Cardiovascular Aging and Longevity

Pietri, P; Stefanadis, Christodoulos

doi:10.1016/j.jacc.2020.11.023

Cited by 38 publications

(7 citation statements)

References 128 publications

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“…The endothelium dysfunction is driven by inflammasome activation and reduced endogenous anti-inflammatory mechanisms in the elderly population. 34 , 35 In addition, inflame-aging activates leukocytes and endothelial and vascular smooth muscle cells, 34 , 35 and aging induces factors V, VII, VIII, and X, increasing the von Willebrand factor. 36 The higher incidence of AT in males reproducing previous evidence 18 suggests differences in hormonal and genetic profiles of both sexes, with female sex hormones producing a favorable immune modulation.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors, Clinical Presentation, Therapeutic Trends, and Outcomes in Arterial Thrombosis Complicating Unvaccinated COVID-19 Patients: A Systematic Review

et al. 2023

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Data on characteristics and outcomes of coronavirus (COVID)-19 patients complicated with arterial thrombosis (AT) are scarce. Therefore, we carried out a systematic review (PRISMA, PROSPERO statements; PubMed, Scopus, and Web of Science) to identify risk factors, clinical presentation, treatment, and outcomes. We included publications from December 2019 to October 2020. Groups: (a) ischemic stroke, (b) thrombotic storm, (c) peripheral vascular thrombosis, (d) myocardial infarction, and (e) left cardiac thrombus or in-transit thrombus (venous system thrombus floating or attaching to the right heart). We considered 131 studies. The most frequent cardiovascular risk factors were: hypertension, diabetes, and dyslipidemia. A high proportion presented with asymptomatic, mild, or moderate COVID-19 ( n = 91, 41.4%). We identified a high percentage of isolated ischemic stroke and thrombotic storm. Groups with higher mortality rate: intracardiac thrombus (1/2, 50.0%), thrombotic storm (18/49, 36.7%), and ischemic stroke (48/131, 36.6%). A small number received thromboprophylaxis. Most patients received antithrombotic treatment. The most frequent bleeding complication was intracranial hemorrhage, primarily with isolated stroke. Overall mortality was 33.6% (74/220). Despite a wide range of COVID-19 severity, a high proportion had AT as a complication of non-severe disease. AT can affect different vascular territories; mortality is associated with stroke, intensive care unit stay, and severe COVID-19.

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Section: Discussionmentioning

confidence: 99%

Risk Factors, Clinical Presentation, Therapeutic Trends, and Outcomes in Arterial Thrombosis Complicating Unvaccinated COVID-19 Patients: A Systematic Review

et al. 2023

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“…The quest to discover the secret of longevity has been on-going for quite some time. It is apparent that life expectancy and cardiovascular aging are closely interrelated, both from a cause-and-effect perspective and from a prevalence point of view [ 2 ]. Based on the most widely accepted theories today, the primary cause of aging is the accretion of ROS and the resulting accumulative oxidative damage, since the efficacy of enzymatic and nonenzymatic antioxidant mechanisms dramatically declines with age [ 18 ].…”

Section: Discussionmentioning

confidence: 99%

“…The hallmarks of aging are postulated to originate from oxidative damages and the resulting disrupted redox imbalance [ 1 ]. Oxidative stress can cause premature apoptosis or senescence by impairing the cellular milieu, and this altered cellular fate serves as a major determinant of lifespan [ 2 ]. Furthermore, it is important to note that changes in cellular redox status and cell death signaling pathways are also causally related to the development of chronic inflammation [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Börzsei

Sebestyén

Szabó

et al. 2022

Oxidative Medicine and Cellular Longevity

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According to a widely accepted theory, oxidative stress is considered to be the number one trigger of aging-associated degenerative processes including cardiovascular diseases. In the context of aging-research, resveratrol receives special attention with its surprising number of health benefits. The aim of our study was to examine the anti-inflammatory and antioxidant effects of this dietary polyphenol in aging rat heart. 20-month-old female and male Wistar rats were divided into control (untreated) and resveratrol-treated groups. Resveratrol was administered at a dose of 0.05 mg/ml for 12 weeks dissolved in drinking water, while the control rats received ad libitum water. Cardiac level of reactive oxygen species (ROS), nuclear factor kappa B (NFκB), tumor necrosis factor alpha (TNF-α), and glutathione (GSH) parameters, as well as the activity of myeloperoxidase (MPO) and heme oxygenase (HO) enzymes were detected. Together with the biochemical measurements, hearts were isolated and used for an exposure of ischemic-reperfusion injury via Langendorff perfusion system. 12 week of resveratrol treatment suppressed the age-related inflammatory pathways including the expression of TNF-α, NFκB, and the activity of MPO while intensified the endogenous antioxidant defenses through the induction of GSH and HO system. Presumably, as a result of these processes, the necrotic area of the heart in response to an acute injury was also significantly reduced in the resveratrol-treated groups. Our findings confirmed that resveratrol has cardioprotective effects at several points by counteracting the aging-associated cellular malfunctions in the heart.

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“…The mechanism of physical activity in promoting health is complex. Physical activity might have a protective effect on enhancing the production of anti-inflammatory markers and inhibiting the production of inflammatory markers, which could help limit the development of many chronic diseases, such as cardiovascular disease and diabetes (37,38), and ultimately reduce mortality and prolong life expectancy (39,40). In addition, physical activity has been evidenced to improve lipid lipoprotein profiles, improve endothelial functions, and reduce bless pressure and coagulation, which is beneficial for cardiovascular health and can reduce mortality risk (41).…”

Section: Discussionmentioning

confidence: 99%

Association of Habitual Physical Activity With the Risk of All-Cause Mortality Among Chinese Adults: A Prospective Cohort Study

Zheng

Huang

et al. 2022

Front. Public Health

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ObjectiveThis study was conducted to evaluate the association of the risk of all-cause mortality with habitual physical activity (HPA) and its different domains among Chinese adults.MethodsA total of 11,994 participants from the Guangzhou Heart Study were followed up until 1 January 2020. Information on HPA, including leisure-time physical activity (LTPA) and commute activity, was collected using a modified Global Physical Activity Questionnaire. Individual cause of death was obtained from the National Death Registry of China. Cox proportional hazards regression model was used to estimate hazard ratio (HR) and 95% confidence interval (CI) after adjustment for covariates.ResultsDuring 37,715 person-years of follow-up, 208 deaths (1.73%) were observed. When compared with the highest with the lowest exposure tertiles, HPA and LTPA were associated with 34% (HR: 0.66, 95% CI: 0.46–0.95) and 30% (HR: 0.70, 95% CI: 0.49–0.99) reduced risk of all-cause mortality after adjustment for covariates. Commute activity was not associated with mortality risk. For the specific component of LTPA, we found that every 1 MET-h/week increment of the housework was associated with a 1% (HR: 0.99, 95% CI: 0.98–0.99) decreased mortality risk, and performing brisk walking/health exercises/Yangko was associated with a 46% reduced mortality risk (HR: 0.54, 95% CI: 0.29–0.99).ConclusionThis study suggests that a higher level of HPA and LTPA was associated with a lower risk of all-cause mortality. Our findings suggest people to perform HPA, especially LTPA, as a strategy for mortality reduction and health promotion.

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Cardiovascular Aging and Longevity

Cited by 38 publications

References 128 publications

Risk Factors, Clinical Presentation, Therapeutic Trends, and Outcomes in Arterial Thrombosis Complicating Unvaccinated COVID-19 Patients: A Systematic Review

Risk Factors, Clinical Presentation, Therapeutic Trends, and Outcomes in Arterial Thrombosis Complicating Unvaccinated COVID-19 Patients: A Systematic Review

Resveratrol as a Promising Polyphenol in Age-Associated Cardiac Alterations

Association of Habitual Physical Activity With the Risk of All-Cause Mortality Among Chinese Adults: A Prospective Cohort Study

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