Signaling and Ca<sup>2+</sup>-Gated Ion Channels as a Potential Target for Drug Discovery

Imaizumi

2022

Biological & Pharmaceutical Bulletin

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Cellular Ca 2 signaling functions as one of the most common second messengers of various signal transduction pathways in cells and mediates a number of physiological roles in a cell-type dependent manner. Ca 2 signaling also regulates more general and fundamental cellular activities, including cell proliferation and apoptosis. Among ion channels, Ca 2 -permeable channels in the plasma membrane as well as endo-and sarcoplasmic reticulum membranes play important roles in Ca 2 signaling by directly contributing to the influx of Ca 2 from extracellular spaces or its release from storage sites, respectively. Furthermore, Ca 2 -gated ion channels in the plasma membrane often crosstalk reciprocally with Ca 2 signals and are central to the regulation of cellular functions. This review focuses on the physiological and pharmacological impact of i) Ca 2 -gated ion channels as an apparatus for the conversion of cellular Ca 2 signals to intercellularly propagative electrical signals and ii) the opposite feedback regulation of Ca 2 signaling by Ca 2 -gated ion channel activities in excitable and non-excitable cells.Key words Ca 2+ signaling; Ca 2+ microdomain; ion channel; Ca 2+ permeable channel; Ca 2+ -activated K + channel; Ca 2+ -activated Cl − channel 2-1. Ca 2+ -Gated Ion Channels The established classification and nomenclature of ion channels need to be referred to those presented by The International Union of Basic and Clinical Pharmacology (IUPHAR) (https://www.guideto pharmacology.org/). 3) One of the practical classifications of ion channels may be that based on gating mechanisms. Table 1 proposes a classification of ion channels on the PM based on their gating mechanisms. RyRs and IP 3 Rs are channels in ER/SR membranes, but are also listed here because of their close involvement in the issues discussed in this review.In this classification, "Ca 2+ -gated ion channels" refer to channels for which an increase in [Ca 2+ ] i is an essential factor for their activation. The Ca 2+ -gated K + channel family consists of three subfamilies classified by channel conduc-

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Mechanisms and functions of calcium microdomains produced by ORAI channels, d-myo-inositol 1,4,5-trisphosphate receptors, or ryanodine receptors

Cited by 13 publications

References 85 publications

Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter

Evolutionary rate covariation identifies SLC30A9 (ZnT9) as a mitochondrial zinc transporter

Sperm Selection for ICSI: Do We Have a Winner?

Reciprocal Relationship between Ca<sup>2+</sup> Signaling and Ca<sup>2+</sup>-Gated Ion Channels as a Potential Target for Drug Discovery

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