Natural potential neuroinflammatory inhibitors from Stephania epigaea H.S. Lo

Xiao, Jiangjian; Wang, Yingjie; Yang, Yanqiu; Liu, Jingyu; Chen, Gang; Lin, Bin; Hou, Yue; Li, Ning

doi:10.1016/j.bioorg.2020.104597

Cited by 15 publications

(9 citation statements)

References 46 publications

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“…Modern studies have shown that THP is an active ingredient in some common Chinese medicines, such as Stephania epigaea H.S. Lo [Menispermaceae; Radix stephaniae epigaeae] ( Sun et al, 2020 ; Xiao et al, 2021 ), Corydalis yanhusuo (Y.H.Chou & Chun C.Hsu) W.T.Wang ex Z.Y.Su and C.Y.Wu [Papaveraceae; Corydalis rhizoma] ( Henkes et al, 2011 ), and Stephania yunnanensis H.S. Lo [Menispermaceae; Yunnan Di Bu Rong] ( Ma et al, 2008 ).…”

Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

Meng

Wang

2022

Front. Pharmacol.

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Tetrahydropalmatine (THP), a tetrahydroproberine isoquinoline alkaloid, is widely present in some botanical drugs, such as Stephania epigaea H.S. Lo (Menispermaceae; Radix stephaniae epigaeae), Corydalis yanhusuo (Y.H.Chou & Chun C.Hsu) W.T. Wang ex Z.Y. Su and C.Y. Wu (Papaveraceae; Corydalis rhizoma), and Phellodendron chinense C.K.Schneid (Berberidaceae; Phellodendri chinensis cortex). THP has attracted considerable attention because of its diverse pharmacological activities. In this review, the chemical properties, plant sources, pharmacological activities, pharmacokinetic and toxicological characteristics of THP were systematically summarized for the first time. The results indicated that THP mainly existed in Papaveraceae and Menispermaceae families. Its pharmacological activities include anti-addiction, anti-inflammatory, analgesic, neuroprotective, and antitumor effects. Pharmacokinetic studies showed that THP was inadequately absorbed in the intestine and had rapid clearance and low bioavailability in vivo, as well as self-microemulsifying drug delivery systems, which could increase the absorption level and absorption rate of THP and improve its bioavailability. In addition, THP may have potential cardiac and neurological toxicity, but toxicity studies of THP are limited, especially its long-duration and acute toxicity tests. In summary, THP, as a natural alkaloid, has application prospects and potential development value, which is promising to be a novel drug for the treatment of pain, inflammation, and other related diseases. Further research on its potential target, molecular mechanism, toxicity, and oral utilization should need to be strengthened in the future.

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Section: Introductionmentioning

confidence: 99%

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

Meng

Wang

2022

Front. Pharmacol.

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“… 2015 ), frequently used to treat cough, diarrhea, bellyache, injuries, and malaria (Xiao et al. 2021 ). Previous studies of this species mainly focused on its chemical constituents and medicinal properties (Lv et al.…”

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confidence: 99%

The complete chloroplast genome sequence of the medicinal plant Stephania epigaea H. S. Lo, 1978 (Menispermaceae) from Yunnan, China

Guan

Feng

Fan

2022

Mitochondrial DNA Part B

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Stephania epigaea H. S. Lo, 1978 is a medicinal plant commonly used in southwest China. This study characterized the first complete chloroplast (cp) genome sequence of this species. The complete cp was 157,738 bp in length, containing a large single-copy region (LSC) of 88,460 bp, a small single-copy region (SSC) of 19,778 bp, and a pair of inverted repeat regions (IRs) of 24,750 bp. It encoded 130 genes, including 85 protein-coding genes, 37 tRNA genes, and 8 rRNA genes. The GC content of the complete genome was 36.7%. Phylogenetic analysis of complete cp sequences revealed that S. epigaea was clustered with S. japonica from the Menispermaceae family.

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“…Quantum chemical NMR calculation has become one of the most powerful tools for determining the relative configuration of structures. [ 17 ] To confirm the relative configuration of 1 , theoretical calculation of 13 C NMR combined with DP4+ statistical analysis of 1a — 1d were performed using the GIAO method at the mPW1PW91/6‐311 + G (d,p) level in CD 3 OD. [ 18 ]…”

Section: Resultsmentioning

confidence: 99%

Isosteroidal Alkaloids from Fritillaria verticillata Willd. and Their NMR Spectroscopic Characteristics

et al. 2022

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Chemical investigation of Fritillaria verticillata Willd. led to the isolation of eight novel isosteroidal alkaloids (1-4, 6, 9-11) and four known alkaloids (5, 7-8, 12), including three unprecedented cis-fused D/E (13α, 17α) cevanine alkaloids (1-3), one rarely cis-fused E/F (22α) cevanine alkaloid (6), and one uncommon 5β-jervine-type isosteroidal alkaloid featuring a cis-fused A/B ring moiety (11). In order to establish the structures of 1, the calculated NMR with DP4+ evaluation was applied from the plausible structure candidates. The characteristic proton signals for distinguishing D/E conjunction of cevanine alkaloids were summarized. In addition, some proton and carbon signals α to nitrogen in 6 and 7 are unobservable due to the 14 N nuclear quadrupolar relaxation, based on the NMR experiments in different solvents, calculated NMR method and X-ray technology, their structures were determined. The NMR characteristics of cevanine alkaloids to distinguish orientation of long-pair on nitrogen atom with β-hydroxyl at C-20 were also concluded. The anti-inflammatory effects of compounds 1 and 4 were evaluated in LPS-activated RAW 264.7 macrophages. Compound 4 decreased LPS-induced releases of IL-1β and IL-17α in RAW264.7 cells in a dose-dependent manner. Further mechanistic study revealed that 4 suppressed the phosphorylation of IκBα and p65 subunit to regulate the NF-κB signaling pathway.

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Natural potential neuroinflammatory inhibitors from Stephania epigaea H.S. Lo

Cited by 15 publications

References 46 publications

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

A Comprehensive Review on the Chemical Properties, Plant Sources, Pharmacological Activities, Pharmacokinetic and Toxicological Characteristics of Tetrahydropalmatine

The complete chloroplast genome sequence of the medicinal plant Stephania epigaea H. S. Lo, 1978 (Menispermaceae) from Yunnan, China

Isosteroidal Alkaloids from Fritillaria verticillata Willd. and Their NMR Spectroscopic Characteristics

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