P50 inhibition defects with psychopathology and cognitive impairment in patients with first-episode drug naïve schizophrenia

Xia, Longlong; Wang, Dongmei; Wei, Gao-Xia; Wang, Jiesi; Zhou, Huixia; Xu, Hang; Tian, Yang; Dai, Qilong; Xiu, Meihong; Chen, Dachun; Wang, Li; Zhang, Xiang Yang

doi:10.1016/j.pnpbp.2021.110246

Cited by 7 publications

(6 citation statements)

References 60 publications

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“…Specifically, we found that patients with FES had abnormal responses to the first stimuli and failure suppression of the S2 response (S1–S2), whereas no impairments were observed in the S2 and S2/S1 ratios. These findings are supported by previous research on sensory gating deficits in Chinese patients with FES ( 5 ). Compared with HC, patients showed lower S1 amplitude, which may be explained by less sensitivity to novel sound stimuli and, therefore, decreased reactivity.…”

Section: Discussionsupporting

confidence: 90%

“…The test P50 wave (S2) was determined as the maximum peak after test stimulation, which was closest to the regulated P50 wave during the incubation period. In the present study, P50 auditory gating components included the S1 amplitude, S2 amplitude, amplitude difference (S1–S2), and gating ratio (S2/S1) ( 5 ). S1 is an individual’s response to normal auditory stimuli, whereas S2 refers to the ability to suppress non-target stimuli in the presence of S1.…”

Section: Methodsmentioning

confidence: 99%

“…Cognitive impairment is one of the core symptoms of schizophrenia that mostly leads to social disabilities ( 1 , 2 ) and determines the prognosis of the disease ( 3 ). As an essential component of human cognitive function, sensory gating refers to the neurological process of filtering out redundant or unnecessary sensory input during information processing ( 4 ), its dysfunction has been frequently observed in patients with schizophrenia ( 5 ). Individuals with schizophrenia show sensory gating deficits, which may be associated with impaired sustained attention ( 6 ), slowed processing speed ( 7 ), and poor working memory performance ( 7 , 8 ).…”

Section: Introductionmentioning

confidence: 99%

“…Some studies suggested that sensory gating deficits might be associated with schizophrenia symptom severity ( 5 ). However, a systematic review reported that cognitive impairment was presented before the onset of first-episode schizophrenia (FES) and persisted even if psychotic symptoms have been normalized ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

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Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia

Yang

Zhang²,

Yang³

et al. 2022

Front. Psychiatry

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ObjectiveOur study aimed to investigate the associations between the serum level of kynurenine pathway (KP) metabolites and P50 auditory gating in non-smoking patients with first-episode schizophrenia (FES).Materials and methodsIn this study, 82 non-smoking patients with FES and 73 healthy controls (HC). P50 auditory gating was measured using a fully functional digital 64-channel EEG system, and the components included S1 amplitude, S2 amplitude, gating ratio (S2/S1), and amplitude difference (S1–S2). Serum levels of kynurenine and kynurenine acid were assessed using a combination of liquid chromatography with tandem mass spectrometry. Psychopathology was assessed by the Positive and Negative Syndrome Scale (PANSS).ResultsThe serum kynurenine (251.46 ± 65.93 ng/ml vs. 320.65 ± 65.89 ng/ml, t = –6.38, p < 0.001), and kynurenine acid levels (5.19 ± 2.22 ng/ml vs. 13.26 ± 4.23 ng/ml, t = –14.73, p < 0.001), S1 amplitude [2.88 (1.79, 3.78) μV vs. 3.08 (2.46, 4.56) μV, Z = –2.17, p = 0.030] and S1–S2 [1.60 (0.63, 2.49) μV vs. 1.92 (1.12, 2.93) μV, Z = –2.23, p = 0.026] in patients with FES were significantly lower than those in HC. The serum kynurenine and kynurenine acid levels were negatively associated with S1–S2 (r = –0.32, p = 0.004 and r = –0.42, p < 0.001; respectively) and positively correlated with S2/S1 ratio (r = 0.34, p = 0.002 and r = 0.35, p = 0.002; respectively) in patients.ConclusionOur findings suggested that neuroactive metabolites of the KP might play an important role in sensory gating deficit in first episode patients with schizophrenia. Furthermore, metabolites of the KP may be a new target for the treatment of cognitive impairments in schizophrenia.

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Section: Discussionsupporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia

Yang

Zhang²,

Yang³

et al. 2022

Front. Psychiatry

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“…investigated a relationship between P50 inhibition and cognitive dysfunction in schizophrenia. The study found that schizophrenia patients had a lower amplitude of S1 and a higher P50 ratio than control subjects but no correlation with cognitive impairment [4]. investigated the auditory sensory gating deficits between Han patients with first-episode, drug naïve (FEDN) schizophrenia and found that patients with FEDN schizophrenia have P50 inhibition defects.…”

Section: Raw Eeg Signalsmentioning

confidence: 99%

A Comprehensive Review on Brain Disease Mapping—The Underlying Technologies and AI Based Techniques for Feature Extraction and Classification Using EEG Signals

Sachadev

Bhatnagar

2021

Studies in Computational Intelligence

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Medical images play an important role in the diagnosis of diseases effectively. Human brain is consisting of millions of neurons which work in proper coordination with one another, and human behavior is an outcome of the response of neurons to internal/external motor or sensory stimuli. These neurons are the carriers of signals from different parts of the human body and the brain. Human cognition studies focus on interpreting either these signals or brain images and there are various technologies which are in use for brain disease studies. Every image or technology generates lot of data in different form which can be modeled using Artificial Intelligence models. The electroencephalogram (EEG) is a recording of the electrical activity of the brain from the scalp. The recorded waveforms reflect the cortical electrical activity. Signal intensity: EEG activity is quite small, measured in microvolts (mV). Delta, Theta, Alpha and Beta are the main frequencies of human EEG waves and EEG electrodes are used to generate EEG plots. In this chapter, authors have tried to capture details on various technologies, techniques, usage of AI models in Brain mapping for disease predictions. This chapter presents a comprehensive account on them and will appeal to researchers in the field of human cognition.

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Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia

Wang¹,

Zeng²,

Yin³

et al. 2023

Asian Journal of Psychiatry

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P50 inhibition defects with psychopathology and cognitive impairment in patients with first-episode drug naïve schizophrenia

Cited by 7 publications

References 60 publications

Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia

Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia

A Comprehensive Review on Brain Disease Mapping—The Underlying Technologies and AI Based Techniques for Feature Extraction and Classification Using EEG Signals

Sensory gating deficits and childhood trauma in the onset of first-episode schizophrenia

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