Sesamol Upregulates Death Receptors and Acts as a Chemosensitizer in Solid Ehrlich Carcinoma Model in Mice

Elrazik, Nesma A. Abd; El-Mesery, Mohamed; El-Karef, Amro; Eissa, Laila A.; Gayar, Amal M. El

doi:10.1080/01635581.2020.1871496

Cited by 10 publications

(7 citation statements)

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“…[12][13][14] Sesamol also has antioxidant, antimicrobial, chemoprevention, and antimutagenic properties. [15][16][17] In experimental studies, sesamol is shown to have promising beneficial effects against hepatotoxicity, pancreatitis, heart diseases, diabetes, and neurotoxicity. [18][19][20][21][22] In vitro studies, cytotoxicity and apoptosis-inducing potentials of sesamol have been reported previously against lung adenocarcinoma, human colon cancer cells, human platelets, human hepatoma cells.…”

Section: Introductionmentioning

confidence: 99%

“…[23][24][25][26] In vivo, sesamol administration was shown to act as a chemosensitizer by activating death receptors in cancer models. 15,27 These studies show that sesamol may have beneficial effects against various ailments, and also, it can serve as a cytotoxic agent and chemosensitizer. Therefore, it is reasonable to assume that sesamol could be cytotoxic to OSCC cells.…”

Section: Introductionmentioning

confidence: 99%

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Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

2021

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Sesamol is the main constituent of sesame seed oil and is obtained from Sesamum indicum. Oral squamous cell carcinoma (OSCC) is one of the most common neoplasms affecting the oral cavity. In this study, we investigated the cytotoxic potentials of sesamol on human oral squamous carcinoma (SCC-25) cells. Human oral squamous carcinoma cells were treated with different concentrations (62.5, 125, and 250 μM/mL) of sesamol for 24 h. Cytotoxicity was analyzed by 3- (4, 5- dimethylthiazol -2- yl) -2, 5-diphenyltetrazolium bromide (MTT) assay. Intracellular reactive oxygen species (ROS) expression was investigated by dichloro-dihydro-fluorescein diacetate assay. Apoptosis-related morphology was analyzed by acridine orange/ethidium bromide staining. Caspase-9 expression was analyzed by confocal microscopic double immunofluorescence staining. Mitochondrial apoptosis-related markers are analyzed using qPCR. Sesamol treatment caused a significant cytotoxic effect in OSCC cells. Sesamol-induced cytotoxic effect was associated with intracellular ROS generation. Sesamol treatments induced a significant increase in the early and late apoptotic cells. This treatment also induced caspase-9 expression in OSCC cells. Sesamol treatments caused downregulation of Harvey rat sarcoma viral oncogene homolog (HRAS) expression at protein and gene levels. Sesamol treatment modulates intrinsic apoptotic marker gene expression in OSCC cells. Overall results confirm the anti-cancer potential of sesamol and it seems to be a promising candidate for OSCC.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

2021

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“…Ehrlich model is a cancer that is grown inside the mouse. Its origin is spontaneous breast cancer, and when it spreads inside the mouse, it takes two forms, either ascitic or solid form (Abd Elrazik et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Effect of Some natural products against Ehrlich Ascites Carcinoma in mice: A Review

Haneen Mushtaq Hameed,

Ahmed Flayyih Hasan,

Zainab Haytham Razooki

2024

JFMS

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Cancer is a serious disease and it is one of the main causes of death, and it is considered the second cause, after people who suffer from heart failure. Through the statistics, Breast cancer is one of the most common types of cancer, with a rate of 99% in women and 1% in men. It is very complex, and patients with this type of cancer may face numerous challenges during their treatment period. It was determined that the death rate from cancer had decreased by 1.5%, but it is expected to increase in the future due to an increase in cancer cases (breast, prostate). Ehrlich model is a cancer that grows inside a mouse. Its origin is spontaneous mammary carcinoma, and when it spreads within the mouse, it takes two forms, either ascitic or solid. Ehrlich's ascites carcinoma is a spontaneous breast cancer that has a very high importance in scientific research. It is undifferentiated and has a short life. This type of cancer was used for the first time in 1932, when it was used inside the mouse in the abdomen, and a type of fluid was obtained for this called ( Ehrlich's ascites) due to the liquid substance on which cancer cells depend and consider it food and a means for rapid tumor growth, EAC deficiency causes anemia and thus causes a decrease in red blood cells or hemoglobin, EAC causes an increase in urea and a decrease in creatinine, and EAC causes an increase in liver enzymes and a decrease in total protein.Natural products are the only and most effective products that lead to the development of drugs, especially anti-cancer drugs and anti-inflammatories. Through studies, it has become clear that natural products are a source of drugs.

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“…Natural compounds have been interesting spots for research as effective therapies for different human diseases and, therefore, several research studies have been directed by us and others to explore the biological effects of several natural compounds (Abd Elrazik et al, 2021;Bashir et al, 2020;El-Hawary et al, 2019;El-Mesery et al, 2020;Eraky et al, 2018;Helmy et al, 2019). Black seed oil (BSO) is one of the commonly available natural extracts.…”

Section: Introductionmentioning

confidence: 99%

Amelioration effect of black seed oil against high‐fat diet‐induced obesity in rats through Nrf2/HO‐1 pathway

et al. 2021

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Obesity is a chronic inflammatory disease that represents a risk factor for number of diseases including diabetes, steatohepatitis, and cancer. Using safe natural compounds to ameliorate obesity and its related metabolic syndrome is an interesting spot for research. We investigated the regulatory role and the underlying mechanism of black seed oil (BSO) on high-fat diet (HFD)-induced obesity in rats. The study included two models: the first one aimed to study the prophylactic effect of BSO (BSO administration for 10 weeks along with HFD) while the second one aimed to study the treatment role of BSO (BSO administration starting from the 10th week for 4 weeks along with HFD). BSO significantly decreased insulin resistance and body weight characteristics in both models. It also normalized lipid profile. Moreover, histopathological examination confirmed these results as BSO significantly decreased adipocyte size and hepatic lipid deposition. Besides, BSO alleviated HFD-induced oxidative stress as indicated by significant increase in the total antioxidant capacity and significant decrease in liver malondialdehyde. Moreover, BSO decreased significantly liver gluconeogenic enzymes mRNA expressions (phosphoenolpyruvate carboxykinase and glucose-6-phosphatase) and increased significantly heme oxygenase-1 (HO-1), nuclear factor erythroid-2-related factor-2 (Nrf2) and insulin receptor mRNA expressions. In conclusion, BSO represents a natural therapy that has the ability to prevent and treat HFD-induced obesity in rats that may be mediated through Nrf2/ HO-1 pathway's activation and insulin receptor expression's increase. To our best knowledge, this study represents a novel study that investigates the regulatory role of BSO on Nrf2 pathway in preventing and treating HFD-induced obesity. Practical applicationsBlack seed oil is a natural available safe supplement, thus it can be used for prevention from obesity and even treatment of obesity and obesity related complications. Introducing of black seed oil in the treatment regimen of obese patients may be promising. K E Y W O R D Sblack seed oil, heme oxygenase-1, high-fat diet, nuclear factor erythroid-2-related factor-2, obesity cines might be less effective for individuals with obesity (Popkin et al., 2020). | CON CLUS IONThese results stated that BSO has a crucial role in the prevention and treatment of insulin resistance, obesity, dyslipidemia, adipocyte enlargement, hepatic steatosis, oxidative stress, inflammation, and gluconeogenesis induced by HFD, through activation of Nrf2/HO-1 pathway (Figure 7). These findings may support the potential use of BSO in the prevention and treatment of metabolic syndrome.

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Sesamol Upregulates Death Receptors and Acts as a Chemosensitizer in Solid Ehrlich Carcinoma Model in Mice

Cited by 10 publications

References 70 publications

Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

Sesamol induces cytotoxicity via mitochondrial apoptosis in SCC-25 cells

Effect of Some natural products against Ehrlich Ascites Carcinoma in mice: A Review

Amelioration effect of black seed oil against high‐fat diet‐induced obesity in rats through Nrf2/HO‐1 pathway

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