Anti-NAFLD effect of defatted walnut powder extract in high fat diet-induced C57BL/6 mice by modulating the gut microbiota

Ren, Shumeng; Zhang, Qing-zhu; Chen, Menglin; Jiang, Man; Zhou, Ye; Xu, Xia-jing; Wang, Dongmei; Pan, Yingni; Liu, Xiaoqiu

doi:10.1016/j.jep.2021.113814

Cited by 26 publications

(16 citation statements)

References 35 publications

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“…19 We observed that Helicobacter and Eubacterium_xylanophilum_group had a positive correlation with hepatic disease and liver inflammation that emerged in the pathogenesis of chronic liver diseases. 38 Tian et al indicated the increased abundance of Lachnospiraceae_NK4A136_group in high-fat diet-induced mice, 40 which is in agreement with our results.…”

Section: Papersupporting

confidence: 93%

“…37 Recent abundant evidence has suggested that excessive alcohol drinking can cause the altered composition of intestinal flora and dysbiosis, in return changes in gut microbiota, play a key role in the development of ALD. 5,38 The present results demonstrated that HPGPs decreased the richness and diversity of gut flora, and restored gut dysbacter-Fig. 8 The potential mechanism of HPGPs against ALD based on the gut-liver axis.…”

Section: Food and Function Papermentioning

confidence: 53%

“…19 In addition, Clostridia_UCG-014 is a wellknown intestinal bacterium with an anti-inflammatory effect in mice. 38,41 PGPs could increase the Clostridia_UCG-014 abundance. Taken together, PGPs could enhance the intestinal barrier function and decrease alcohol-induced inflammation by regulating the bacterial components and community abundance, which were associated with increased metabolite SCFA levels.…”

Section: Papermentioning

confidence: 99%

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Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota

et al. 2022

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Section: Papersupporting

confidence: 93%

Section: Food and Function Papermentioning

confidence: 53%

Section: Papermentioning

confidence: 99%

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Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota

et al. 2022

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“…On the other hand, numerous supportive reports proved that the oxidative stress (which occurs when there is an imbalance between the reactive oxygen species (ROS) generation and integrated cellular antioxidant defense systems) induces the increment of lipid peroxidation and protein oxidation, playing an important role in the progression of T2DM and related NAFLD. ,, Furthermore, chronic low-grade systemic inflammation initiated and facilitated by hyperglycemia is the main factor for the well-characterized pathogenesis appearance of NAFLD. , In particular, it is well reported that this kind of inflammation is mediated by NOD-like receptor family pyrin domain-containing 3 (NLRP3) inflammasome. , It is observed that the expression of NLRP3 inflammasome steadily increases in T2DM and NAFLD patients . Inhibition of NLRP3 inflammasome activation could alleviate the inflammation in T2DM-associated NAFLD. , Emerging scientific evidence also indicated that alteration of gut microbiota composition would contribute to the progression of metabolic disorders, such as obesity, T2DM, and NAFLD. , Gut microbiota is mainly modulated by dietary factors; thus, supplement of specific food ingredient or natural products could restore the abnormal situation of gut microbiota to normal, resulting in a beneficial effect on metabolic diseases. − …”

Section: Introductionmentioning

confidence: 99%

Novel Sesquiterpene Glycoside from Loquat Leaf Alleviates Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease by Improving Insulin Resistance, Oxidative Stress, Inflammation, and Gut Microbiota Composition

Chen

Ding

et al. 2021

J. Agric. Food Chem.

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Nonalcoholic fatty liver disease (NAFLD) is strongly associated with type 2 diabetes mellitus (T2DM). Sesquiterpene glycosides from loquat leaf achieved beneficial effects on metabolic syndromes such as NAFLD and diabetes; however, their specific activity and underlying mechanism on T2DM-associated NAFLD have not yet been fully understood. In the present study, we found that sesquiterpene glycoside 3 (SG3), a novel sesquiterpene glycoside isolated from loquat leaf, was able to prevent insulin resistance (IR), oxidative stress, and inflammation. In db/db mice, SG3 administration (25 and 50 mg/kg/day) inhibited obesity, hyperglycemia, and the release of inflammatory cytokines. SG3 (5 and 10 μM) also significantly alleviated hepatic lipid accumulation, oxidative stress, and inflammatory response induced by high glucose combined with oleic acid in HepG2 cells. Western blotting analysis showed that these effects were related to repair the abnormal insulin signaling and inhibit the cytochrome P450 2E1 (CYP2E1) and NOD-like receptor family pyrin domain-containing 3 (NLRP3), both in vivo and in vitro. In addition, SG3 treatment could decrease the ratio of Firmicutes/Bacteroidetes and increase the relative abundance of Lachnospiraceae, Muribaculaceae, and Lactobacillaceae after a high-throughput pyrosequencing of 16S rRNA to observe the changes of related gut microbial composition in db/db mice. These findings proved that SG3 could protect against NAFLD in T2DM by improving IR, oxidative stress, inflammation through regulating insulin signaling and inhibiting CYP2E1/NLRP3 pathways, and remodeling the mouse gut microbiome. It is suggested that SG3 could be considered as a new functional additive for a healthy diet.

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“…Notably, NAFLD is a serious threat to human health, and with delayed treatment, NAFLD will gradually deteriorate and evolve into non-alcoholic steatohepatitis (NASH), cirrhosis, and even liver cancer [ 3 ]. NAFLD occurs for a variety of reasons, such as high-fat diet, sedentary lifestyle, genetically induced hepatic lipid accumulation, and insulin resistance [ 4 ]. Clinical and scientific studies have shown lifestyle changes as the most basic treatment for NAFLD, including proper meal planning and exercise [ 5 , 6 ].…”

Section: Introductionmentioning

confidence: 99%

The Regulatory Effects of Citrus Peel Powder on Liver Metabolites and Gut Flora in Mice with Non-Alcoholic Fatty Liver Disease (NAFLD)

Zhang

Ruan

et al. 2021

Foods

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Gannan navel orange and Jinggang pomelo, belonging to the genus Citrus, are good sources of phenolic compounds, which are mainly concentrated in the peel. These phenolic compounds are considered promising in the prevention and treatment of non-alcoholic fatty liver disease (NAFLD). In order to maximize nutrients retention and bioactivity in the peel, pomelo peel and orange peel were processed using freeze-drying technology and mixed in the ratio (pomelo peel powder 50% and orange peel powder 50%) to make citrus peel powder (CPP). The purpose of this study was to explore new strategies and mechanisms associated with the consumption of CPP to alleviate nonalcoholic fatty liver injury, lipid metabolism disorders, and gut microbiota dysbiosis in obese mice induced by high-fat diet (HFD). The results showed that after 12 weeks of CPP administration, CPP supplementation had a strong inhibitory effect on HFD-induced weight gain, hepatic fat accumulation, dyslipidemia, and the release of pro-inflammatory cytokines. In particular, CPP modulates the composition of the intestinal flora, such as increasing the relative abundance of phylum Firmicutes, genus Faecalibaculum, genus Lactobacillus, genus Dubosiella, and genus Lachnospiraceae_NK4A136_ group and decreasing the relative abundance of phylum Bacteroidota, genus Helicobacter, and genus Bacteroides. These results suggest that CPP has a preventive effect on NAFLD, which can be related to the regulation of intestinal flora.

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Anti-NAFLD effect of defatted walnut powder extract in high fat diet-induced C57BL/6 mice by modulating the gut microbiota

Cited by 26 publications

References 35 publications

Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota

Glucopyranose from Pleurotus geesteranus prevent alcoholic liver diseases by regulating Nrf2/HO-1-TLR4/NF-κB signalling pathways and gut microbiota

Novel Sesquiterpene Glycoside from Loquat Leaf Alleviates Type 2 Diabetes Mellitus Combined with Nonalcoholic Fatty Liver Disease by Improving Insulin Resistance, Oxidative Stress, Inflammation, and Gut Microbiota Composition

The Regulatory Effects of Citrus Peel Powder on Liver Metabolites and Gut Flora in Mice with Non-Alcoholic Fatty Liver Disease (NAFLD)

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