Functional characterization of nociceptive mechanisms involved in fibromyalgia and electroacupuncture

Lottering, Bernice; Lin, Yi‐Wen

doi:10.1016/j.brainres.2020.147260

Cited by 6 publications

(10 citation statements)

References 72 publications

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“…ese data suggest that EA might directly inhibit TRPV1 on neuronal membranes and its downstream pathways [18]. e transmission of pain sensations is mediated mainly by the amygdala, thalamus, PFC, and somatosensory cortex in the mouse brain.…”

Section: Discussionmentioning

confidence: 92%

“…A recent article showed that the symptoms of fibromyalgia-like pain induced by ICS were improved when the TRPV1 gene was deleted ( Trpv1 −/− ). These data suggest that EA might directly inhibit TRPV1 on neuronal membranes and its downstream pathways [ 18 ]. The transmission of pain sensations is mediated mainly by the amygdala, thalamus, PFC, and somatosensory cortex in the mouse brain.…”

Section: Discussionmentioning

confidence: 99%

“…We demonstrated that inflammatory mediators can modulate the TRPV1 signalling pathway for managing fibromyalgia pain. We also implicated TRPV1 and related components in responses to fibromyalgia-like pain in the ICS model in the prefrontal cortex, somatosensory cortex, hippocampus, and thalamus of the brain [ 18 ]. We also demonstrated that TRPV1 proteins and related molecules were meaningfully reduced in the mice mPFC, hippocampus, and PAG.…”

Section: Discussionmentioning

confidence: 99%

“…The current study aimed to examine the effect of EA on cold stress-induced fibromyalgia pain in mice. Our previous work showed that EA attenuates complete Freund's adjuvant (CFA)-induced local inflammatory pain [ 17 ] and intermittent cold stress (ICS)-induced widespread pain [ 18 ]. We hypothesized that mutual regulation of the HMGB1/S100B and RAGE/TLR2/TLR4 axes and TRPV1 occurred but the mechanisms remain unclear.…”

Section: Introductionmentioning

confidence: 99%

“…What the actual evidence-based mechanisms of EA are remains a mystery. e ST36 acupoint is commonly used in traditional Chinese medicine for the treatment of various pathological conditions, most notably pain [17][18][19][20]. EA has been shown to reduce inflammatory [17,19], neuropathic [21], and fibromyalgia [18] pain in mice by promoting the release of endogenous opiates, dopamine, and adenosine.…”

Section: Introductionmentioning

confidence: 99%

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Electroacupuncture Reduces Fibromyalgia Pain by Attenuating the HMGB1, S100B, and TRPV1 Signalling Pathways in the Mouse Brain

Hsiao

Lin

2022

Evidence-Based Complementary and Alternative Medicine

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Fibromyalgia is characterized by chronic and persistent widespread pain and generalized muscle tenderness, and it is refractory to treatment. The central nervous system (CNS) plays an important role, pain signalling, in fibromyalgia subjects. Electroacupuncture (EA) has been practiced for thousand years to treat many diseases that involve pain. We established fibromyalgia-like pain in mice using intermittent cold stress and investigated therapeutic effects and modes of action with EA. EA of 2 Hz and 1 mA was performed for 20 min at the ST36 acupoint in mice from Day 3 to Day 5. Our results showed that mechanical and thermal hyperalgesia were induced by intermittent cold stress (Day 5: mechanical: 1.43 ± 0.34 g; thermal: 3.98 ± 0.73 s) and were subsequently reversed by EA (Day 5: mechanical: 4.62 ± 0.48 g; thermal: 7.68 ± 0.68 s) or Trpv1−/− (Day 5: mechanical: 4.38 ± 0.51 g; thermal: 7.48 ± 0.98 s). Activity in the HMGB1, S100B, and TRPV1 pathways was increased in the mouse prefrontal cortex, somatosensory cortex, thalamus, and amygdala with the stress treatment. This increase was attenuated by EA or Trpv1−/−. These results suggest potential targets for the treatment of TRPV1-dependant fibromyalgia pain.

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Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%