Intraocular Injection of HyStem Hydrogel Is Tolerated Well in the Rabbit Eye

Glickman, Randolph D.; Onorato, Michael; Campos, Maria M; O’Boyle, Michael; Singh, Ratnesh; Zarembinski, Thomas I.; Binette, François; Nasonkin, Igor O.

doi:10.1089/jop.2020.0042

Cited by 4 publications

(2 citation statements)

References 36 publications

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“…The last method of hydrogel classification includes their implementation into the body: They might be non-injectable or injectable. Currently, many commercial injectable hydrogels serve as scaffolds for tissue engineering, e.g., EUFLEXXA ® , HyStem ® [89], Corning ® Matrigel ® [90], Biogelx™ [91] and others. The details are presented in Table 1.…”

Section: Hydrogels Dedicated To the Tissue Engineering Applicationsmentioning

confidence: 99%

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

2021

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Injuries of the bone/cartilage and central nervous system are still a serious socio-economic problem. They are an effect of diversified, difficult-to-access tissue structures as well as complex regeneration mechanisms. Currently, commercially available materials partially solve this problem, but they do not fulfill all of the bone/cartilage and neural tissue engineering requirements such as mechanical properties, biochemical cues or adequate biodegradation. There are still many things to do to provide complete restoration of injured tissues. Recent reports in bone/cartilage and neural tissue engineering give high hopes in designing scaffolds for complete tissue regeneration. This review thoroughly discusses the advantages and disadvantages of currently available commercial scaffolds and sheds new light on the designing of novel polymeric scaffolds composed of hydrogels, electrospun nanofibers, or hydrogels loaded with nano-additives.

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Section: Hydrogels Dedicated To the Tissue Engineering Applicationsmentioning

confidence: 99%

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

2021

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“…Another important approach is the thiol modification of the side chains of HyA (Figure 1a) and cross-linking by a di-functional cross-linker (Figure 1b) [31,32]. Hystem ® -a cross-linkable thiol-modified hyaluronic acid (tHyA)-was developed in the USA for biomedical research, and is claimed to be capable of transplanting cells and/or slowly releasing growth factors [33][34][35][36][37]. This material has been followed by several rival clinical products, such as Restylane Lyft ® [33,38], and has not been thoroughly examined as an injection-type bone-forming material [39].…”

Section: Introductionmentioning

confidence: 99%

Bone Formation on Murine Cranial Bone by Injectable Cross-Linked Hyaluronic Acid Containing Nano-Hydroxyapatite and Bone Morphogenetic Protein

Hachinohe

Taira²,

Hoshi³

et al. 2022

Polymers

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New injection-type bone-forming materials are desired in dental implantology. In this study, we added nano-hydroxyapatite (nHAp) and bone morphogenetic protein (BMP) to cross-linkable thiol-modified hyaluronic acid (tHyA) and evaluated its usefulness as an osteoinductive injectable material using an animal model. The sol (ux-tHyA) was changed to a gel (x-tHyA) by mixing with a cross-linker. We prepared two sol–gel (SG) material series, that is, x-tHyA + BMP with and without nHAp (SG I) and x-tHyA + nHAp with and without BMP (SG II). SG I materials in the sol stage were injected into the cranial subcutaneous connective tissues of mice, followed by in vivo gelation, while SG II materials gelled in Teflon rings were surgically placed directly on the cranial bones of rats. The animals were sacrificed 8 weeks after implantation, followed by X-ray analysis and histological examination. The results revealed that bone formation occurred at a high rate (>70%), mainly as ectopic bone in the SG I tests in mouse cranial connective tissues, and largely as bone augmentation in rat cranial bones in the SG II experiments when x-tHyA contained both nHAp and BMP. The prepared x-tHyA + nHAp + BMP SG material can be used as an injection-type osteoinductive bone-forming material. Sub-periosteum injection was expected.

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Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration

Nasonkin¹,

Rizzolo²

2023

The Eye, Volume 4

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Intraocular Injection of HyStem Hydrogel Is Tolerated Well in the Rabbit Eye

Cited by 4 publications

References 36 publications

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

Hydrogel, Electrospun and Composite Materials for Bone/Cartilage and Neural Tissue Engineering

Bone Formation on Murine Cranial Bone by Injectable Cross-Linked Hyaluronic Acid Containing Nano-Hydroxyapatite and Bone Morphogenetic Protein

Stem cell-based organoid cultures as innovative approaches for ocular repair and regeneration

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