Identification of RNA-binding protein SNRPA1 for prognosis in prostate cancer

Abstract

Prostate cancer is one of the deadliest cancers in men. RNA-binding proteins play a critical role in human cancers; however, whether they have a significant effect on the prognosis of prostate cancer has yet to be elucidated. In the present study, we performed a comprehensive analysis of RNA sequencing and clinical data from the Cancer Genome Atlas dataset and obtained differentially expressed RNA-binding proteins between prostate cancer and benign tissues. We constructed a protein-protein interaction network and Cox regression analyses were conducted to identify prognostic hub RNA-binding proteins. SNRPA1 was associated with the highest risk of poor prognosis and was therefore selected for further analysis. SNRPA1 expression was positively correlated with Gleason score and pathological TNM stage in prostate cancer patients. Furthermore, the expression profile of SNRPA1 was validated using the Oncomine, Human Protein Atlas, and Cancer Cell Line Encyclopedia databases. Meanwhile, the prognostic profile of SNRPA1 was successfully verified in GSE70769. Additionally, the results of molecular experiments revealed the proliferative role of SNRPA1 in prostate cancer cells. In summary, our findings evidenced a relationship between RNA-binding proteins and prostate cancer and indicated the prognostic significance of SNRPA1 in prostate cancer.

A new tandem repeat‐enriched lncRNA XLOC_008672 promotes gastric carcinogenesis by regulating G3BP1 expression

“…34 Although we did not find potential target-miRNAs of XLOC_008672 (data not shown), XLOC_008672 was identified to interact directly with RNA-binding protein SNRPA via a series of bioinformatics analysis and molecular biology experiments. Previous studies have elucidated that SNRPA is not only involved in the pre-mRNA splicing process, it can also act as an oncogene in different tumor types, 35,36 and we previously reported that SNRPA promotes tumor cell growth via NGF in GC. 37 The findings in the current work showed another new mechanism in GC development: that SNRPA can be associated with XLOC_008672 and co-regulate the stabilization of G3BP1 mRNA for the first time.…”

Elevated SNRPA1, as a Promising Predictor Reflecting Severe Clinical Outcome via Effecting Tumor Immunity for ccRCC, Is Related to Cell Invasion, Metastasis, and Sunitinib Sensitivity

“…Yuan et al. ( 16 ) also observed the increased value of SNPRA1 in prostate cancer patients; SNRPA1 inhibition also decreased tumor cell migration and colony formation.…”

“…They discovered that the nerve growth factor (NGF) was upregulated with SNRPA overexpression at the mRNA and protein levels, suggesting that NGF is probably a downstream effect in GC. Yuan et al (16) found that the SNRPA1 expression level was positively associated with Gleason score in prostate cancer (PCa). Furthermore, inhibition of SNRPA1 could result in a decrease in PCa cell migration, proliferation, and colony formation.…”

“…Yuan et al. ( 16 ) found that the SNRPA1 expression level was positively associated with Gleason score in prostate cancer (PCa). Furthermore, inhibition of SNRPA1 could result in a decrease in PCa cell migration, proliferation, and colony formation.…”

Identification and verification of prognostic cancer subtype based on multi-omics analysis for kidney renal papillary cell carcinoma

“…miRNA data are characterized by dissociation and can be used for non-invasive diagnosis and dynamic detection of disease (15). Common transcriptome, or mRNA sequencing, is the cheapest and most readily available, and is suitable for use in a wide range of cohort studies to explore general patterns in patient populations (16)(17)(18)(19)(20)(21)(22)(23)(24)(25).…”