Herbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network

Bessone, Fernando; García‐Cortés, Miren; Medina‐Cáliz, Inmaculada; Hernández, Nelia; Paraná, Raymundo; Mendizábal, Manuel; Schinoni, María Isabel; Ridruejo, Ezequiel; Nunes, Vinícius; Peralta, Mirta; Santos, Genário; Anders, Margarita; Chiodi, Daniela; Tagle, Martín; Montes, Pedro; Carrera, Enrique; Arrese, Marco; Lizarzábal, Maribel; Álvarez‐Álvarez, Ismael; Caballano-Infantes, Estefanía; Niu, Hao; Pinazo, Jose; Cabello, M.R.; Lucena, M. Isabel; Andrade, Raúl J.

doi:10.1016/j.cgh.2021.01.011

Cited by 32 publications

(31 citation statements)

References 33 publications

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“…A prospective study in Iceland purported 16% of DILI related to HDS, 2 while the US Drug-Induced Liver Injury Network reported a similar percentage (16%), with an increase from 7% from 2004 to 2005 to 20% in 2013–2014. 3 Further case–control data suggested rates of 4%–5% in studies in Latin America 4 and Germany, 5 respectively.…”

Section: Overview/commentarymentioning

confidence: 99%

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI)

Brennan

Cartlidge

Manship

et al. 2021

Frontline Gastroenterol

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Section: Overview/commentarymentioning

confidence: 99%

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI)

Brennan

Cartlidge

Manship

et al. 2021

Frontline Gastroenterol

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“…43 Recent studies from Latin America have revealed that HDS-induced DILI has increased in the past few years, with 8% of 367 DILI cases attributed to HDS. 44 In a prospective study undertaken in Iceland, HDS-induced DILI accounted for 16% of all DILI cases. 9 The widespread use of TCM and HDS is characteristic of the Asia-Pacific region.…”

Section: Liver Injury Caused By Hds/tcmmentioning

confidence: 99%

“…Data from the Spanish DILI Registry revealed that HDS was responsible for 4% (32 cases) of 856 DILI cases from 1994 to 2016 43 . Recent studies from Latin America have revealed that HDS‐induced DILI has increased in the past few years, with 8% of 367 DILI cases attributed to HDS 44 . In a prospective study undertaken in Iceland, HDS‐induced DILI accounted for 16% of all DILI cases 9 .…”

Section: Incidence Of Dili In General Populationmentioning

confidence: 99%

Incidence and risk factors of drug‐induced liver injury

Tang

Mao

2022

Liver International

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The epidemiology and aetiology of drug-induced liver injury (DILI) vary across different countries and populations. Overall, DILI is rare in the general population but has become more prevalent in hospitalized patients, especially among patients with unexplained liver conditions. In addition, drugs implicated in DILI differ between Western and Eastern countries. Antibiotics are the leading drugs implicated in DILI in the West, whereas traditional Chinese medicine is the primary cause implicated in DILI in the East. The incidence of herbal and dietary supplements-induced hepatotoxicity is increasing globally. Several genetic and nongenetic risk factors associated with DILI have been described in the literature; however, there are no confirmed risk factors for all-cause DILI. Some factors may contribute to the risk of DILI in a drug-specific manner.

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“…The proportion of AAS cases in the DILIN registry (from the USA) is 5% of the total cases [ 114 ]. In the Spanish and the Latin American DILI cohorts, the percentage of AAS-related liver damage is 2.3% and 5%, respectively [ 115 , 116 ]. Liver damage related to anabolic steroids is typically cholestatic, with marked and prolonged jaundice (usually more than 3 months).…”

Section: Anabolic Androgenic Steroids and Hccmentioning

confidence: 99%

Recreational Drugs and the Risk of Hepatocellular Carcinoma

Pinazo‐Bandera

García‐Cortés

Segovia-Zafra

et al. 2022

Cancers

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Recreational or aesthetic drug use is a distinctive behavior of humans, principally attested in the last century. It is known that recreational and illegal drugs are major contributors to the universal morbidity rate worldwide. Many of these substances have a well-established hepatotoxic potential, causing acute or chronic liver injury, liver fibrosis and cirrhosis, but their implications for hepatocellular carcinoma or other varieties of liver tumors are little known. In this article, we perform an extensive literature review, aiming to provide updated information about recreational drug use and the risk of developing liver tumors. Khat use and pyrrolizidine alkaloid consumption (present in some natural plants) have been linked to liver cirrhosis. Kava intake is associated with different liver tumors in animal models but not in humans. Cannabis’ potential to accelerate liver fibrosis in chronic hepatitis is controversial according to the existing data. Cigarette smoking is an important contributor to hepatocellular carcinoma, and anabolic androgen steroids are well-defined causes of a variety of liver cancers and other hepatic tumors. Long-term follow-up studies of subjects who have developed injuries in association with the use of recreational drugs are warranted so as to better define the risk of developing hepatocellular carcinoma in association with these substances and, thus, to implement health care policies to combat this preventable cause of cancer.

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Herbal and Dietary Supplements-Induced Liver Injury in Latin America: Experience From the LATINDILI Network

Cited by 32 publications

References 33 publications

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI)

Guideline review: EASL clinical practice guidelines: drug-induced liver injury (DILI)

Incidence and risk factors of drug‐induced liver injury

Recreational Drugs and the Risk of Hepatocellular Carcinoma

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