“…AS Alport syndrome, CAKUT congenital anomalies of the kidney and urinary tract, CKD Chronic kidney disease, ESKD end stage kidney disease, GKD genetic kidney disease, IQR Interquartile range, FHx family history, FSGS focal segmental glomerulosclerosis, GN glomerulonephritis, PKD polycystic kidney disease, uCKD CKD of uncertain aetiology, TIKD tubulointerstitial kidney disease, Yrs years 1 In total, 677 patients were reviewed in the genetic kidney disease (GKD) clinic, recruited and bio-banked for the evaluation and management of nephropathy. Included in this large cohort, two groups of patients were previously published in the Monogenic Kidney Disease Study [11] and PKD study [23]; these are grouped separately for clarity 2 A positive family history of kidney disease that was reported by the patient (either a 1st-degree relative (parent, child, or sibling) or a 2nd -degree relative (grandparent, aunt, uncle, niece, nephew, or cousin) Non-Cystic GKD: Among 313 families with non-cystic GKD, the diagnostic yield was 27.1%. The diagnostic yield varied within each diagnostic subgroup (Table 2, Supplementary Fig.…”