Sarcopenia is associated with the presence of nonalcoholic fatty liver disease in Zhejiang Province, China: a cross-sectional observational study

Wang, Yuming; Zhu, Ke-Fu; Zhang, Qin; Deng, Dan-Feng; Yang, Yichen; Lu, Wenwen; Xu, Jia; Yang, Yunmei

doi:10.1186/s12877-020-01910-3

Cited by 19 publications

(13 citation statements)

References 29 publications

(34 reference statements)

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“…The relation of sarcopenia with NAFLD and NASH has been subject of recent discussions [ 1 , 5 , 7 , 9 , 16 , 17 , 34 , 35 , 36 ]. This connection is especially interesting in patients with obesity and sarcopenic obesity (SO), as high amounts of visceral fat have been described to be predisposing for NAFLD and NASH [ 13 , 15 ].…”

Section: Discussionmentioning

confidence: 99%

“…The decrease of skeletal muscle mass (sarcopenia) is a widely spread condition leading to multiple inflammatory diseases including non-alcoholic fatty liver disease (NAFLD) and its progressive form non-alcoholic steatohepatitis (NASH) [ 1 , 2 , 3 , 4 , 5 , 6 ]. The link between sarcopenia and NASH might be due to similar pathophysiological mechanisms [ 2 , 4 , 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Association of Body Composition and Sarcopenia with NASH in Obese Patients

Schmitz

Schooren

Kroh

et al. 2021

JCM

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Obese patients often suffer from sarcopenia or sarcopenic obesity (SO) that can trigger inflammatory diseases including non-alcoholic steatohepatitis (NASH). Sarcopenia and SO can be diagnosed through measuring parameters of body composition such as skeletal muscle mass (SMM), skeletal muscle index (SMI) and fat mass (FM) obtained by bioelectrical impedance analysis (BIA). The aim of this study was to assess the relationship of body composition and NASH in patients with obesity. A total of 138 patients with obesity that underwent bariatric surgery were included in this study. BIA was used to estimate body composition. A liver biopsy was taken intraoperatively and histological assessment of NASH was performed. A total of 23 patients (17%) were classified as NASH and 65 patients (47%) met the criteria for borderline NASH. Body mass index (BMI) was significantly higher in patients with NASH compared to borderline NASH and no NASH (56.3 kg/m2 vs. 51.6 kg/m2 vs. 48.6 kg/m2, p = 0.004). Concerning body composition, FM, but also SMM and SMI were significantly higher in patients with NASH (p-values 0.011, 0.005 and 0.006, resp.). Fat mass index (FMI) and weight-adjusted skeletal muscle index (SMI_weight) failed to reach statistical significance (p-values 0.067 and 0.661). In patients with obesity, higher FM were associated with NASH. Contrary to expectations, SMM and SMI were also higher in patients with NASH. Therefore, higher body fat, rather than sarcopenia and SO, might be decisive for development of NASH in patients with obesity.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association of Body Composition and Sarcopenia with NASH in Obese Patients

Schmitz

Schooren

Kroh

et al. 2021

JCM

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“…The association between low androgen levels, reduced physical activity and NAFLD development in the two sexes has been little investigated. However, the strong correlation between sarcopenia and the increased incidence of NAFLD in aging men [ 198 , 454 , 455 ], as well as between high androgen levels and sarcopenia in PCOS women [ 456 ], suggest that low physical activity may further negatively impact on the development and progression of NAFLD in both men and women with altered androgen levels. However, in these physiopathological conditions, reduced physical activity can be a confounding factor, since both, aging men and PCOS women, that are often overweight or obese, move to a less extent than young men or lean women.…”

Section: Nafld and Androgen Signalingmentioning

confidence: 99%

Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology

Torre

2021

Cells

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Non-alcoholic fatty liver disease (NAFLD) is a major health issue worldwide, being frequently associated with obesity, unbalanced dietary regimens, and reduced physical activity. Despite their greater adiposity and reduced physical activity, women show a lower risk of developing NAFLD in comparison to men, likely a consequence of a sex-specific regulation of liver metabolism. In the liver, sex differences in the uptake, synthesis, oxidation, deposition, and mobilization of lipids, as well as in the regulation of inflammation, are associated with differences in NAFLD prevalence and progression between men and women. Given the major role of sex hormones in driving hepatic sexual dimorphism, this review will focus on the role of sex hormones and their signaling in the regulation of hepatic metabolism and in the molecular mechanisms triggering NAFLD development and progression.

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“…The reasons for excluding certain items are shown in the flow chart. Finally, 24 cross-sectional studies12 13 16–38 were included, with a total of 88 609 eligible participants included in the meta-analysis.…”

Section: Resultsmentioning

confidence: 99%

Association between non-alcoholic fatty liver disease and risk of sarcopenia: a systematic review and meta-analysis

Deng,

Ou,

et al. 2024

BMJ Open

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ObjectivesTo determine the association of non-alcoholic fatty liver disease (NAFLD) with the incidence of sarcopenia.DesignSystematic review and meta-analysis of observational clinical studies.Setting and participantsAdults with NAFLD.MethodsDatabases such as PubMed, Embase, Cochrane and Web of Science were searched for eligible studies published from the inception of each database up to 4 April 2023. All cross-sectional studies on the association between NAFLD and sarcopenia were included in this study. The quality of the included studies and risk of bias was assessed using the Agency for Healthcare Research and Quality checklist. STATA V.15.1 software was used for statistical analysis.ResultsOf the 1524 retrieved articles, 24 were included in this review, involving 88 609 participants. Our findings showed that the prevalence of sarcopenia was higher in the NAFLD group than in the control group (pooled OR 1.74, 95% CI 1.39 to 2.17). In a subgroup analysis by region, patients with NAFLD showed an increased risk of sarcopenia (pooled OR 1.97, 95% CI 1.54 to 2.51) in the Asian group, whereas patients with NAFLD had no statistically significant association with the risk of sarcopenia in the American and European groups, with a pooled OR of 1.31 (95% CI 0.71 to 2.40) for the American group and a pooled OR of 0.99 (95% CI 0.21 to 4.69) for the European group. Similar results were observed in the sensitivity analysis, and no evidence of publication bias was observed.Conclusions and implicationsThe current study indicated a significant positive correlation between NAFLD and sarcopenia, which may be affected by regional factors. This study provides the correlation basis for the relationship between NAFLD and sarcopenia and helps to find the quality strategy of sarcopenia targeting NAFLD.

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Sarcopenia is associated with the presence of nonalcoholic fatty liver disease in Zhejiang Province, China: a cross-sectional observational study

Cited by 19 publications

References 29 publications

Association of Body Composition and Sarcopenia with NASH in Obese Patients

Association of Body Composition and Sarcopenia with NASH in Obese Patients

Beyond the X Factor: Relevance of Sex Hormones in NAFLD Pathophysiology

Association between non-alcoholic fatty liver disease and risk of sarcopenia: a systematic review and meta-analysis

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