Correspondence to ‘Bacterial citrullinated epitopes generated by<i>Porphyromonas gingivalis</i>infection—a missing link for ACPA production’

Sheng‐Kai, Kevin; Chiang, Cheng‐Yang; Chen, Yiwen; Wang, Li‐Tzu

doi:10.1136/annrheumdis-2020-219255

Cited by 28 publications

(37 citation statements)

References 14 publications

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“…Particularly, although the short‐term consequences of tonsillectomy are well documented and managed, its long‐term side effects have not been fully investigated. Recently, there were shreds of evidence showing that the removal of tonsils could bring about not only respiratory infections 8 or acute myocardial infarction, 24 but also IBS 9,10 and immune‐related diseases, such as autoimmune diseases 15,25 . For instance, a cohort study demonstrated that individuals who underwent tonsillectomy had a 1.71‐fold higher risk of developing deep neck infections; 4 moreover, patients receiving tonsillectomy were subsequently diagnosed with autoimmune diseases at an increased standardized incidence ratio of 1.34 25 .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, there were shreds of evidence showing that the removal of tonsils could bring about not only respiratory infections 8 or acute myocardial infarction, 24 but also IBS 9,10 and immunerelated diseases, such as autoimmune diseases. 15,25 For instance, a cohort study demonstrated that individuals who underwent tonsillectomy had a 1.71-fold higher risk of developing deep neck infections; 4 moreover, patients receiving tonsillectomy were subsequently diagnosed with autoimmune diseases at an increased standardized incidence ratio of 1.34. 25 Likewise, a retrospective study on 115,214 children provided that children aged between 0 and 9 years experienced higher rates of respiratory and airway complications, 26 similar findings were seen in other cohort studies showing that metropolitan children, aged between 5 and 9 years, who had undergone tonsillectomy demonstrated higher incidence of subsequent asthma attacks than those of other ages and other residential areas.…”

Section: Discussionmentioning

confidence: 99%

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Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Sheng‐Kai

Thota

et al. 2022

Journal of Periodontology

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Background To determine whether patients who had undergone tonsillectomy would have higher risks of postoperative periodontitis. Methods Data were collected from the Taiwan Longitudinal Health Insurance Dataset from 1999 to 2013, a population‐based cohort study consisting of cases of newly‐onset sleep apnoea, chronic diseases of tonsils and adenoids, peritonsillar abscess, and periodontal diseases. A total of 1482 tonsillectomy cases and 14,796 non‐tonsillectomy controls were selected. Propensity score matching37 between the tonsillectomy group and the non‐tonsillectomy group was conducted to exclude the confounding effect resulting from indications of tonsillectomy. Cox proportional hazard model and subgroup analyses were conducted to identify subpopulations at risk of tonsillectomy‐associated periodontitis, and a sub‐outcome analysis was applied to identify the subtype of tonsillectomy‐associated periodontitis. Results A total of 648 patients who had undergone tonsillectomy and 648 out of 6509 propensity score‐matched controls were retrieved, among which 230 cases in the tonsillectomy group were associated with post‐surgical periodontitis (adjusted HR = 1.31, 95% CI = 1.08 to 1.59). The association persisted in a subpopulation of patients with periodontitis who received mechanical and surgical treatments for periodontitis (adjusted HR = 1.33, 95% CI = 1.09 to 1.63). The incidence of periodontitis was significantly high in the individuals who underwent tonsillectomy and was particularly high in those that were below 12 years of age (HR = 1.58, 95% CI = 1.10 to 2.27). The risk of periodontitis increased 4 years after tonsillectomy (HR = 1.82; 95% CI = 1.29 to 2.59). The majority of post‐tonsillectomy periodontitis was aggressive and acute periodontitis (HR = 1.37; 95% CI = 1.10 to 1.71). Conclusions Tonsillectomy performed in pediatric patients of < 12 years old, increased the risk of developing periodontitis. Aggressive and acute periodontitis as a long‐term, postoperative adverse event took place at 4 years or longer after tonsillectomy.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Sheng‐Kai

Thota

et al. 2022

Journal of Periodontology

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“…For instance, cellular therapies from donor lymphocyte infusion are utilized to treat cancer relapse following allogeneic hematopoietic stem cell transplantation to bring about graft-vs-leukemia reaction [71][72][73], where antigen-experienced T cells would recognize pathogens such as cytomegalovirus or Epstein-Barr virus. Likewise, antigen-specific T cells acquired by cell expansion or genetically engineered pathogen-specific Tc clones have been applied to infectious diseases [74,75]. In both scenarios, artificial APCs expressing ligands for T cell receptors as well as CD28 co-stimulatory molecules have been developed to prime and expand pathogen-specific effector Tc cells [76].…”

Section: Discussionmentioning

confidence: 99%

Safety and Seroconversion of Immunotherapies against SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis of Clinical Trials

et al. 2021

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Clinical trials evaluating the safety and antibody response of strategies to manipulate prophylactic and therapeutic immunity have been launched. We aim to evaluate strategies for augmentation of host immunity against severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection. We searched clinical trials registered at the National Institutes of Health by 25 May 2021 and conducted analyses on inoculated populations, involved immunological processes, source of injected components, and trial phases. We then searched PubMed, Embase, Scopus, and the Cochrane Central Register of Controlled Trials for their corresponding reports published by 25 May 2021. A bivariate, random-effects meta-analysis was used to derive the pooled estimate of seroconversion and adverse events (AEs). A total of 929,359 participants were enrolled in 389 identified trials. The working mechanisms included heterologous immunity, active immunity, passive immunity, and immunotherapy, with 62.4% of the trials on vaccines. A total of 9072 healthy adults from 27 publications for 22 clinical trials on active immunity implementing vaccination were included for meta-analyses. The pooled odds ratios (ORs) of seroconversion were 13.94, 84.86, 106.03, and 451.04 (all p < 0.01) for vaccines based on protein, RNA, viral vector, and inactivated virus, compared with that of respective placebo/control treatment or pre-vaccination sera. The pooled ORs for safety, as defined by the inverse of systemic adverse events (AEs) were 0.53 (95% CI = 0.27–1.05; p = 0.07), 0.35 (95% CI = 0.16–0.75; p = 0.007), 0.32 (95% CI = 0.19–0.55; p < 0.0001), and 1.00 (95% CI = 0.73–1.36; p = 0.98) for vaccines based on protein, RNA, viral vector, and inactivated virus, compared with that of placebo/control treatment. A paradigm shift from all four immune-augmentative interventions to active immunity implementing vaccination was observed through clinical trials. The efficacy of immune responses to neutralize SARS-CoV-2 for these vaccines was promising, although systemic AEs were still evident for RNA-based and viral vector-based vaccines.

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“…Age distribution of sicca syndrome and periodontitis among NF1 patients and NF1- controls were demonstrated, and the chi-square test was used to test the significance. The odds ratios (ORs) were derived to estimate the risk of sicca syndrome and periodontitis between the NF1 patients and NF1- controls [ 20 , 27 – 29 ]. The statistical software used was GraphPad Prism, version 5 (GraphPad Software, Inc).…”

Section: Methodsmentioning

confidence: 99%

Age-dependent oral manifestations of neurofibromatosis type 1: a case–control study

Thota

Veeravalli

Manchala

et al. 2022

Orphanet J Rare Dis

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Introduction Most craniofacial manifestations of neurofibromatosis type 1 (NF1) are considered as a result of tumor compression. We sought to determine salivary changes, caries, and periodontal complications in NF1 patients without tumors in the oral cavity. Objective and methods Eleven NF1 patients without tumors in the oral cavity and 29 matched controls without NF1 were enrolled in this case–control study. Demographic information, medical history, and data of intraoral examinations, including the Decayed, Missing, and Filled Teeth (DMFT) scores and Russel’s periodontal index (PI), were recorded. The functional salivary analysis was performed for sialometry, salivary pH values, and amylase activity. Ingenuity Systems Pathway Analysis (IPA) was conducted to identify mutually activated pathways for NF1-associated oral complications. Results NF1 patients were associated with periodontitis (OR = 1.40, 95% CI = 1.06–1.73, P = 0.04), gingivitis (OR = 1.55, 95% CI = 1.09–2.01, P = 0.0002), and decreased salivary flow rates (OR = 1.40, 95% CI = 1.05–1.76, P = 0.005). Periodontal destruction, salivary changes, and dental caries in NF1 patients were age-dependent. Subgroup analyses based on age stratification suggested that salivary flow rates and salivary amylase activities were significantly low in NF1 patients aged over 20 years and that salivary pH values, PI and DMFT scores were significantly high among NF1- controls aged over 20. All oral complications were not significantly presented in NF1 patients aged below 20 years. IPA analyses suggested that cellular mechanisms underlying NF1-associated oral complications involved chronic inflammatory pathways and fibrosis signaling pathway. Conclusion NF1 patients without tumors in the oral cavity presented a comparatively high prevalence of age-dependent oral complications, including periodontal destruction and salivary gland dysfunction, which were associated with chronic inflammatory pathogenesis.

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Correspondence to ‘Bacterial citrullinated epitopes generated byPorphyromonas gingivalisinfection—a missing link for ACPA production’

Cited by 28 publications

References 14 publications

Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Tonsillectomy as a risk factor of periodontitis: A population‐based cohort study

Safety and Seroconversion of Immunotherapies against SARS-CoV-2 Infection: A Systematic Review and Meta-Analysis of Clinical Trials

Age-dependent oral manifestations of neurofibromatosis type 1: a case–control study

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