Propofol rather than Isoflurane Accelerates the Interstitial Fluid Drainage in the Deep Rat Brain

Zhao, Guomei; Han, Hongbin; Wang, Wei; Jia, Kaiying

doi:10.7150/ijms.54320

Cited by 3 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anesthetized rats were fixed in a stereotaxic apparatus (Lab Standard Stereotaxic-Single; Stoelting Co., Wood Dale, IL, USA) with either of the following: 1) citicoline (5 µL, 25 mM) (CPu-25 group); 2) citicoline (5 µL, 40 mM) (CPu-40 group); 3) citicoline (5 µL, 50 mM) (CPu-50 group); 4) citicoline (5 µL, 60 mM) (CPu-60 group); 5) citicoline (5 µL, 75 mM) (CPu-75 group); or 6) 5 μL saline (control group) injected into the right CPu (AP: 0mm, L: -2.8 mm, V: -5.8 mm) as previously described [6,9,10]. In the IP group, anesthetized rats received an IP injection of 2 g/kg citicoline.…”

Section: Experimental Groups and Permanent Mca Occlusion In Ratsmentioning

confidence: 99%

Efficacy of Citicoline Delivered via Brain Extracellular Space against Experimental Acute Ischemic Stroke in Rats

Zhao,

Chen,

Yan

et al. 2024

Int. J. Med. Sci.

Self Cite

View full text Add to dashboard Cite

Objective: Citicoline can be used to reduce acute ischemic stroke injury via venous infusion, however, its protective effects in the brain extracellular space remain largely unknown. Herein, we investigated the brain protective effects of citicoline administered via the brain extracellular space and sought precise effective dosage range that can protect against ischemic injury after experimental ischemic stroke in rats. Methods : Fifty-six Sprague-Dawley rats were randomly divided into control, intraperitoneal (IP), caudate-putamen (CPu)-25, CPu-40, CPu-50, CPu-60 and CPu-75 groups based on the infusion site and concentration of citicoline. Two hours after the administration of citicoline, the rats were subjected to a permanent middle cerebral artery occlusion to mimic acute ischemic stroke. Then, the brain infarct volume in rats after stroke was measured and their neurological deficiency was evaluated to explain the protective effects and effective dosage range of citicoline. Results: Compared to the control and IP groups, brain infarct volume of rats in CPu-40, CPu-50, and CPu-60 groups is significant smaller. Furthermore, the brain infarct volume of rats in CPu-50 is the least. Conclusions: Here, we showed that citicoline can decrease the brain infarct volume, thus protecting the brain from acute ischemic stroke injury. We also found that the appropriate effective citicoline dose delivered via the brain extracellular space is 50 mM. Our study provides novel insights into the precise treatment of acute ischemic stroke by citicoline via the brain extracellular space, further guiding the treatment of brain disease.

show abstract

Section: Experimental Groups and Permanent Mca Occlusion In Ratsmentioning

confidence: 99%

Efficacy of Citicoline Delivered via Brain Extracellular Space against Experimental Acute Ischemic Stroke in Rats

Zhao,

Chen,

Yan

et al. 2024

Int. J. Med. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases

Yong,

Cai,

Lin

et al. 2024

Med-X

View full text Add to dashboard Cite

Cells in the brain are surrounded by extracellular space (ECS), which forms porous nets and interconnected routes for molecule transportation. Our view of brain ECS has changed from a largely static compartment to dynamic and diverse structures that actively regulate neural activity and brain states. Emerging evidence supports that dysregulation of brain ECS contributes to the pathogenesis and development of many neurological disorders, highlighting the importance of therapeutic modulation of brain ECS function. Here, we aim to provide an overview of the regulation and dysfunction of ECS in healthy and pathological brains, as well as advanced tools to investigate properties of brain ECS. This review emphasizes modulation methods to manipulate ECS with implications to restore their function in brain diseases. Graphical Abstract

show abstract

Could dexmedetomidine be repurposed as a glymphatic enhancer?

Persson

Uusalo

Nedergaard

et al. 2022

Trends in Pharmacological Sciences

View full text Add to dashboard Cite

Propofol rather than Isoflurane Accelerates the Interstitial Fluid Drainage in the Deep Rat Brain

Cited by 3 publications

References 33 publications

Efficacy of Citicoline Delivered via Brain Extracellular Space against Experimental Acute Ischemic Stroke in Rats

Efficacy of Citicoline Delivered via Brain Extracellular Space against Experimental Acute Ischemic Stroke in Rats

Advancement in modulation of brain extracellular space and unlocking its potential for intervention of neurological diseases

Could dexmedetomidine be repurposed as a glymphatic enhancer?

Contact Info

Product

Resources

About