Influence of <i>AMY1A</i> copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence

Hariharan, Rohit; Mousa, Aya; Courten, Barbora de

doi:10.1111/obr.13205

Cited by 3 publications

(3 citation statements)

References 58 publications

(233 reference statements)

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“…Amylase is secreted as salivary amylase and pancreatic amylase, of which serum amylase levels reflect both forms in roughly equal parts 81 . Regarding salivary amylase in obesity, differences in gene copy number, which may influence enzyme levels, have been the topic of ample research, but fall outside the scope of this review 82,83 . Regarding serum amylase, several studies have examined fasting levels and observed lower amylase levels with increasing adiposity 84–87 .…”

Section: Effect Of Obesity On Gastrointestinal Enzyme Secretion and S...mentioning

confidence: 99%

“…81 Regarding salivary amylase in obesity, differences in gene copy number, which may influence enzyme levels, have been the topic of ample research, but fall outside the scope of this review. 82,83 Regarding serum amylase, several studies have examined fasting levels and observed lower amylase levels with increasing adiposity. [84][85][86][87] However, these results should be interpreted with caution as they could reflect changes in both pancreatic and salivary secretions.…”

Section: Pancreatic Amylasementioning

confidence: 99%

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Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion

Steenackers,

Eksteen,

Wauters

et al. 2024

Neurogastroenterology Motil

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Background and PurposeThe pathophysiology of obesity has been the product of extensive research, revealing multiple interconnected mechanisms contributing to body weight regulation. The regulation of energy balance involves an intricate network, including the gut–neuroendocrine interplay. As a consequence, research on the gut–brain–microbiota axis in obesity has grown extensively. The physiology of the gastrointestinal tract, far from being underexplored, has significant implications for the development of specific complications in people living with obesity across the fields of gastroenterology, nutrition, and pharmacology. Clinical research indicates higher fasting bile acids serum levels, and blunted postprandial increases in bilious secretions in people living with obesity. Findings are less straightforward for the impact of obesity on gastric emptying with various studies reporting accelerated, normal, or delayed gastric emptying rates. Conversely, the effect of obesity on gastrointestinal pH, gastrointestinal transit, and gastric and pancreatic enzyme secretion is largely unknown. In this review, we explore the current evidence on the gastrointestinal physiology of obesity.

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Section: Effect Of Obesity On Gastrointestinal Enzyme Secretion and S...mentioning

confidence: 99%

Section: Pancreatic Amylasementioning

confidence: 99%

Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion

Steenackers,

Eksteen,

Wauters

et al. 2024

Neurogastroenterology Motil

View full text Add to dashboard Cite

show abstract

“…3a). Moreover, the selected metabolic gene set included ATP energy metabolism genes 22 (ATP2A1, ATP2C2, ATP6V0D1) located on chromosome 16, carbohydrate metabolism genes 23 (AMY1A, AMY1B, AMY1C) on chromosome 1, as well as detoxi cation and drug metabolism genes 24 (GSTM1, GSTM2, GSTM3) together (Supplementary Fig. 3b).…”

Section: Genes Functional Characteristics Of Complex Regionsmentioning

confidence: 99%

Deciphering Complex Regions within the Human Genome and Unraveling Their Critical Biomedical Regulatory Functions

Du,

Li,

Zhu

et al. 2024

Preprint

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Background: Nuclear genomic DNA plays a crucial role in individual development and phenotype determination. The genetic landscape within populations exhibits significant heterogeneity, contributing to diverse human traits. Current studies of human genome heterogeneity often focus on specific segments of high-frequency phenotype-associated sequences or structurally complex regions. Therefore, to overcome the limitations of previous studies and more directly explore population heterogeneity, it is essential to study the entire genome rather than focusing only on known phenotype-associated regions. Results: Using set theory, we have clearly defined Complex Regions (Complex_Region) by integrating pan-genome datasets, covering about 8.1% of the human genome. These regions exhibit high sequence diversity and nonrandom long continuous fragments (≥450kb), thus reflecting population genetic complexity. Our enrichment analysis revealed that genes within Complex_Region are primarily involved in immunity and metabolism, indicating chromosome-specific functional enrichment. Notably, immune genes are mainly located on chromosomes 6 and 19, which are closely associated with disease occurrence. Moreover, these regions are enriched for human phenotype-related signals and tumor somatic mutations, providing novel insights for large-scale cohort studies. We also detected ancient viral sequences, particularly ~9.47 kb human endogenous retroviruses (HERV) insertion sequence NC_022518, which is diverse in humans but remains conserved across primates, to be implicated in regulating bodily functions and various diseases. Conclusions: Our study highlights the biomedical importance of Complex_Region by revealing associations among genotypes, environment, and phenotypes. This enhances our understanding of life regulation and phenotype shaping, highlighting the role of these regions in immunity, metabolism, and disease association.

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We Are What, When, And How We Eat: The Evolutionary Impact of Dietary Shifts on Physical and Cognitive Development, Health, and Disease

Bragazzi,

Del Rio,

Mayer

et al. 2024

Advances in Nutrition

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Influence of AMY1A copy number variations on obesity and other cardiometabolic risk factors: A review of the evidence

Cited by 3 publications

References 58 publications

Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion

Understanding the gastrointestinal tract in obesity: From gut motility patterns to enzyme secretion

Deciphering Complex Regions within the Human Genome and Unraveling Their Critical Biomedical Regulatory Functions

We Are What, When, And How We Eat: The Evolutionary Impact of Dietary Shifts on Physical and Cognitive Development, Health, and Disease

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