Blood glucose levels should be considered as a new vital sign indicative of prognosis during hospitalization

Kesavadev, Jothydev; Misra, Anoop; Saboo, Banshi; Aravind, SR; Hussain, Akhtar; Czupryniak, Leszek; Raz, Itamar

doi:10.1016/j.dsx.2020.12.032

Cited by 28 publications

(16 citation statements)

References 54 publications

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“…Since diabetes is a major risk factor for the development of mucormycosis, it is important to monitor blood glucose values and aim for maintaining good glycemic control in all patients with COVID-19. This is particularly important given that elevated blood glucose, its variability and inability to maintain it within time-in-range leads to increased morbidity and mortality in COVID-19 [ 18 , 19 ]. In severe COVID-19 treated with corticosteroids, it is challenging to manage hyperglycemia but frequent and judicious use of insulin is useful [ 20 ].…”

Section: Discussionmentioning

confidence: 99%

COVID-19 associated mucormycosis: A Descriptive Multisite Study from India

Gupta

Kesavadev

Krishnan

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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Background and aims Mucormycosis is an invasive fungal infection and carries a significant morbidity and mortality. A number of cases of mucormycosis have been reported in association with COVID-19. In this study, a consortium of clinicians from various parts of India studied clinical profile of COVID-19 associated mucormycosis (CAM) and this analysis is presented here. Methods Investigators from multiple sites in India were involved in this study. Clinical details included the treatment and severity of COVID-19, associated morbidities, as well as the diagnosis, treatment and prognosis of mucormycosis. These data were collected using google spreadsheet at one centre. Descriptive analysis was done. Results There were 115 patients with CAM. Importantly, all patients had received corticosteroids. Diabetes was present in 85.2% of patients and 13.9% of patients had newly detected diabetes. The most common site of involvement was rhino-orbital. Mortality occurred in 25 (21.7%) patients. On logistic regression analysis, CT scan-based score for severity of lung involvement was associated with mortality. Conclusion Universal administration of corticosteroids in our patients is notable. A large majority of patients had diabetes, while mortality was seen in ∼1/5th of patients, lower as compared to recently published data.

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Section: Discussionmentioning

confidence: 99%

COVID-19 associated mucormycosis: A Descriptive Multisite Study from India

Gupta

Kesavadev

Krishnan

et al. 2021

Diabetes & Metabolic Syndrome: Clinical Research & Revi

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“…The addition of bamboo shoot powder to the mice's diet could improve the level of TG (p < 0.05, vs. HFD group). The GLU level can have a substantial effect on morbidity and mortality; for example, even a slight increase in GLU levels can increase the mortality of patients with COVID-19 (Kesavadev et al, 2021). The GLU level was lower in HFBSP mice than in HFD mice (p < 0.01).…”

Section: Biochemical Indicatorsmentioning

confidence: 97%

Using the Major Components (Cellulose, Hemicellulose, and Lignin) of Phyllostachys praecox Bamboo Shoot as Dietary Fiber

Yang

et al. 2021

Front. Bioeng. Biotechnol.

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Bamboo shoots are a renewable and abundant biomass containing cellulose, hemicellulose, and lignin. Although many studies have explored the applications of each of these components in the preparation of biochemicals and biopolymers, few studies have evaluated the utility of these components as a dietary fiber supplement. In this study, a powder consisting of the main components of bamboo shoots (cellulose, hemicellulose, and lignin) was prepared from fresh Phyllostachys praecox shoots and characterized by scanning electron microscopy, infrared spectroscopy, and X-ray diffraction. To evaluate the potential utility of these components as a dietary fiber supplement, we conducted an experiment in which this powder was supplemented in the diet of mice for 7 weeks. The experiment included three diet groups (n = 10/group): a low-fat control diet (LFC), high-fat diet (HFD), and high-fat diet with bamboo shoot powder (HFBSP). Compared with HFD mice, the body weights of LFC and HFBSP mice were lower, indicating that the addition of bamboo shoot powder could reduce the weight gain associated with the HFD. Bamboo shoot powder supplementation could also reduce the levels of triglycerides (TG), blood glucose (GLU), total cholesterol (CHOL), high-density lipoprotein (HDL-C), and low-density lipoprotein (LDL-C) in HFD mice. The fat histology images indicated that obesity was alleviated in HFBSP mice, and the liver histology images indicated that the addition of bamboo shoot powder to the HFD could reduce the risk of fatty liver disease. The addition of bamboo shoot powder to the HFD might also improve the gut microbiota of mice. Thus, the major components of bamboo shoot powder (cellulose, hemicellulose, and lignin) could be used as beneficial natural additives in the food industry.

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“…From Guangdong (China), Zhang et al [ 12 ] showed that FBG at admission accurately predicted 30-day adverse outcomes (acute respiratory distress syndrome, multiple organ dysfunction, ICU admissions, septic shock, or death), irrespective of the presence or absence of pre-existing diabetes. Indeed, it has recently been suggested that blood glucose levels should be considered as a “vital sign” while evaluating hospitalized patients with COVID19 infection [ 13 ].…”

Section: Effects Of Hyperglycemia On Covid19mentioning

confidence: 99%

Diabetes and COVID19: a bidirectional relationship

Unnikrishnan

Misra

2021

Eur J Clin Nutr

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The advent and rapid spread of the coronavirus disease-2019 (COVID19) pandemic across the world has focused attention on the relationship of commonly occurring comorbidities such as diabetes on the course and outcomes of this infection. While diabetes does not seem to be associated with an increased risk of COVID19 infection per se, it has been clearly demonstrated that the presence of hyperglycemia of any degree predisposes to worse outcomes, such as more severe respiratory involvement, ICU admissions, need for mechanical ventilation and mortality. Further, COVID19 infection has been associated with the development of new-onset hyperglycemia and diabetes, and worsening of glycemic control in pre-existing diabetes, due to direct pancreatic damage by the virus, body’s stress response to infection (including cytokine storm) and use of diabetogenic drugs such as corticosteroids in the treatment of severe COVID19. In addition, public health measures taken to flatten the pandemic curve (such as lockdowns) can also adversely impact persons with diabetes by limiting their access to clinical care, healthy diet, and opportunities to exercise. Most antidiabetic medications can continue to be used in patients with mild COVID19 but switching over to insulin is preferred in severe disease.

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Blood glucose levels should be considered as a new vital sign indicative of prognosis during hospitalization

Cited by 28 publications

References 54 publications

COVID-19 associated mucormycosis: A Descriptive Multisite Study from India

COVID-19 associated mucormycosis: A Descriptive Multisite Study from India

Using the Major Components (Cellulose, Hemicellulose, and Lignin) of Phyllostachys praecox Bamboo Shoot as Dietary Fiber

Diabetes and COVID19: a bidirectional relationship

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