Photochemical fate of medetomidine in coastal and marine environments

Cai, Yi; Apell, Jennifer N.; Pflug, Nicholas C.; McNeill, Kristopher; Bollmann, Ulla E.

doi:10.1016/j.watres.2020.116791

Cited by 12 publications

(3 citation statements)

References 46 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Therefore, only analytes with high p K a values can outcompete the bidentate binding and induce enhanced chemical stimulation of the MSP leading to emission loss followed by dissociation of the polymer structure. Therefore, only in the presence of piperidine, cocaine, fentanyl, and codeine with p K a of 11.2, 8.6, 8.4, and 8.2, respectively, the system reveals higher sensitivity in comparison to weaker base analytes, such as nicotinamide, clobazam, medetomidine, and ketamine with p K a of 3.3, 4.07, 7.2, and 7.5, respectively. As can be seen, although the p K a of medetomidine and ketamine is higher than the p K a of phenanthroline (p K a 4.86), the double binding capacity of phenanthroline prevents its substitution by medetomidine or ketamine.…”

Section: Resultsmentioning

confidence: 99%

Stimuli Response of Eu³⁺-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

et al. 2023

View full text Add to dashboard Cite

Metallo-supramolecular polymers offer a highly controllable platform for sensing. Their modular characteristics obtained by the ability of varying both building blocks, the metal ion and the organic ligand, provide tunability of their optical and chemical properties. Specifically, polymers based on lanthanide ions and conjugated aromatic ligands exhibit enhanced luminescence properties that can be altered by external stimulation. Herein, using europium-based polymers, we demonstrate the ability to detect different pharmaceutical amines, including in complex biological media, based on their luminescence quenching efficiency as a result of their polymer dissociation capacity. A combination of absorption, luminescence, and NMR measurements reveals combined static and dynamic quenching mechanisms that enable selective sensing of strong basic amines with high pK a values.

show abstract

Section: Resultsmentioning

confidence: 99%

Stimuli Response of Eu³⁺-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

et al. 2023

View full text Add to dashboard Cite

show abstract

“…At each time point, we collected aliquots for UPLC (150 μL) and MS (800 μL) analyses. To quantify [OH • ] ss , we used the same setup (with 6 lamps), but experimental solutions contained benzoate (BA; 10 μM or 1 mM) in addition to the model compound. , Unlike experiments for CO quantification, the borosilicate test tubes were left uncapped.…”

Section: Methodsmentioning

confidence: 99%

Photochemical Production of Carbon Monoxide from Dissolved Organic Matter: Role of Lignin Methoxyarene Functional Groups

Ossola

Gruseck

Houska

et al. 2022

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Carbon monoxide (CO) is the second most abundant identified product of dissolved organic matter (DOM) photodegradation after CO 2 , but its formation mechanism remains unknown. Previous work showed that aqueous photodegradation of methoxy-substituted aromatics (ArOCH 3 ) produces CO considerably more efficiently than aromatic carbonyls. Following on this precedent, we propose that the methoxy aromatic groups of lignin act as the C source for the photochemical formation of CO from terrestrial DOM via a two-step pathway: formal hydrolytic demethylation to methanol and methanol oxidation to CO. To test the reasonableness of this mechanism, we investigated the photochemistry of eight lignin model compounds. We first observed that initial CO production rates are positively correlated with initial substrate degradation rates only for models containing at least one ArOCH 3 group, regardless of other structural features. We then confirmed that all ArOCH 3 -containing substrates undergo formal hydrolytic demethylation by detecting methanol and the corresponding phenolic transformation products. Finally, we showed that hydroxyl radicals, likely oxidants to initiate methanol oxidation to CO, form during irradiation of all models. This work proposes an explicit mechanism linking ubiquitous, abundant, and easily quantifiable DOM functionalities to CO photoproduction. Our results further hint that methanol may be an abundant (yet overlooked) DOM photoproduct and a likely precursor of formaldehyde, formic acid, and CO 2 and that lignin photodegradation may represent a source of hydroxyl radicals.

show abstract

“…Having reliable estimates of irradiance values is important for accurate predictions of the rates of photochemical processes. For example, since photochemical transformation can be an important removal process for some organic contaminants in environmental systems, − accurate irradiance values are needed to properly predict photochemical rates. Using a laboratory light source to approximate environmental solar irradiance often represents a best-case scenario of summer noon (or even more intense) sunlight ,, and can be non-representative of realistic environmental conditions over the course of a year.…”

Section: Introductionmentioning

confidence: 99%

Global Corrections to Reference Irradiance Spectra for Non-Clear-Sky Conditions

Partanen

McNeill

2023

Environ. Sci. Technol.

Self Cite

View full text Add to dashboard Cite

Photochemical reactions in surface waters play important roles in element cycling and in the removal of organic contaminants, among other processes. A central environmental variable affecting photochemical processes in surface waters is the incoming solar irradiance, as this initiates these processes. However, clear-sky incident irradiance spectra are often used when evaluating the fate of aquatic contaminants, leading to an overestimation of contaminant decay rates due to photochemical transformation. In this work, incident irradiance satellite data were used to develop global-scale non-clear-sky correction factors for commonly used reference irradiance spectra. Non-clear-sky conditions can decrease incident irradiance by over 90% depending on the geographic location and time of the year, with latitudes above 40°N being most heavily affected by seasons. The impact of non-clear-sky conditions on contaminant half-lives was illustrated in a case study of triclosan in lake Greifensee, which showed a 39% increase in the triclosan half-life over the course of a year under non-clear-sky conditions. A global annual average correction factor of 0.76 was determined as an approximate way to account for non-clear-sky conditions. The correction factors are developed at monthly and seasonal resolutions for every location on the globe between 70°N and 60°S at a 4 km spatial resolution and can be used by researchers, practitioners, and regulators who need improved estimates of incident irradiance.

show abstract

Photochemical fate of medetomidine in coastal and marine environments

Cited by 12 publications

References 46 publications

Stimuli Response of Eu³⁺-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

Stimuli Response of Eu³⁺-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

Photochemical Production of Carbon Monoxide from Dissolved Organic Matter: Role of Lignin Methoxyarene Functional Groups

Global Corrections to Reference Irradiance Spectra for Non-Clear-Sky Conditions

Contact Info

Product

Resources

About

Photochemical fate of medetomidine in coastal and marine environments

Cited by 12 publications

References 46 publications

Stimuli Response of Eu3+-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

Stimuli Response of Eu3+-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

Photochemical Production of Carbon Monoxide from Dissolved Organic Matter: Role of Lignin Methoxyarene Functional Groups

Global Corrections to Reference Irradiance Spectra for Non-Clear-Sky Conditions

Contact Info

Product

Resources

About

Stimuli Response of Eu³⁺-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines

Stimuli Response of Eu³⁺-Based Metallo-Supramolecular Polymers toward Pharmaceutical Amines